2025 NFL Week 2 Online Betting - Football Picks

NFL Week 2 Betting Online

NFL Week 2 Betting Odds

Week two opens with the 2025 Amazon Prime Video opener and a potential playoff matchup between the Green Bay Packers and the Washington Commanders. Last year, the Commanders were what the Packers were in 2023. Washington came out of nowhere to make the playoffs and ended up in the NFC championship game. Rookie QB Jayden Daniels demonstrated why he should have been the first overall pick of the 2024 NFL Draft with a sensational season. Meanwhile, Green Bay took a step back, losing in the NFC wild card round, following an appearance in the 2023 NFC divisional playoffs. Now the question is if it is Washington who will take a step back, and if the Pack will be back. With Jordan Love calling signals for the Packers, the quarterback matchup is top shelf. Amazon Prime is getting its money’s worth.

NFL Betting Lines

2025 NFL Week 2 Schedule

MATCHUP TIME (ET) TV
Thursday, September 11
Commanders at Packers 8:15 PM Prime Video
Sunday, September 14
Browns at Ravens 1:00 PM CBS
Jaguars at Bengals 1:00 PM CBS
Giants at Cowboys 1:00 PM FOX
Bears at Lions 1:00 PM FOX
Patriots at Dolphins 1:00 PM CBS
49ers at Saints 1:00 PM FOX
Bills at Jets 1:00 PM CBS
Seahawks at Steelers 1:00 PM FOX
Rams at Titans 1:00 PM CBS
Panthers at Cardinals 4:05 PM CBS
Broncos at Colts 4:05 PM CBS
Eagles at Chiefs 4:25 PM FOX
Falcons at Vikings 8:20 PM NBC
Monday, September 15
Buccaneers at Texans 7:00 PM ABC
Chargers at Raiders 10:00 PM ESPN
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In the early Sunday window, there are quite a few games worthy of attention. Certainly, among the top matchups is the Buffalo Bills at the New York Jets. Aaron Glenn is the new head coach of the Jets, with Justin Fields number one on the QB depth chart entering training camp. Fields was the 11th overall pick of the 2021 NFL Draft by the Chicago Bears, who gave up on him after three years. Now Fields has a new lease on life with Russell Wilson off to the New York Giants. Glenn will have to make the Fields situation work as the backups are Tyrod Taylor, Adrian Martinez, and Brady Cook. As for the Bills, they bring a veteran team that is expected to be knocking on the Super Bowl door again.

In the late Sunday afternoon window, the Kansas City Chiefs will host the Philadelphia Eagles in a rematch of last season’s Super Bowl, which the Eagles won in a blowout. The Chiefs have vowed to rededicate themselves to redeeming themselves with a Super Bowl championship after blowing the chance for an unprecedented third consecutive Lombardi Trophy in humiliating fashion. Certainly, the Chiefs will have a raucous Arrowhead crowd on their side that is out for blood. Gambling action figures to be heavy on the Chiefs, thus leaving potential value on the Eagles.

Monday night offers a doubleheader, with the Tampa Bay Buccaneers visiting the Houston Texans in the first matchup. Both teams are coming off playoff seasons and are expected to contend for the postseason again in 2025. CJ Stroud has proven to be the answer as the Houston quarterback, with two playoff seasons in two years. Meanwhile, Baker Mayfield has resurrected his career with the Buccaneers.

Following that is an AFC West showdown between old foes. Jim Harbaugh will take his Los Angeles Chargers to Sin City to take on Pete Carroll and his Las Vegas Raiders. Harbaugh and Carroll used to go at it in the college ranks, with Harbaugh leading Stanford and Carroll at USC. Later, Harbaugh led the San Francisco 49ers against Carroll’s Seattle Seahawks. Most of the games were steel cage matches for high stakes. Carroll was the surprise hire of the Raiders after taking a year off in 2024. Harbaugh clearly has the Chargers on the ascent. Geno Smith, who was Carroll’s QB at the end of his tenure with Seattle, is now under center for the Raiders. The Chargers will have an advantage with Justin Herbert under center.

NFL Schedule

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