2025 NFL Week 10 Online Betting - Football Picks

2025 NFL Week 10 Best Bets - Football Lines

Week 10 of the NFL season opens with a classic AFC West rivalry matchup on Thursday Night Football and closes with a battle between NFC contenders on Monday Night Football. In between 12 games will be played with five of them between division partners. The biggest one could be a Golden State matchup between the Rams and 49ers. LA enters the week tied with Seattle for first in the NFC West with the SF having the same number of wins but one more loss. The Niners beat The Rams earlier in the season and they are 3-0 against division foes. Seattle plays host to Arizona in the other NFC West matchup.

A total of 14 games are on the slate with the Bengals, Cowboys, Titans and Chiefs taking their bye. It’s probably a good thing since all four teams lost in Week 9. KC had won three in a row and five of six before falling to Buffalo, 28-21, on Sunday. It was huge for the Bills, who finally beat a team with a winning record. Buffalo heads to Miami this week as the biggest favorite on the early Week 10 board laying 10 points. The Bills are 0-2 ATS when playing as a double-digit favorite.

Riding a 6-game winning streak the Denver Broncos are tied with Indianapolis and New England for the best record in the NFL at 7-2. The Broncos used another fourth quarter comeback to beat Houston, 18-15, on Sunday, their fourth win by four points or less and also their fourth win when trailing entering the final frame. They opened as a 9-point favorite in their AFC West matchup with Las Vegas. The Raiders have lost two in a row and six of seven going 1-5-1 ATS in that span.

NFL Betting Lines

2025 NFL Week 10 Betting Lines

TEAMS ON BYE: Bengals, Cowboys, Chiefs & Titans

*Odds as of Tuesday, November 4, 11:00 AM ET

Last week was a good one for underdogs, who got the cash in nine of the 14 games played with six teams winning outright. The biggest was Carolina beating Green Bay, 16-13, as a 13.5-point dog. Minnesota was +9.5 and stunned Detroit, 27-24, on the road. For just the second time this season the Panthers are favored laying 6-points to the Saints. They were -1 in Week 7 and beat the Jets 13-6. The Panthers are 5-4 SU and 6-3 ATS just one win behind Tampa Bay in the NFC South.

Washington surprised a lot of folks last year with their playoff run and win over top-seed Detroit in the Divisional Round. Things haven’t gone according to plan with Sunday’s 38-14 loss to Seattle the Commanders fourth straight. And more concerning is the health of Jayden Daniels. Last season’s Offensive Rookie of the Year exited the game in the fourth quarter with an injury and is expected to be out for a considerable length of time. The Lions are also coming off a loss and haven’t dropped two in a row since the middle of the 2022 season. Detroit is laying 9.5-points, the second highest spread on the early Week 10 board.

The Colts got a taste of reality last week suffering their second loss of the season. Not many had Indy entering Week 9 with the best record in the NFL, but there they were with a glossy 7-1 mark. The jury is still out on whether they are a legitimate contender and if Daniel Jones is the guy that can lead them to the Promised Land. Jones had five of the team’s six turnovers and the Colts matched a season low point total in the 27-20 loss. The Colts look to rebound as a 6-point home favorite against the Falcons, who have lost three in a row.

A matchup between AFC contenders takes place on Sunday night when the Chargers host the Steelers as an early 3-point favorite. LA escaped with a 27-20 win as a 10-point favorite over Tennessee on Sunday but failed to cover the spread for the fifth time in six games. Pittsburgh ended a 2-game slide by upsetting the Colts at home.

The betting week closes with a battle between NFC contenders Philadelphia and Green Bay on Monday night. The Packers were humbled at home by Carolina, 16-13, as a big 13.5-point favorite and also lost earlier in the year as a 7.5-point favorite to Cleveland. The Packers may have been looking ahead to this matchup against the team that beat them to open and close last season.

NFL Schedule

• Week 1
• Week 2
• Week 3
• Week 4
• Week 5
• Week 6
• Week 7
• Week 8
• Week 9
• Week 10
• Week 11
• Week 12
• Week 13
• Week 14
• Week 15
• Week 16
• Week 17
• Week 18

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With the Cash Out feature you can choose to eliminate a wager that's already been placed, and receive back either a portion, or your full stake amount.

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