Kansas City Chiefs Week 1 Best Bets - NFL Betting Lines

Kansas City Chiefs Week 1 Best Bets - NFL Betting Lines

The Kansas City Chiefs begin the 2025 NFL betting season with championship aspirations despite a humbling finish to 2024. Oddsmakers continue to back Kansas City, posting the Chiefs at +780 Super Bowl odds, +382 to win the AFC Championship, and -135 favorites on the AFC West betting line. Their NFL win total is set at 11.5 games, once again one of the highest in the league. BookMaker Sportsbook now offers Bitcoin deposits and withdrawals for Chiefs fans betting on the NFL using crypto.

Patrick Mahomes and Andy Reid remain the foundation of Kansas City’s dominance, but after falling short on the biggest stage, the Chiefs enter the season hungry to reestablish themselves as the NFL’s premier team.

Chiefs vs. Chargers Week 1 Betting Lines

Spread: Chiefs -3

Total: 45

Money Line: Chiefs -165, Chargers +144

Ready to Bet on the Chiefs?

Chiefs Kingdom, ready to reign and win big? Bet Kansas City Chiefs 2025 NFL odds at BookMaker—spread bets, totals, player props, and futures all season long.

* Trusted by sharp bettors for over 30 years

* Early odds, fast payouts, and Bitcoin betting

* Live betting and mobile-optimized sportsbook

* Don’t just watch the action — bet on it!

* Sign Up Now and lock in your Chiefs picks today!

Kansas City Chiefs Week 1 Matchup

On Friday, September 5, 2025, the Kansas City Chiefs will face the Los Angeles Chargers at Corinthians Arena in São Paulo, Brazil. Kickoff is scheduled for 8:00 p.m. ET with exclusive streaming coverage on YouTube. NFL betting odds opened with Kansas City as -2.5 favorites, and market movement has pushed the spread to -3 at heavier juice. The NFL total opened at 44 points and has ticked up to 45, reflecting expectations of offensive fireworks in the international spotlight.

The matchup offers a high-profile start to the NFL betting season. Kansas City has dominated the AFC West in recent years, but the Chargers have consistently played them tough. The Chiefs are 8–2 straight up in their last ten road games overall, but just 3–6–1 against the spread in their last ten meetings with the Chargers, with three of the last four staying below the total. Bettors weighing NFL Week 1 odds will have to decide whether Kansas City can cover as neutral field road chalk in a rivalry that often plays closer than expected.

Injuries provide an added wrinkle. Running back Kareem Hunt, corner Jaylen Watson, and linebacker Drue Tranquill are all listed as questionable. Each impacts depth at key positions, though Mahomes’ presence often offsets short-term concerns. Still, sharp bettors often factor injuries heavily when analyzing NFL point spreads, especially in early-season contests.

The international setting also adds intrigue to NFL betting markets. Neutral-site games can disrupt travel and preparation routines, occasionally leading to unpredictable results against the NFL spread. With the total inching higher, bookmakers anticipate that Mahomes and Justin Herbert will trade scores in a contest that should attract significant handle across NFL betting platforms.

Kansas City Chiefs 2024-25 Recap

The 2024 season was successful by most measures, but it ended in disappointment. Kansas City finished 15–2 straight up, 8–9 against the spread, and 7–10 to the Over/Under, securing another AFC West crown but falling short when it mattered most. Bettors who backed the Chiefs found mixed results: their dominance straight up rarely translated into consistent ATS wins, and Unders hit more often than not as the defense carried stretches of the year.

Still, there were notable breakout performers. Rookie wideout Xavier Worthy emerged as a dynamic deep threat, adding an explosive element to Kansas City’s passing attack and giving Mahomes a much-needed downfield option. On defense, cornerback Trent McDuffie elevated his game to Pro Bowl levels, consistently matching up against top receivers and allowing the Chiefs to dictate coverage schemes. These bust-out players ensured Kansas City remained balanced despite offensive lulls.

Mahomes continued to carry the offense, but inconsistency at receiver and a run game that lacked punch limited the team in high-leverage spots. The defense often masked those deficiencies, holding opponents in check and driving the Under trend in totals markets. Bettors targeting Kansas City totals last year found value fading expectations of shootouts, a shift from prior seasons when Overs were the default.

From a futures perspective, the Chiefs remained a constant presence near the top of NFL odds boards. Their inability to cover spreads regularly, however, left them as a tricky team to back week to week. Sharp money often faded Kansas City ATS, even as public bettors continued to pile on Mahomes-led lines.

Looking ahead, the Chiefs’ 11.5-win total underscores market belief in their staying power. With Mahomes still at the peak of his powers and Reid guiding the ship, Kansas City remains the benchmark for AFC contenders. Bust-out talent from 2024 combined with established stars keeps them formidable. NFL bettors will now watch closely to see if the Chiefs can not only dominate in the standings but also deliver more value against the number in 2025. Week 1 against the Chargers is the first test.

