Detroit Lions Week 1 Best Bets - NFL Betting Lines

Detroit Lions Week 1 Best Bets - NFL Betting Lines

The Detroit Lions enter the 2025 NFL betting season as one of the NFC’s top contenders and a team that has quickly become a staple for bettors. After posting a dominant 2024 campaign, Detroit now sits near the top of the futures market. The Lions currently carry +967 odds to win the Super Bowl, are priced at +480 to win the NFC Championship, and are listed as +144 favorites to capture a third straight NFC North title. Their season win total is set at 10.5 games, a number that reflects lofty expectations but also confidence from oddsmakers that Detroit will remain a force. Lions Fans can now wager on the NFL using crypto across BookMaker Sportsbook.

Head coach Dan Campbell has reshaped the franchise’s identity, blending toughness with creativity on both sides of the ball. The offseason did bring changes, as both of Campbell’s coordinators moved on to head coaching positions, leaving the Lions to adjust at the top of their staff. Still, the roster remains one of the most balanced in football, with young stars on offense and a defense that grew into one of the NFC’s more reliable units.

Packers vs. Lions Week 1 Betting Lines

Spread: Packers -1

Total: 49

Money Line: Packers -125, Lions +105

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Detroit Lions Week 1 Matchup

On Sunday, September 7, 2025, the Detroit Lions will travel to Lambeau Field in Green Bay, Wisconsin to face the rival Packers. Kickoff is set for 4:25 p.m. ET with television coverage on CBS. Oddsmakers opened the matchup as a pick ’em, but early action has swung the line toward Green Bay, with the spread now listed at Packers -2 at heavier juice. The total has climbed from 47.5 to 49.5, suggesting bettors anticipate offensive fireworks in this first of two NFC North showdowns.

The rivalry between Detroit and Green Bay has tilted in the Lions’ favor of late. Detroit has won and covered in six of the last ten meetings at Lambeau, including a pair of convincing victories last season. Their ability to dominate the trenches and dictate pace has been the difference, and the Lions will look to continue that trend against a Packers team eager to reclaim divisional bragging rights.

Injuries will play a role. Tight end Sam LaPorta is listed as questionable, along with tackle Taylor Decker and rookie corner Terrion Arnold. Linebacker Malcolm Rodriguez is on the PUP list, leaving depth concerns in the middle of the defense. Even so, the Lions enter with one of the NFC’s deepest rosters, and Campbell’s aggressive style has proven successful against Green Bay.

From a betting perspective, Detroit brings with it one of the strongest road profiles in the NFL. The Lions have gone 9–1 straight up and ATS in their last ten road games, with Overs hitting in five of those contests. Against Green Bay specifically, Detroit is 6–4 straight up and 7–3 ATS in their last ten trips to Lambeau, a clear sign they’ve shed the label of being an easy divisional out.

The Week 1 storyline is about validation. Can Detroit maintain its hold on the NFC North despite losing its coordinators, or will the Packers exploit any early-season instability? With line movement leaning Green Bay, oddsmakers suggest this opener will be a tight, high-scoring affair — exactly the kind of test that can define the Lions’ season trajectory.

Detroit Lions 2024-25 Recap

Detroit’s 2024 campaign was the best in modern franchise history. The Lions closed the year 15–2 straight up, 11–5 against the NFL spread, and 9–6–1 to the Over, cementing themselves as one of the NFL’s most complete teams. The offense thrived behind Jared Goff’s efficiency, Amon-Ra St. Brown’s emergence as an elite wideout, and a two-headed rushing attack that ranked among the league’s most productive. Defensively, Detroit grew more reliable each week, developing into a unit capable of closing games rather than letting opponents hang around.

The betting markets consistently underrated Detroit. Their 11 covers in 17 games reflected a team that exceeded oddsmakers’ expectations, while the balance of Overs and Unders showed versatility. Bettors were rewarded whether the Lions won shootouts or defensive struggles. Their ability to perform in both environments was a major reason for their rise from NFC hopeful to legitimate Super Bowl contender.

Campbell’s leadership was the through line. His willingness to take risks galvanized the locker room and gave the Lions a swagger they had lacked for decades. That confidence carried into big games, where Detroit consistently delivered. The 15–2 record was not simply about talent — it was about culture, resilience, and belief.

Heading into 2025, the Lions no longer fly under the radar. They are priced as one of the NFC’s best and carry the burden of expectation. Their Week 1 trip to Lambeau will set the tone, not only for their divisional race but also for whether Detroit can handle being the hunted rather than the hunter. The 2024 season proved they belong among the elite. Now the 2025 campaign will test if they can take the next step toward the franchise’s first Super Bowl appearance.

2025 Detroit Lions Schedule, Results & Record

The Lions missed an opportunity to add help for Aidan Hutchinson, the star edge rusher recovering from a leg injury. Alim McNeill is also working his way back from a significant injury. The secondary this season could be defined by how much 2024 draftees Terrion Arnold and Ennis Rakestraw Jr. improve in Year 2. The Lions also have to get on the same page with veteran newcomer Reed, who signed a three-year deal after a successful stint with the New York Jets.

Detroit Lions Past Seasons (2000)

Founded in 1932, the Detroit Lions have a lot of history, though most of it is for their ineptitude. Once upon a time, the Lions were a power franchise in the NFL.

From 1952 through 1957, the Lions won three NFL championships. Unfortunately for Detroit, that last title in 1957 is not remembered except by its elderly fans. Detroit has never made the Super Bowl since the game's inception in the 1966 season.

The Lions may not have won many championships, but they have had many memorable star players through the years. Bobby Layne was the Lions' quarterback in their 1950s era of glory.

In the late 1960s and early 1970s, the Lions had some tough teams that were pretty good, including their 1970 playoff team. Those teams had big-name stars such as cornerback Lem Barney, defensive tackle Alex Karras, cornerback Dick LeBeau, linebacker Joe Schmidt, center Ed Flanigan, kicker Errol Mann, and tight end Charlie Sanders.

The Lions were such an attractive team in that era they were featured in a major motion picture. Alan Alda starred in Paper Lion as the writer who tried out for the team and chronicled his training camp experience in a book.

In later years, the Lions had to of the most exciting running backs in NFL history. Billy Sims and Barry Sanders electrified fans and gamblers with their exploits.

In 1991, the Lions had their closest shot at a Super Bowl. Detroit made the NFC championship game but was eliminated by the eventual champion Washington Redskins.

Wayne Fontes coached that Lions team and led Detroit to the playoffs four times from 1991 through 1995.

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