2025 NFL Week 18 Best Bets - Football Lines

2025 NFL Week 18 Best Bets - Football Lines

The NFL playoffs don’t officially begin until January 10 with the Wild Card round. However, four teams are in playoff-mode entering the final week of the regular season. One division in each conference has a winner-take-all matchup in Week 18 at which point the postseason field will be complete. Playing without two-time MVP Lamar Jackson, the Baltimore Ravens kept their hopes alive with a win over the Packers on Sunday behind Derrick Henry’s 216-yard, four-touchdown rushing performance.

The Steelers could have clinched the division on Sunday but they were upset by the Browns, 13-6, setting the stage for this showdown between bitter rivals. The teams met in Week 14 with Pittsburgh pulling off a 27-22 upset as a 6-point road underdog. According to John Harbaugh the status of Jackson is “to be determined” later in the week. The Steelers missed leading receiver D.K. Metcalf and failed to score a touchdown in Cleveland. Pittsburgh won the last two meetings at home over the Ravens but hit the board as a 3.5-point dog.

There’s a similar situation in the NFC South with the Carolina Panthers and Tampa Bay Buccaneers starting the betting week for the division crown. Even though they’ve lost four in a row and seven of their last eight games, the Bucs can clinch the title and No. 4 seed with a win. The teams played just two weeks ago with Carolina getting two TD passes from Bryce Young and a late field goal for a 23-20 victory. The Panthers were a 3-point home dog in that game and they’re nearly the same for Saturday’s contest opening +2.5 in most NFL betting markets.

NFL Betting Lines

2025 NFL Week 18 Betting Lines

*Odds as of Tuesday, December 30, 1:00 PM ET

We know the teams that will be in the playoffs but we don’t know where they’ll be seeded. The NFC West winner and No. 1 seed in the conference will be determined on Saturday night in Santa Clara when the 49ers host Seattle. Both teams are on fire heading into the matchup. The Seahawks beat Carolina 27-10 last week, their sixth consecutive win 10th in 11 games. During that stretch Seattle is 8-3 against the spread.

The Niners stretched their winning streak to six games by beating Chicago 42-38 on Sunday night. The streak began with the return of Brock Purdy to the lineup. Purdy threw three TD passes and ran for a pair of scores against the Bears. During the streak the Niners are averaging nearly 36 points and they cashed the OVER in their last three games.

The teams played in the season opener back in September with SF earning a hard fought 17-13 victory. Seattle boasts one of the top defenses in the NFL giving up the second fewest points per game and yards per play. They also have a potent offense led by Sam Darnold. Seattle is second in scoring averaging 29.4 points with Darnold chucking 25 TD passes. San Francisco has won seven of the last eight meetings getting six payouts in that span.

The No. 1 seed in the AFC will be determined with the Broncos having the inside track. Denver wins a tie-breaker with New England and only needs to take care of the Chargers on Sunday to get Wild Card Weekend off. Denver didn’t face Patrick Mahomes in last week’s win over Kansas City and it was announced Justin Herbert will not play for the Bolts on Sunday. As a result the Broncos are listed as a 12.5-point favorite on the early line.

Jacksonville clinched just its second playoff berth in eight seasons and can wrap up the AFC South with a home win over Tennessee in the finale as a 12.5-point favorite. They can also forge a three-way tie at the top of the conference if both Denver and New England lose. That’s a tall task considering the competition. The Pats are an 11-point home favorite against the Dolphins and Denver is a heavy fave against the watered-down Chargers.

Those are three of the four double-digit favorites on the early Week 18 betting line. The other is also in the AFC with the Houston Texans laying 10-points for their home game with Indianapolis. The fall was hard for the Colts, who at one point led the AFC with a 7-1 record. Injuries derailed the season and bring Philip Rivers out of retirement didn’t stop the bleeding.

NFL Schedule

• Week 1
• Week 2
• Week 3
• Week 4
• Week 5
• Week 6
• Week 7
• Week 8
• Week 9
• Week 10
• Week 11
• Week 12
• Week 13
• Week 14
• Week 15
• Week 16
• Week 17
• Week 18

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