2025 NFL Week 6 Best Bets - Football Lines

2025 NFL Week 6 Best Bets - Football Lines

The 1972 Dolphins can celebrate early after the remaining two teams without a loss were upset at home leaving no unbeaten clubs entering Week 6 of the NFL season for the first time since 2014. The clock finally struck midnight on the defending Super Bowl champion Eagles, who fell to Denver 21-17. They had been playing with fire winning each of their first four games by seven points or less. It’s a short turnaround for Philly as they open the betting Week with a Thursday Night Football matchup against NFC East opponent the New York Giants as a 7.5-point road favorite. After upsetting the Chargers in Week 4, the G-Men returned to their losing ways falling to previously winless New Orleans. This is one of only two divisional games on the Week 6 slate with Pittsburgh hosting Cleveland on Sunday in an AFC North contest being the other.

Only one team remains without a win entering Week 6 and putting the Jets in an International Series game is probably not the best way for the NFL to show off its product. New York is the designated home team in London for its early Sunday game against the Denver Broncos. Following their upset of Philadelphia, the Broncos opened as an 8-point favorite. The Sunday Night Football contest looks like it could be a doozy with the surging Detroit Lions visiting Kansas City. The Chiefs fell back under .500 with a loss to Jacksonville while the Lions have four straight payout wins scoring at least 34 points in every game.

For the third time this season the betting week closes with a Monday Night Football doubleheader. It’s been more than a year since the Bills lost consecutive games and they’ll look to avoid that with a game against the Falcons. Starting at 8:15 p.m. ET an hour after the first MNF game kicks off, the Chicago Bears come off their bye to face the Washington Commanders. It was around this time last season the Bears came off their bye with a 4-2 record and faced Washington. They lost on a last second Hail Mary starting a 10-game losing streak.

NFL Betting Lines

2025 NFL Week 6 Betting Lines

TEAMS ON BYE: Texans & Vikings

*Odds as of Tuesday, October 7, 1:00 PM ET

Byes continue in Week 6 with the Vikings and Texans off. Those teams were two of 10 visiting clubs to win in Week 5 making it a good one for the road teams. The Tennessee Titans were one of seven upset road winners getting plenty of help from Arizona in their 22-21 victory. The Titans were an 8-point dog and have gotten at least 5.5-points in every game. Though they have the same record at the Las Vegas Raiders, the Titans are catching 5-points on the early line in their Sunday matchup.

The AFC South boasts two of the conference’s three 4-1 teams in the surprising Indianapolis Colts and Jacksonville Jaguars. Giants castoff Daniel Jones leads the NFL’s second highest scoring offense completing more than 71 percent of his passes for 1,290 yards. The Colts scored at least 40 points for the second time in three games crushing Vegas 40-6 on Sunday. Indy is 4-1 ATS and is a 6.5-point home favorite on the early line against the Cardinals.

The Jags broke an 8-game losing streak to KC with their 31-28 win on Monday night reaching the 30-point mark for the first time in their last 15 games. The Jags are 4-1 for the first time since the 2007 season and have four payouts. Their streak of games with multiple takeaways ended, but Jacksonville made their one forced turnover count against the Chiefs. Devin Lloyd took his NFL leading fourth interception 99-yards for a TD. The Jags are 3-0 SU and ATS at home and host Seattle as a 1.5-point early favorite on Sunday.

The promising start for Cincinnati has turned into a nightmare after the injury to Joe Burrow. For the second time in four games since taking over for Burrow, Jake Browning threw three interceptions and the Bengals lost their third straight. The Bengals head to Green Bay as a 15-point underdog, which would be the largest point spread in any game this season. Cincy failed to stay within the 10.5-point spread in a 37-24 loss to the Lions dropping them to 1-4 ATS this season. Double digit favorites are 5-0 SU and 3-2 ATS this season.

NFL Schedule

• Week 1
• Week 2
• Week 3
• Week 4
• Week 5
• Week 6
• Week 7
• Week 8
• Week 9
• Week 10
• Week 11
• Week 12
• Week 13
• Week 14
• Week 15
• Week 16
• Week 17
• Week 18

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