2025 NFL Week 12 Online Betting - Football Picks

NFL Week 12 Betting Online

NFL Week 12 Betting Odds

Prime Video opens Week 12 with an AFC matchup of playoff teams from last year. The Buffalo Bills have been perennial Super Bowl contenders for the past several years. This year could finally be the year for head coach Sean McDermott and quarterback Josh Allen. Buffalo has been written off for dead many times since their 2022 playoff debacle, yet they always come back for more. The Bills are the most resilient franchise in the NFL. Meanwhile, the Houston Texans have been transformed under the leadership of head coach DeMeco Ryans and quarterback CJ Stroud. After several years of failure, the Texans are coming off two playoff seasons and are favored for more.

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2025 NFL Week 12 Schedule

MATCHUP TIME (ET) TV
Thursday, November 20
Bills at Texans 8:15 PM Prime Video
Sunday, November 23
Jets at Ravens 1:00 PM CBS
Steelers at Bears 1:00 PM CBS
Patriots at Bengals 1:00 PM CBS
Giants at Lions 1:00 PM FOX
Vikings at Packers 1:00 PM FOX
Colts at Chiefs 1:00 PM CBS
Seahawks at Titans 1:00 PM FOX
Jaguars at Cardinals 4:05 PM CBS
Browns at Raiders 4:05 PM CBS
Eagles at Cowboys 4:25 PM FOX
Falcons at Saints 4:25 PM FOX
Buccaneers at Rams 8:20 PM NBC
Monday, November 24
Panthers at 49ers 8:15 PM ESPN/ABC

TEAMS ON BYE: Broncos, Chargers, Dolphins & Commanders

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In the early Sunday window, the Kansas City Chiefs will host the Indianapolis Colts in what could be a playoff preview. The Colts are an interesting team with new quarterback Daniel Jones arriving from the New York Giants, where he was never truly accepted and never had a serious supporting cast surrounding him. Jones had one big year in 2022 when he led the Giants to the NFC divisional round. But after getting a big contract for his efforts, Jones and the Giants fell hard and fast. Now he gets a new lease on life and has far less pressure and scrutiny with the Colts. Indy head coach Sean Steichen faces a critical third year on the sidelines after two seasons out of the playoffs.

The Chiefs have owned the AFC West since 2016, but there is a sense that the rest of the division is catching up. Fans and gamblers are asking if TE Travis Kelce can bring himself together for one big final season of glory after battling through injuries in 2024 and being on a milk carton for the Super Bowl. Quarterback Patrick Mahomes is also under increased scrutiny after a miserable Super Bowl performance.

One of the great NFL rivalries will be renewed in the early Sunday window when the Green Bay Packers host the Minnesota Vikings at Lambeau Field. This could be one of the most important matchups with potential playoff implications.

Minnesota is coming off a 14-3 season that ended in a bizarre playoff flop against the Los Angeles Rams. Despite the success, Minnesota tried to trade its starting quarterback, Sam Darnold, as the impressive season was taking place. Darnold has since left for the Seattle Seahawks, making JJ McCarthy the starter.

In the late afternoon, the Dallas Cowboys will host the Philadelphia Eagles in an NFC East rivalry showdown. By this time, we will know if the Eagles have a Super Bowl hangover or are primed for another serious look at a championship run. In comparison, the Cowboys will be deep into their first season under Brian Schottenheimer, and whether or not that was a good hire. The best thing going for the Cowboys in 2025 is low expectations.

NBC Sunday Night Football features a potential playoff preview between the Tampa Bay Buccaneers and the Los Angeles Rams in LA. The Rams are coming off two consecutive playoff seasons but are nowhere near the level of their 2021 Super Bowl championship campaign. Tampa Bay is also coming off five consecutive playoff seasons, including three in a row by current head coach Todd Bowles. Baker Mayfield has resurrected his career as a quarterback in one of the great NFL comeback stories. But the Buccaneers still lack cachet with a skeptical public.

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