NFL Week 6 Betting Online
Week 6 of the 2025 NFL season opens with a Thursday night Prime Video matchup of the New York Giants hosting the Philadelphia Eagles. This NFC East rivalry dates back to the pre-Super Bowl era and has produced some of the best games in league history. This year, fans and gamblers expect a mismatch between the defending Super Bowl champion Eagles and a Giants team coming off two horrible seasons after an improbable 2022 playoff run. Certainly, the Giants will be an interesting team with Russell Wilson taking over at QB with Jameis Wilson and first-round draft pick Jaxson Dart behind him.
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2025 NFL Week 6 Schedule
TEAMS ON BYE: Texans & Vikings
In the early Sunday afternoon window, one of the NFL’s greatest and most ancient rivalries will be renewed when the Pittsburgh Steelers host the Cleveland Browns. Both teams are unsettled at quarterback, and that will add to the intrigue. The Steelers may still sign Aaron Rodgers as a quick fix at quarterback, but otherwise have a list of mediocre alternatives led by Mason Rudolph. Cleveland has Shedeur Sanders on its roster, and he is the people’s choice, but veteran Joe Flacco may make the most sense as a proven winner.
Speaking of quarterback intrigue, the Miami Dolphins will host the LA Chargers in the early Sunday window as well. Justin Herbert continues to grow under head coach Jim Harbaugh, while Tua Tagovailoa is a threat anytime he takes the field for Miami. However, that is the problem: Tua is often injured, and that has been Miami’s biggest problem to overcome.
The Chargers made the 2024 NFL Playoffs in Harbaugh’s first season to spark hope for the future. The Kansas City Chiefs' AFC West dynasty can’t last forever, and the Chargers will fill that void when the time comes.
The Dolphins rank as one of the worst organizations in the NFL, if not all of sports. Mike McDaniel returns as head coach after everyone called for his firing. McDaniel runs one of the softest teams in football and is coming off an 8-9 season that failed to produce a playoff spot.
In the late afternoon window, an outstanding interconference matchup features the Cincinnati Bengals at the Green Bay Packers. Lambeau Field will host a potential Super Bowl preview with two of the best quarterbacks in the NFL. Cincinnati’s Joe Burrow and Green Bay’s Jordan Love make for a potential shootout.
Cincinnati head coach Zac Taylor produced a 2021 AFC championship and a near miss for a second one in 2022. But Taylor is under fire for the perception that the Bengals have underachieved under Taylor. Of course, part of the problem has been injuries to Burrow. Still, this is a critical season for Taylor.
Green Bay HC Matt LaFleur is also getting increased scrutiny. LaFleur has a 67-33 career record and jump-started the franchise after Mike McCarthy flamed out, but is yet to produce a Super Bowl berth, and the 2024 season was seen as a step back with a meek wild-card round loss.
Sunday Night Football offers a potential Super Bowl preview with the Kansas City Chiefs hosting the Detroit Lions. Last year, in the season opener, the Lions won at Kansas City to set the tone for both teams. Kansas City remains one of the best home-field atmospheres in sports, but the Lions will not be intimidated and could offer enhanced betting value.
NFL Schedule
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