2025 NFL Week 3 Best Bets - Football Lines
Through the first two weeks of the NFL season 10 teams are undefeated. With three teams at 2-0 the NFC West is the only division with more than one unbeaten. That will change in Week 3 with a matchup between the Arizona Cardinals and San Francisco 49ers. Playing without Brock Purdy and George Kittle, the Niners beat the Saints 26-21 with both wins coming on the road. The Cards opened with consecutive wins for the first time since starting the 2021 season with seven straight victories. In a playoff rematch from last season the LA Rams and defending Super Bowl champion Philadelphia Eagles look to remain unbeaten in the only other Week 3 tilt featuring teams without a loss.
The betting week opens with an AFC East clash between the Miami Dolphins and Buffalo Bills. Josh Allen didn’t need to be the hero in Sunday’s 30-10 dismantling of the Jets. Instead the Bills got 132 yards and two TDs rushing from James Cook and the defense held New York to just 154 total yards. The Bills are on their way to a sixth straight division title and have the biggest point spread on the early Week 3 line spotting the winless Dolphins 12-points. The only game between teams without a win takes place on Sunday Night Football when the Chiefs visit the Giants. For the first time since Patrick Mahomes became the full-time starter the Chiefs opened with consecutive defeats. They are favored by 6-points to break the spell.
NFL Betting Lines
Ready to Bet on the NFL?
Bet 2025 NFL odds at BookMaker—spread bets, totals, player props, and futures all season long.
* Trusted by sharp bettors for over 30 years
* Early odds, fast payouts, and Bitcoin betting
* Live betting and mobile-optimized sportsbook
* Don’t just watch the action — bet on it!
* Sign Up Now and lock in your NFL picks today!
2025 NFL Week 3 Betting Lines
*Odds as of Tuesday, September 16, 3:00 PM ET
Has the Chiefs run of dominance in the AFC come to an end? It’s still early and there were encouraging signs in their Super Bowl rematch with the Eagles on Sunday. If not for a pass that hit off the hand of Travis Kelce and was intercepted, we would be having a different discussion. But that’s the way the ball bounces, as they say, and the Chiefs need to get more out of their offense. Mahomes has completed less than 59 percent of his throws through two games and has been the team’s leading rusher in both.
As much as the NFL tries to protect QBs sometimes it just can’t. The Cincinnati Bengals are one of the unbeaten teams but they’ll have to navigate the next few months with backup Jake Browning running the offense. Several starters got hurt and will be out or questionable in Week 3, including Joe Burrow. Browning threw two scoring passes leading the Bengals to a comeback win over Jacksonville on Sunday, but he also tossed three picks. He’s familiar with the role having started seven games in place of Burrow in the 2023 season.
Teams know the importance of having a capable backup QB so losing the starter isn’t a death sentence. Behind Mac Jones the Niners won and covered against the Saints in Week 2. Washington, Minnesota and the Jets could all be impacted without their QB1. The Commanders are a 6.5-point favorite over the Raiders and the Vikings are giving Cincy 1.5-points. On the road for the first time the Jets are a 6.5-point dog to Tampa Bay.
Underdogs earned payouts in seven Week 2 games with five of those teams winning outright. Seattle at +4 was the biggest dog to win upsetting Pittsburgh. Carolina scored the final 19 points in a 27-22 loss to get within the 7.5-point line against Arizona. There was a shift on the over/under from Week 1. Teams cashed the UNDER in 12 of 16 games opening weekend but that trend exploded in Week 2 with the OVER going 10-6.
The betting week closes with an interconference matchup between contenders Detroit and Baltimore. Both teams rebounded from a loss with impressive Week 2 wins. Detroit scored 52 points for the third time in their last 13 regular season games stomping the Bears. And Baltimore is the only team to score at least 40 points in each of their first two contests. And that’s why the early total of 52.3 is the highest on the Week 3 board.
NFL Schedule
Did You Know?
At BookMaker, we go beyond just providing top-notch sports betting options! Take advantage of these exclusive features and rewards:
BookMaker ATM Card for seamless transactions: Easily access your funds with the BookMaker ATM card, providing instant access to your winnings and secure transactions wherever you go.
Loyalty Levels & BetPoints Programs for additional rewards: Earn BetPoints as you bet, and unlock exciting perks at higher loyalty levels. The more you play, the more you earn!
Seasonal and Reload Bonuses to maximize your earnings: Stay ahead with seasonal promotions and reload bonuses, boosting your bankroll throughout the year.
Early Cashout Option for added flexibility: Cash out your bet early and lock in profits or limit losses—putting you in control of your wagers.
Free Crypto Payouts for fast and secure withdrawals: Enjoy fast, secure withdrawals with zero fees when you choose crypto payouts.
Open Play Option for unique parlay betting: Get creative with your parlays using the Open Play option, offering more ways to win.
Casino Promotions & Contests for extra fun and wins: Join in on exclusive casino promotions and contests, adding excitement to your betting experience.
8% Cash Back on all your horse racing bets: Place horse racing bets and get 8% cash back on your losses, making it easier to bounce back.
Explore all these benefits and more at BookMaker!
Betting Rules & Policies
Free Play Rules
- Free plays cannot be used on proposition bets.
- Free Plays do not earn any BetPoints™
- Bets made using Free Plays do not count towards completing any rollovers. (Free Plays are always subject to a rollover of their own. You must complete the required rollover prior to making a withdrawal).
- The maximum payout for any Free Play is $5,000.
- Free Plays that are left unused for 180 days will be removed from your account.
ROLLOVER
- Did you know that on all deposits made at BookMaker, there is a rollover requirement: an amount of betting action you must fulfill before you are eligible to make a withdrawal.
- Did you know that rollovers are calculated by multiplying the amount initially credited to your account a certain number of times? Yes! If you deposit without claiming any bonus, the rollover will always be 1x (one-time) your deposit amount. If you do claim a deposit bonus, the rollover will be higher and is based on the deposit plus bonus amount.
Wager disputes (claims)
If you disagree with any aspect of a wager you’ve placed, you are welcome to log an official dispute (commonly known as a “claim”). Claims must be reported no later than 15 (fifteen) calendar days following the settlement of the wager.
If following an initial review of the case there remains any doubt regarding the wager type, line, market, amount, or any other detail, the claim will be escalated to the BookMaker management team. All decisions made by them are final.
Wager Cash Out - How it works
With the Cash Out feature you can choose to eliminate a wager that's already been placed, and receive back either a portion, or your full stake amount.
Cash Out is selectively available on certain events, fixtures, and markets.
In order to see if a wager is eligible to be cashed out, simply navigate to your Bet Slip and check the 'My Open Bets' tab. If eligible, the Cash Out button will be displayed.
It’s also important to note that Cash Out is not contributing to any bonus or promotion including Bet Point accumulation and Rollover for releasing bonus cash.
