NFL Week 1 Betting Odds: Point Spreads, Money Lines and Totals

NFL Week 1 Odds: Spreads, Moneylines, Totals

NFL Week 1 Betting Picks

Naturally, the NFL uses its opening weekend for maximum exposure with attractive games that generate instant momentum for the rest of the season. That is certainly the case for the 2022 campaign.

It all begins with the traditional NBC Thursday night game. The Buffalo Bills will visit the defending Super Bowl champion Los Angeles Rams. This game serves as more than a kickoff to the NFL regular season though. It also kicks off the new NBC Sunday Night Football broadcast team. Mike Tirico replaces the legendary Al Michaels as the play-by-play man, with the venerable Cris Collinsworth still in the fold as the color commentator. Additionally, Melissa Stark will be the new sideline reporter, taking over for the retired Michele Tafoya.

As for the game itself, the Bills are coming off a great regular season that ended in excruciating heartbreak. Buffalo’s overtime loss in the divisional playoffs at Kansas City was one of the greatest games in NFL history. It was also a defeat so cruel that the Bills will be severely tested to move on from it.

The Los Angeles Rams are coming off the high of their first Super Bowl championship in the City of Angels. The Rams' previous Super Bowl title was won in St. Louis.

The Thursday night game pits two of the best quarterbacks in the NFL with Josh Allen of the Bills and Matthew Stafford of the Rams. NBC and the NFL have a gem of an opener, and sportsbooks are smiling about the massive handle that this game will generate.

Week 1 NFL Betting Lines and Schedule

SPREAD TOTAL MONEY LINE
Thursday, September 8 - 8:20 PM
Bills (-2.5) at Rams 52.5 Bills -140, Rams +120
Sunday, September 11 - 1:00 PM
Ravens (-7) at Jets 44.5 Ravens -315, Jets +256
Saints (-5) at Falcons 42.5 Saints -220, Falcons +184
Patriots at Dolphins (-3) 46.5 Patriots +135, Dolphins -155
Browns at Panthers (-2.5) 41.5 Browns +125, Panthers -145
Steelers at Bengals (-6.5) 44.5 Steelers +241, Bengals -295
49ers (-7) at Bears 41.5 49ers -313, Bears +255
Eagles (-4) at Lions 48.5 Eagles -200, Lions +170
Colts (-8) at Texans 46 Colts -380, Texans +303
Jaguars at Commanders (-3) 44 Jaguars +140, Commanders -160
Sunday, September 11 - 4:25 PM
Chiefs (-4.5) at Cardinals 53.5 Chiefs -200, Cardinals +170
Raiders at Chargers (-3) 52 Raiders +151, Chargers -175
Packers (-2) at Vikings 48 Packers -131, Vikings +111
Giants at Titans (-5.5) 43.5 Giants +199, Titans -240
Sunday, September 11 - 8:20 PM
Buccaneers (-1) at Cowboys 50 Buccaneers -123, Cowboys +103
Monday, September 12 - 8:15 PM
Broncos (-6.5) at Seahawks 43.5 Broncos -277, Seahawks +227

*Odds as of Monday, September 5, 9:00 AM ET

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One of the most interesting games of Week 1 will pit the New England Patriots against the Miami Dolphins. New England has dominated the AFC East for a little over two decades under Bill Belichick, but this offense looked woeful in training camp and in the preseason. Mac Jones may not have progressed like many were hoping in his second season, while Miami could challenge Buffalo for supremacy in the division. The Dolphins traded for Tyreek Hill to give Tua Tagovailoa an explosive receiver, and that could make this offense much better in 2022.

Another one of the more intriguing games will feature the Detroit Lions taking on the Philadelphia Eagles. Detroit was going to get a bump this offseason due to the way they finished the 2021 season, and there is even more love because of the ‘Hard Knocks’ appearance. Many are calling on the Lions to be a sneaky playoff contender in 2022, but there isn’t a lot of talent on the roster.

Baker Mayfield will face his former team in another early game on Sunday. Mayfield was traded to Carolina for a conditional pick in the 2024 NFL Draft back in July, and he beat out incumbent Sam Darnold for the starting job. The Browns were hoping to have Deshaun Watson for this game, but he has now been suspended for 11 games, leaving Jacoby Brissett to steer the franchise in Watson’s absence.

Two of the most exciting quarterbacks in the league will meet in one of the premier late afternoon tilts as Patrick Mahomes and the Kansas City Chiefs face Kyler Murray and the Arizona Cardinals. Kansas City has made it to the AFC Championship Game for four straight seasons, but the franchise has only won one Super Bowl. Meanwhile, Arizona would love to get back to the Super Bowl, as this has been one of the least successful teams in the NFL although they are older than any other franchise.

For the second straight season, Tampa Bay and Dallas will meet in Week 1. The Buccaneers and Cowboys played in Tampa for last year’s season opener, so it’s only right that the Cowboys are the hosts this time. They are slight home underdogs to the Bucs though as Dallas has been really hurt by injuries this preseason.

This week will close out with the Seattle Seahawks playing host to the Denver Broncos on Monday Night Football. Seattle hit the reset button by trading star quarterback Russell Wilson to Denver this offseason, so fans in attendance are going to have dual loyalties. The Seahawks are almost a touchdown underdog at home, as they are expected to be one of the worst teams in the NFC.

NFL Schedule

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