NFL Week 4 Betting Online
Week 4 opens with an Amazon Prime Thursday night matchup between the visiting Seattle Seahawks and the Arizona Cardinals. Seattle is coming off a surprisingly good 10-7 season under Mike Macdonald, a rookie head coach. Sam Darnold arrives from Minnesota, where he was the quarterback of a 14-3 team. Darnold figures to be an upgrade for the Seahawks. Arizona was 8-9 last year after going 4-13 in the 2023 campaign. Kyler Murray remains under center for the Cardinals, who showed marked improvement under Jonathan Gannon, who was also a rookie HC season. The NFC West looks like one of the most competitive divisions in football, which makes this game highly important.
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2025 NFL Week 4 Schedule
One of the most compelling games of the week comes in the early window when the Tampa Bay Buccaneers host the Philadelphia Eagles. Both teams are coming off playoff campaigns, with Philadelphia dominantly winning the Super Bowl.
Baker Mayfield arrived as a castoff quarterback and failed as the number one draft pick, but he has resurrected his career to become a credible starting quarterback. Mayfield has put the Buccaneers into the playoffs in both of his seasons under center.
Tampa Bay has the benefit of playing in the NFC South, which ranks as one of the worst divisions in the NFL. But the Buccaneers have been good enough to take advantage of the bad competition to become a regular playoff club.
There is not enough good to say about the Eagles, who may be even better for the 2025 season after a strong draft. Philadelphia has built the best organization in football, but repeating as Super Bowl champion is never easy.
In the late Sunday window, fans and gamblers are treated to a powerhouse matchup from the AFC: the Kansas City Chiefs will host the Baltimore Ravens. Baltimore and Kansas City have developed quite a rivalry through the years as regular top contenders.
The quarterback matchup of Lamar Jackson and Patrick Mahomes speaks for itself. So too does the coaching showdown of Baltimore’s John Harbaugh and Kansas City’s Andy Reid.
Lamar Jackson has to be tired of hearing that he is a multi-MVP award winner who cannot reach the Super Bowl. His matchup with Mahomes accentuates that reputation.
The Chiefs and Ravens could serve as a potential playoff preview, and it will surprise nobody if they clash in the AFC championship game.
The late Sunday afternoon window also features an interesting matchup of historic brands when the Las Vegas Raiders host the Chicago Bears. Ben Johnson is the rookie head coach of the Bears and was specifically hired to help Caleb Williams reach his quarterback potential as the first player taken in the 2024 NFL Draft. Johnson made his reputation as the offensive coordinator of the Detroit Lions, where he helped resurrect the career of Jared Goff.
Speaking of name-brand matchups, the Dallas Cowboys will host the Green Bay Packers on NBC Sunday Night Football. This matchup means TV ratings and a massive betting handle. Brian Schottenheimer was not a popular pick to replace Mike McCarthy as head coach of the Cowboys, but he can quiet his critics with a playoff season in 2025.
Matt LaFleur replaced McCarthy as head coach in Green Bay and has done a credible job. Green Bay upset McCarthy’s best Dallas team in the 2023 NFC playoffs in an unforgettable performance.
NFL Schedule
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