New Orleans Saints Week 1 Best Bets - NFL Betting Lines

New Orleans Saints Week 1 Best Bets - NFL Betting Lines

The New Orleans Saints enter 2025 with futures markets signaling a steep climb. The Super Bowl price opened at 100-1 and has drifted to +26643, the NFC Championship line moved from +8000 to +14256, and NFC South odds widened from +700 to +1500. The win total opened and holds at 5.5, reflecting modest expectations and balanced action. BookMaker Sportsbook now offers Bitcoin deposits and withdrawals for Saints fans betting on the NFL futures odds using crypto.

New Orleans’ path forward hinges on steadier quarterback play and a cleaner offensive identity. The offense returns a capable skill group—Chris Olave as the alpha target and Rashid Shaheed stretching the field—while new head coach Kellen Moore’s staff works to reestablish efficiency on early downs so drives don’t die behind the sticks. Alvin Kamara still gives this offense a multipurpose outlet; his value shows up as much in pass-pro and outlet work as in splash plays. The offensive line’s cohesion is the swing factor. When healthy, the unit can keep either of Spencer Rattler or rookie Tyler Shough on schedule and allow tempo; when it leaks, the Saints’ scoring ceiling shrinks and totals skew Under.

Defensively, New Orleans remains veteran-led. The front’s ability to win early downs and force third-and-long scenarios is critical, especially with a secondary that performs best when pass rush and coverage stay married.

Saints vs. Cardinals Week 1 Betting Lines

Spread: Cardinals -6

Total: 42.5

Money Line: Cardinals -270, Saints +222

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New Orleans Saints Week 1 Matchup

On Sunday, September 7, 2025, the Saints host the Arizona Cardinals from the Caesars Superdome in New Orleans, Louisiana. Kickoff is set for 1:00 p.m. ET with television coverage on CBS. The Week 1 NFL odds opened Saints +2 at home but have steamed to +6, a strong signal that the market is confidently fading New Orleans early. The total opened 43.5 and has dipped to 43, in line with expectations of a grind rather than a track meet.

As hosts, the Saints are 4–6 straight up and 5–5 ATS across their last ten, indicating no real betting edge in the Superdome. As an underdog, they’ve struggled: 2–7 SU and 3–6 ATS in their last nine catching points, which helps explain the sharp push from +2 to +6. The Under has cashed in seven of their last 10 overall, aligning with the current move from 43.5 to 43 and the broader profile of a team that often plays to script defensively but stalls offensively.

Arizona debuts a new-look offense under Kellen Moore with Shough or Rattler stepping in as QB1. First-start volatility is real, yet Moore’s structure tends to generate clean answers on early downs. For the Saints, that puts stress on the rush/coverage marriage—get pressure with four and muddy the first read, or risk on-schedule chunk plays. Offensively, New Orleans should test Arizona’s linebackers and slot defenders with choice routes and angle concepts for Kamara, plus intermediate crossers to Olave that punish single-high looks. If New Orleans wins on first down and avoids third-and-long, the +6 can hold value; if drives stall, the market’s Under lean likely proves correct.

Injuries of note include Alontae Taylor (Q), Devin Neal (Q), and Taysom Hill (Q). Taylor’s availability affects how aggressively the Saints spin the dial in coverage; Hill’s multipurpose role is a red-zone and short-yardage lever; Neal’s status impacts rotational balance in the backfield and special teams. If two or more sit, the spread and total angles both tilt toward Arizona and the Under.

New Orleans Saints 2024-25 Recap

New Orleans finished 5–12 straight up, 7–10 ATS, and 8–9 to the Over/Under. The profile fit the tape: competitive stretches on defense, too many empty possessions on offense, and a narrow margin for error that produced more close losses than covers. There were genuine bright spots. Chris Olave continued an ascent toward elite status, separating at all three levels and carrying the passing game through inconsistent quarterback rhythm. Linebacker Pete Werner took another step, providing range and reliability that stabilized the second level. Those “bust out” notes matter because they translate to bettable angles: Olave props and intermediate passing scripts in neutral scripts; Werner-led structure that helps Unders cash when the offense can’t sustain pace.

For 2025, the 5.5-win total lines up with a team that must stack small edges: fewer negative plays on first down, fewer protection busts, and more red-zone conversion. If either quarterback, Olave, and Kamara get that early-down efficiency bump and the defense finishes drives, the Saints can nibble toward the Over and keep spreads inside one score. If not, the market will keep pushing against them—as Week 1’s move from +2 to +6 already implies.

2025 New Orleans Saints Schedule, Results & Record

The Saints have had a strange offseason, starting with their decision to keep Derek Carr on the roster, guaranteeing more money on his contract after back-to-back losing seasons in New Orleans. It was all set up for the Saints to finally undergo a full rebuild for the first time since Drew Brees joined the team in 2006. Instead, new coach Kellen Moore finds himself with a disgruntled quarterback after reports emerged of Carr possibly wanting out.

New Orleans gave itself another quarterback option with the second-round selection of Tyler Shough, perhaps the most pro-ready signal-caller from this year’s draft class. But it took Shough seven years to produce his best season in college after dealing with a handful of injuries. The team could be asking a lot of its rookie—second-year quarterback Spencer Rattler could be another option. To make matters worse, starting wideouts Chris Olave and Rashid Shaheed are working their way back from an injury-filled 2024.

Bringing back Brandin Cooks might not be enough for an offense that could again rely heavily on running back Alvin Kamara, the ninth-year veteran. The veteran-filled defense didn’t get much help outside of the signing of Reid.

New Orleans Saints Past Seasons (2000)

Founded in 1967 as an expansion team, the New Orleans Saints have a colorful history of ineptitude and glory.

In the initial years of the franchise, the Saints could not find their way. New Orleans did not post a winning record until the 1987 season. Those two decades of losing featured one of the most popular players in franchise history.

Quarterback Archie Manning remains a legend to this day. Manning was a star on some really bad teams, and Saints fans never stopped appreciating his efforts against hopeless odds.

Jim Mora was the head coach of the first serious iteration of the Saints. Mora led the franchise to its first four playoff berths. New Orleans was a serious contender for the first time in franchise history in the Mora era that ran from 1986 through 1995.

Sean Payton took over the team in 2006 and led the Saints to their most successful period in team history. From 2006 through 2020, the Saints made the NFL Playoffs nine times. New Orleans won the 2009-10 season Super Bowl, the only title in franchise history.

Payton was the head coach during the infamous Bountygate scandal and was suspended for an entire season. But by the time he retired, all of that was forgotten. Payton partnered with quarterback Drew Brees for one of the NFL’s most prolific offenses. Both coach and quarterback are likely Hall of Fame-bound. Gayle Benson, the widow of deceased legendary owner Tom Benson, remains the team's owner. John Mecom Jr. was the original owner who put colorful but losing teams on the field.

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