NFL Week 1 Spreads, Money Lines and Totals
Week 1 begins with the traditional Thursday night opener on NBC, and it is a marquee matchup. The defending Super Bowl champion Philadelphia Eagles will host the Dallas Cowboys in the renewal of one of the NFL’s greatest rivalries. The Cowboys are coming off a lost season that cost head coach Mike McCarthy his job. Owner Jerry Jones is now in his early 80s, running out of time, and desperate for a farewell Super Bowl championship. Rookie head coach Brian Schottenheimer faces a tall task in jumpstarting the Cowboys' efforts to be a serious Super Bowl contender. A Week 1 matchup at Philadelphia will be quite the baptism for Schottenheimer, who was a compromise choice after Jones failed to land a big fish, most likely over control of the roster and football decisions. Philadelphia opened as one of the future market favorites to win the Super Bowl come February. The Eagles' dominant win over the Kansas City Chiefs is impossible for the masses to ignore. Last year, the Eagles dominated the Cowboys, winning both meetings by a combined score of 75-13.
NFL Betting Lines
2025 NFL Week 1 Spreads, Money Lines & Totals
*Odds as of Monday, May 19, 1:00 PM ET
The second game of the season takes place on Friday night when the Kansas City Chiefs meet the Los Angeles Chargers in Brazil. These teams were charter members of the American Football League in 1960 and have shared the same division ever since. Los Angeles showed profound improvement in 2024 under head coach Jim Harbaugh, who enters his second season facing high expectations and possibilities with quarterback Justin Herbert.
The Chiefs are on a mission to redeem themselves for their humiliating Super Bowl loss to the Eagles last February. Kansas City was outcoached and outplayed and blew the opportunity to win an unprecedented third consecutive Super Bowl title. Head coach Andy Reid, QB Patrick Mahomes, TE Travis Kelce, PK Harrison Butker, and the rest of the Chiefs vow to make it back to Super Sunday and redeem themselves.
The Las Vegas Raiders and New England Patriots are coming off terrible seasons that forced coaching changes. Two seasoned veterans and proven winners will be making their debuts in week 1 at Gillette Stadium. Pete Carroll took off last year after a long and successful run with the Seattle Seahawks. Now he is the head coach of the Raiders, giving them instant credibility and valuable HC experience. The same holds with Mike Vrabel, who led the Tennessee Titans to one of their most successful eras before running out of steam two years ago. New England flopped in its first season without Bill Belichick, and Vrabel was hired to tighten and toughen a soft team that was woefully outclassed in 2024.
The best matchup of Sunday afternoon is in the late window with the Green Bay Packers hosting the Detroit Lions. The Packers are the future market pick to best challenge the Lions for the NFC North title.
Sunday Night Football offers a potential AFC Championship Game preview when the Buffalo Bills host the Baltimore Ravens. NBC must be thrilled to get a matchup of Super Bowl favorites who are perennial playoff contenders. Quarterbacks Lamar Jackson of Baltimore and Josh Allen of the Bills could spark a shootout.
The first week ends with an outstanding Monday Night Football showdown of ancient rivals from the NFC North. The Chicago Bears will host the Minnesota Vikings in a matchup of teams who could go either way in 2025.
NFL Schedule
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