2025 NFL Week 4 Best Bets - Football Lines

2025 NFL Week 4 Best Bets - Football Lines

One team from six of the eight divisions remains unbeaten as we enter Week 4 of the NFL season. That number will drop by at least one when the Philadelphia Eagles and Tampa Bay Buccaneers square off on Sunday in a NFC tilt. The betting week starts on Thursday Night Football with one of three divisional matchups on the slate. The Arizona Cardinals suffered their first loss of the season in Week 3 and will look to rebound against the Seattle Seahawks. Both teams are 2-1 with their lone defeat to NFC West leading San Francisco.

There is a full day of NFL action on Sunday starting with the International Series contest between the Vikings and Steelers from Ireland. The game is set to kickoff at 9:30 a.m. ET. The Eagles/Bucs game is the marquee matchup in the early window on Sunday. Tampa Bay’s three wins have come in the closing moments by a total of six points. The Eagles have won nine in a row overall going 7-2 ATS. They opened as a 3.5-point road favorite. AFC powers Baltimore and Kansas City are both 1-2 heading into their Week 4 showdown. The Chiefs are a rare home underdog catching 2.5-points on the initial line and the total of 49.5 is the highest on the early Week 4 board. The betting week concludes with the second of four Monday Night Football doubleheaders.

NFL Betting Lines

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2025 NFL Week 4 Betting Lines

*Odds as of Tuesday, September 23, 10:00 AM ET

The Chiefs avoided a 0-3 start with a decisive 22-9 win over the Giants on Sunday night. The offense has been inconsistent all season not scoring more than 22 points in a game and averaging 315.7 yards. They have a chance to get well against a Baltimore unit that’s been shredded. One bad outing could be the guys having a bad night. But three makes the Ravens defense a liability. The unit allowed 426 yards to the Lions in Monday night’s 38-30 loss, including more than 200 yards on the ground.

The Ravens are last in total defense and next to last in points allowed. With Lamar Jackson leading an offense that averages 37 points, the Ravens are 3-0 against the OVER. The total of 49.5 is the highest on the early Week 4 board.

There are a few surprises among the six unbeaten teams. The Daniel Jones fiasco looks like another flop for the Giants. Jones has completed 71.6 percent of his passes for 816 yards and three TDs without being intercepted. The Colts are 3-0 for the first time since 2009 when they reached the Super Bowl. Indy faces a tough Rams defense on Sunday as a 3.5-point dog. Buffalo is a massive favorite to improve to 4-0. The Bills opened as 16-point chalk for Sunday’s game with the winless Saints.

And speaking of winless, two teams have a chance to exit that group with a pair of games featuring clubs looking for their first victory. The two-time defending AFC South champion Houston Texans have struggled offensively averaging a NFL low 12.7 points. The Titans haven’t been much better and both are in the cellar. It’s been a tough start for No. 1 overall pick Cam Ward, who is completing less than 55 percent of his passes. And Tennessee’s defense has allowed 74 points in the last two games. Still the total of 39.5 is the lowest on the early Week 4 betting line.

Another division will lose a member of the winless ranks when the Jets at Dolphins square off in one of two Monday Night Football games. Two of New York’s losses have come in the final seconds on opponent field goals. Tampa’s Chase McLaughlin matched Pittsburgh’s Chris Boswell from Week 1 by hitting a game-winning field goal to beat the Jets. Thought to be a strength New York’s defense has allowed an average of 31 points.

The Bengals got a glimpse of life without Joe Burrow and it wasn’t pretty. Cincy’s unbeaten start ended with a thud in Minnesota last week. Five turnovers, including two Jake Browning interceptions didn’t help. For the second straight week the Broncos lost on a late field goal, this time to the Chargers in an AFC West matchup. Denver opened as a 7-point home favorite to a team they’ve dropped two in a row to.

NFL Schedule

• Week 1
• Week 2
• Week 3
• Week 4
• Week 5
• Week 6
• Week 7
• Week 8
• Week 9
• Week 10
• Week 11
• Week 12
• Week 13
• Week 14
• Week 15
• Week 16
• Week 17
• Week 18

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