2025 NFL Week 16 Best Bets - Football Lines

2025 NFL Week 16 Best Bets - Football Lines

With the college football regular season concluded the NFL will take over on Saturday starting in Week 16 with a pair of divisional matchups. Prior to that, however, one of the biggest games of the season gets the week started with a showdown between the two best team in the NFC on Thursday Night Football. The Rams and Seahawks enter the contest with identical 11-3 records, a game behind Denver for the NFL’s top mark and a game ahead of San Francisco in the NFC West. LA won the earlier meeting 21-19 in Week 11 and has won eight of nine. And that was Seattle’s only setback in its last nine games. The Seahawks opened as a slight 1.5-point home favorite.

Two weeks ago the Packers took over first place in the NFC North with a 28-21 win over Chicago. Green Bay gave the lead back and suffered a bigger loss with defensive standout Micah Parsons sustaining a knee injury last week in Denver. The two meet again in the late game on Saturday following the NFC East confrontation between the Eagles and Commanders. Philly stopped a 3-game slide with a 31-0 thrashing of Las Vegas on Sunday and can clinch the division with a win.

The NFL took advantage of its flex scheduling to change the Sunday Night Football contest moving the Patriots at Ravens game into the primetime slot. The Patriots had their 10-game winning streak come to an end and their lead in the AFC East shrink with a loss to Buffalo. The Pats allowed 28 points in a second half collapse, that’s more points than they surrendered in any game this season. The Ravens shutout Cincinnati on Sunday for their sixth win in eight games and they are a game behind Pittsburgh in the AFC North. Baltimore opened as a 3-point home favorite.

NFL Betting Lines

2025 NFL Week 16 Betting Lines

*Odds as of Tuesday, December 16, 12:00 PM ET

Injuries will play a role in the playoff races and impact the Week 16 betting lines. Parsons has been a force for the Green Bay defense with 12.5 sacks and two FFs for the NFL’s sixth best total defense and eighth best scoring defense. The early line had the Packers as high as -3 but the number has since settled to -1.

The Kansas City Chiefs had their decade-long playoff run and three-straight AFC championships laid to rest with a loss to the Chargers on Sunday that officially eliminated them. A bigger loss was Patrick Mahomes suffering a knee injury costing him the remainder of the season. Gardner Minshew will start when the Chiefs take on Tennessee. The line opened with KC laying 10 points but has dropped to KC -3 as of Tuesday.

The way things have gone the last few weeks the Saints should probably be declared winners of the NFC South. New Orleans upset division co-leaders Tampa Bay and Carolina the last two weeks setting up a battle for the outright lead between the Bucs and Panthers Sunday in Charlotte. Tampa has dropped two straight and five of six but opened as a 3-point road favorite.

There are several other games to keep an eye on Sunday, including a matchup of division leaders in the AFC with Jacksonville visiting Denver. The Broncos put their 11-game winning streak on the line as a 3-point favorite. Winners of five straight the Jags have a 1-game lead over Houston in the South. Aaron Rodgers will attempt to haunt the Detroit Lions once again only this time as a member of the Steelers. Detroit hasn’t lost consecutive games since the middle of the 2022 season but alternating wins and losses isn’t going to get them in the postseason. They need wins and are favored by 7-points in this interconference tilt.

Needing a QB after injuries to Daniel Jones and Riley Leonard, the Colts brought Philip Rivers out of retirement to try and turn the season around. Indy has lost four straight falling out of the playoff race in the AFC. Rivers gets a chance in primetime to show he can still play in a matchup with the San Francisco 49ers on Monday Night Football.

NFL Schedule

• Week 1
• Week 2
• Week 3
• Week 4
• Week 5
• Week 6
• Week 7
• Week 8
• Week 9
• Week 10
• Week 11
• Week 12
• Week 13
• Week 14
• Week 15
• Week 16
• Week 17
• Week 18

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