2025 NFL Week 1 Best Bets - Football Lines
The waiting is finally over with the 2025 NFL season set to open on Thursday, September 4 with a NFC East matchup between defending Super Bowl champion Philadelphia and Dallas. The Eagles won 14 games last year for the second time in three seasons reaching the Super Bowl on both occasions. The Eagles avenged a loss to Kansas City three years ago by blasting the Chiefs, 40-22, in February behind game MVP Jalen Hurts. En route to their second Super Bowl title the Eagles feasted on Dallas winning both regular season meetings by a combined score of 75-13.
The NFL heads to Brazil on Friday with another division matchup on the slate. Looking to rebound from a humbling loss to Philly in the Super Bowl, the Chiefs are eager to prove they still have a championship roster. They won 15 games and reached the Super Bowl for a third straight time a season ago, but failed to become the first team in NFL history to win three consecutive Super Bowls. They take a seven-game winning streak over the LA Chargers into their matchup. And intra division games highlight the Week 1 slate with eight matchups among division foes. The most compelling might be the Monday Night Football contest between Minnesota and Chicago. After coordinating Detroit’s prolific offense, Ben Johnson was hired by the Bears to transform the unit and show why the club drafted Caleb Williams No. 1 overall in 2024.
NFL Betting Lines
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2025 NFL Week 1 Betting Lines
*Odds as of Monday, September 1, 10:00 AM ET
Seven teams will have a new head coach at the start of the 2025 season with five of those men at the helm for the first time. Las Vegas and New England hired veteran coaches to run their programs and they hook up in Week 1. The carousel in Vegas continued with the hiring of Pete Carroll, who won more than 60 percent of his games and a Super Bowl during his 14 years with the Seahawks. Carroll even coached the Patriots for three seasons in the late 1990s never having a losing season. Former Titans coach Mike Vrabel is back with the team he starred with for eight seasons. The Pats opened as a 2.5-point home favorite.
Only one of the five other teams with a new coach is favored heading into Week 1. After a successful stint coordinating Tampa Bay’s offense, Liam Coen was hired by Jacksonville to resurrect the career of former No. 1 overall pick Trevor Lawrence. Due to injuries Lawrence played only 10 games in 2024 and the Jags went 4-13. Despite their record the Jags had a successful run at the betting window going 9-7-1 ATS. They opened laying 3.5 points to Carolina.
The first overall pick in the recent NFL draft will get a stiff test on opening day. Cam Ward takes the Tennessee Titans into a matchup with Denver facing a defense that allowed the third fewest points and ranked among the top 10 in total defense. After snapping an eight year playoff drought the Broncos have their sights set on bigger things in 2025.
There are some compelling matchups in Week 1, but the best of the bunch could be the Sunday Night Football showdown between AFC heavyweights Baltimore and Buffalo. It’s the only playoff rematch from a season ago, with Buffalo won 27-25 in the divisional round when the Ravens failed to convert a potential game tying 2-point conversion in the final minutes. The Bills are a slight 1.5-point home favorite with the total of 51.5 the highest on the Week 1 board. In the last five meetings the UNDER is 4-0-1.
2025 NFL Betting Schedule
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