NFL Week 5 Betting Online
Week 5 of the 2025 NFL season opens with a Thursday night Prime Video matchup of the San Francisco 49ers at the Los Angeles Rams. Decades ago, this was one of the better rivalries in the NFL, and there have been some important matchups between these teams in recent years. The most important game in the current era was the 2021 NFC championship game, which the Rams came from behind to win 20-17 en route to their Super Bowl championship. The 49ers are coming off a lost season due to a massive injury list headed by Christian McCaffrey. The Rams made the 2024 NFC playoffs but were not a credible Super Bowl contender. Still, they remain playoff caliber for 2025.
NFL Betting Lines
2025 NFL Week 5 Schedule
TEAMS ON BYE: Falcons, Bears, Packers & Steelers
Tottenham Hotspur Stadium is best known as the home of the famed English Premier League soccer club. But on Sunday morning, October 5, it will host a National Football League game between the Minnesota Vikings and the Cleveland Browns, not to mention a potential circus.
Shedeur Sanders was drafted much later than most experts expected, but he finally landed with the Cleveland Browns, who have a seriously questionable quarterback room. Sanders is getting all of the media’s love, and that will only grow as training camp progresses.
The quarterback depth chart is unsettled, with Joe Flacco, Kenny Pickett, Dillon Gabriel, and Sanders all listed. Last year’s starter, DeShaun Watson, is trying to battle back from injury and likely will miss most, if not all, of the season. Thus, there is enough of a window to cause a media and X.com firestorm demanding Sanders be the man under center. The bigger question is whether Sanders can actually play effectively as an NFL QB.
Minnesota will start 2024 first-round draft pick JJ McCarthy at QB. Sam Darnold was sent packing after a 14-3 season in which the Vikings tried to trade him despite that success. McCarthy led the Michigan Wolverines to the 2023 national championship, but not everyone is sold on his physical ability.
In the late afternoon window, the Detroit Lions will visit the Cincinnati Bengals in a key interconference matchup that could also be a Super Bowl preview. Detroit believes it would have made the Super Bowl last year if not for an injury to DE Aidan Hutchinson. Cincinnati also believes they were Super Bowl material if not for QB Joe Burrow missing most of the campaign.
NBC Sunday Night Football offers an AFC East matchup of the New England Patriots against the Buffalo Bills. New England’s one-year Jerod Mayo experiment was ended after a brutal 4-13 record, but it must be admitted that Bill Belichick left an empty cupboard and a demoralized franchise. Mike Vrabel has come home to New England, where he was a former player. Vrable is best known for his success as head coach of the Tennessee Titans, where he went 54-45 in six seasons with three playoff appearances. Vrabel will bring a sense of order, physicality, and fundamental football that is essential for success.
Drake Maye has plenty of on-the-job training after a solid rookie campaign on a terrible New England team that was poorly led. There is faith that Vrabel can build a coherent offense and team around Maye, who was picked third overall in the 2024 NFL Draft.
Regardless of Vrabel and New England’s potential, a Sunday night game at the Buffalo Bills will be a tall order.
NFL Schedule
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