2025 Kansas City Chiefs Schedule, Results & Record

With the exception of trading Joe Thuney for salary-cap reasons, it's hard to find much to quibble with when it comes to Kansas City's offseason. The most questionable move was the splurge for Jaylon Moore in free agency, but the Chiefs followed it up by picking a player who might have been the first tackle off the board were it not for a knee injury.

Retaining Trey Smith via the tag was much needed, but actually getting him signed to a long-term extension would be even better. There are still question marks at the other guard spot, but the team should not be totally hamstrung by inept left tackle play this time around. Whenever that's been the case during Patrick Mahomes' career, things have worked out quite well in Kansas City.

Chiefs Past Seasons (2000)

The Kansas City Chiefs were founded in 1960 as the Dallas Texans and American Football League charter members. Owner Lamar Hunt was also the founder of the AFL. Shortly after Hunt formed the AFL and his franchise, the NFL counterattacked with a declaration of war. The Dallas Cowboys were created to fight the Texans in the Dallas and Fort Worth area. Following their 1962 AFL championship, the Texans were wooed to Kansas City, where they became profitable.

The Kansas City Chiefs were one of the greatest teams in NFL history from 1966 through 1971. They played in the first Super Bowl, losing to the Green Bay Packers. Kansas City then beat the Minnesota Vikings in Super Bowl IV. After that game, the AFL and NFL merged.

Those Chiefs teams were loaded with Hall of Famers such as coach Hank Stram, quarterback Len Dawson, kicker Jan Stenerud, linebackers Willie Lanier and Bobby Bell, defensive backs Johnny Robinson and Emmitt Thomas, and defensive linemen Buck Buchanan and Curley Culp. Players from that era often lament that more championships should have been won.

The Chiefs went into a dark period from 1974 through 1988 before new team president Carl Peterson and coach Marty Schottenheimer made them perennial contenders in the 1990s.

But it was not until Andy Reid arrived as head coach that the Chiefs returned to the Super Bowl and won it 50 years after their first title. Quarterback Patrick Mahomes surpassed Len Dawson as the best in franchise history.

The Chiefs are a proud legacy franchise. In fact, the AFC championship trophy is named after their late, great Hall of Fame founder, Lamar Hunt.

Did You Know?

At BookMaker, we go beyond just providing top-notch sports betting options! Take advantage of these exclusive features and rewards:

BookMaker ATM Card for seamless transactions: Easily access your funds with the BookMaker ATM card, providing instant access to your winnings and secure transactions wherever you go.

Loyalty Levels & BetPoints Programs for additional rewards: Earn BetPoints as you bet, and unlock exciting perks at higher loyalty levels. The more you play, the more you earn!

Seasonal and Reload Bonuses to maximize your earnings: Stay ahead with seasonal promotions and reload bonuses, boosting your bankroll throughout the year.

Early Cashout Option for added flexibility: Cash out your bet early and lock in profits or limit losses—putting you in control of your wagers.

Free Crypto Payouts for fast and secure withdrawals: Enjoy fast, secure withdrawals with zero fees when you choose crypto payouts.

Open Play Option for unique parlay betting: Get creative with your parlays using the Open Play option, offering more ways to win.

Casino Promotions & Contests for extra fun and wins: Join in on exclusive casino promotions and contests, adding excitement to your betting experience.

8% Cash Back on all your horse racing bets: Place horse racing bets and get 8% cash back on your losses, making it easier to bounce back.

Explore all these benefits and more at BookMaker!

Betting Rules & Policies

Free Play Rules

• Free plays cannot be used on proposition bets.
• Free Plays do not earn any BetPoints™
• Bets made using Free Plays do not count towards completing any rollovers. (Free Plays are always subject to a rollover of their own. You must complete the required rollover prior to making a withdrawal).
• The maximum payout for any Free Play is $5,000.
• Free Plays that are left unused for 180 days will be removed from your account.

ROLLOVER

• Did you know that on all deposits made at BookMaker, there is a rollover requirement: an amount of betting action you must fulfill before you are eligible to make a withdrawal.

• Did you know that rollovers are calculated by multiplying the amount initially credited to your account a certain number of times? Yes! If you deposit without claiming any bonus, the rollover will always be 1x (one-time) your deposit amount. If you do claim a deposit bonus, the rollover will be higher and is based on the deposit plus bonus amount.

Wager disputes (claims)

If you disagree with any aspect of a wager you’ve placed, you are welcome to log an official dispute (commonly known as a “claim”). Claims must be reported no later than 15 (fifteen) calendar days following the settlement of the wager.

If following an initial review of the case there remains any doubt regarding the wager type, line, market, amount, or any other detail, the claim will be escalated to the BookMaker management team. All decisions made by them are final.

Wager Cash Out - How it works

With the Cash Out feature you can choose to eliminate a wager that's already been placed, and receive back either a portion, or your full stake amount.

Cash Out is selectively available on certain events, fixtures, and markets.

In order to see if a wager is eligible to be cashed out, simply navigate to your Bet Slip and check the 'My Open Bets' tab. If eligible, the Cash Out button will be displayed.

It’s also important to note that Cash Out is not contributing to any bonus or promotion including Bet Point accumulation and Rollover for releasing bonus cash.