Los Angeles Chargers Week 1 Best Bets - NFL Betting Lines

Los Angeles Chargers Week 1 Best Bets - NFL Betting Lines

The Los Angeles Chargers enter the 2025 NFL betting season looking to close the gap in the AFC West under second-year head coach Jim Harbaugh. Sportsbooks have given the Bolts respectable futures positioning: the Chargers are priced at +2404 Super Bowl odds, +1203 to win the AFC Championship, and +336 to win the division. Their NFL win total is set at 8.5 games, a middle-of-the-pack figure that suggests competitiveness but not contender status just yet. Chargers fans can now bet the NFL with Bitcoin at BookMaker Sportsbook, featuring fast crypto deposits and withdrawals.

Quarterback Justin Herbert remains the centerpiece of Los Angeles’ NFL betting outlook, but the offense has been reshaped with additions like Najee Harris and rookie Omarion Hampton in the backfield and continued development of young receivers. Harbaugh’s culture shift has been felt, but consistency is the hurdle the Chargers must overcome if they’re to outperform their expected NFL futures odds.

Chiefs vs. Chargers Week 1 Betting Lines

Spread: Chiefs -3

Total: 45

Money Line: Chiefs -165, Chargers +144

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Los Angeles Chargers Week 1 Matchup

On Friday, September 5, 2025, the Los Angeles Chargers will square off with the Kansas City Chiefs at Corinthians Arena in São Paulo, Brazil. Kickoff is set for 8:00 p.m. ET with exclusive coverage on YouTube. NFL point spreads opened with Los Angeles as +2.5 underdogs, and early money pushed the spread up to +3 at reduced juice. The NFL total opened at 44 and ticked up to 45, showing bettors expect a higher-scoring affair despite both teams’ recent head-to-head tendency toward playing to low scorers.

For the Chargers, the storyline is about ending a losing streak. Los Angeles has dropped seven straight games to Kansas City, though they’ve remained competitive on the NFL spread. The Chargers are 2–8 straight up but 6–3–1 against the spread in their last ten meetings with the Chiefs, a sign that while they rarely win outright, they often stay within the number. Four of the last five meetings have cashed Unders, a trend totals bettors will factor into NFL Week 1 betting picks.

Injuries cloud the picture. Quentin Johnston and Najee Harris are questionable for Week 1, while lineman Mekhi Becton is also uncertain. Left tackle Rashawn Slater is also on injured reserve, a significant blow to Herbert’s protection and the front wall opening running lanes. Bettors will weigh these injuries heavily when deciding whether Los Angeles can cover the NFL spread against Mahomes and the defending AFC West champions.

Trends provide mixed signals. The Chargers are 6–4 straight up and 7–3 ATS in their last ten road games, but their struggles against Kansas City straight up are glaring. Still, NFL betting lines show respect for the Chargers’ ability to keep games close, especially in divisional matchups. Bettors who believe in Herbert’s talent may see value in Los Angeles as short neutral field underdogs.

Los Angeles Chargers 2024-25 Recap

The Chargers’ 2024 season was another exercise in frustration. They finished 11–6 straight up, 12–5 against the spread, and 8–9 to the Over/Under, a profile that rewarded NFL spread bettors but left totals backers in flux. For those making NFL picks, Los Angeles was one of the league’s better ATS teams, consistently covering numbers even when they fell short in marquee games.

Several players broke out in 2024. Wide receiver Ladd McConkey flashed throughout his first go round at the pro level, positioning himself as a potential breakout star heading into 2025. On defense, pass rusher Tuli Tuipulotu stepped forward as a disruptive force, complementing Khalil Mack and giving Los Angeles a dangerous front seven. These bust-out performances provided hope that the Chargers’ young core is ready to carry more of the load.

Herbert, as always, was the steadying presence. His ability to keep the offense competitive even behind an inconsistent offensive line made Los Angeles a reliable bet against the number. However, the lack of playoff success and continued failure to beat Kansas City has kept them from rising higher on NFL futures boards.

From a betting standpoint, Los Angeles was a strong play for NFL spread picks, but totals bettors found less stability. Their 8–9 O/U record reflected uneven game flow, with some shootouts but just as many defensive battles. Bettors targeting Overs or Unders had to pick their spots carefully, while spread bettors found Los Angeles one of the league’s most profitable teams in 2024.

Looking ahead, the 8.5-win total set by sportsbooks reflects cautious optimism. The Chargers are good enough to stay in the AFC playoff hunt, but until they prove they can beat the Chiefs and deliver in big games, their NFL betting profile will remain that of an intriguing but flawed contender. Week 1 in Brazil gives them the perfect opportunity to change that narrative.

2025 Los Angeles Chargers Schedule, Results & Record

The Chargers outperformed the talent level on the roster last season to make it to the playoffs, where they promptly played to the talent level on the roster and quickly bowed out. Given Jim Harbaugh coaches them, gamblers put strong money on them maximizing their regular-season performance in just about any given season.

Given Harbaugh's general philosophy, it was surprising to see them invest in offensive skill players with their first two draft picks. They emerged from the draft still having question marks on the interior of the offensive and defensive lines. This is a team that got better, but given the amount of resources that were on hand, it probably could have done even more.

Los Angeles Chargers Past Seasons (2000)

Founded in 1960 as charter members of the American Football League, the Los Angeles Chargers moved to San Diego in 1961. Barron Hilton, an heir to the famous hotel chain, was the original owner. He named the team the Chargers after his credit card company, which was aligned with his hotels and restaurants. The early Chargers were the power of the American Football League. Their marquee man was Hall of Fame receiver Lance “Bambi” Alworth. Head coach Sid Gilman was a pioneer in passing game development. The Chargers played in the first two AFL championship games, losing both. Finally, they won the 1963 AFL championship. After losing the AFL championship game in the next two years, the Chargers went into a long period of darkness.

But head coach Don Coryell and quarterback Dan Fouts led a franchise resurgence in the early 1980s. Following that was another long period of losing. The Chargers made their only Super Bowl appearance in the 1995 season, losing to the 49ers.

From 2004 through 2018, the Chargers made the playoffs seven times. For most of those years, the quarterback was Philip Rivers, who could never get the Chargers to the Super Bowl.

Finally, after years of futility in trying to get a new stadium built, the Chargers returned to LA from San Diego in 2017.

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