Since losing the NFC championship game in 2015, the Arizona Cardinals have had one winning season and playoff berth (2021). Head coach Jonathan Gannon is in his third season as head coach. Correlate that the Cardinals continue to improve under his leadership.
Following two wins to begin the season, the Cardinals played at San Francisco on Sunday. Arizona suffered a painful loss, halting its momentum.
Second year head coach Mike Macdonald and his Seattle Seahawks are off to a promising start as well. Now Seattle heads to the desert to take on the Cardinals Thursday night.
Explore the latest Week 4 NFL betting lines and predictions for Thursday Night Football.
NFL Betting Lines
Seattle Seahawks at Arizona Cardinals Odds at Bookmaker
State Farm Stadium in Glendale, AZ, is the venue for the Thursday, September 25, 2025, NFC West matchup between the Arizona Cardinals and Seattle Seahawks. Kickoff time is 8:15 p.m. ET with television coverage on Amazon Prime Video.
The Seattle Seahawks opened as 1.5-point road dogs, with the Arizona Cardinals 1.5-point home favorites.
The Seahawks and Cardinals opened with a total of 43.5.
Seattle is a +102 moneyline underdog with Arizona a -122 favorite.
Seattle Seahawks
Last week, the Seattle Seahawks beat the New Orleans Saints 44-13 as 7.5-point home favorites. The game went over the sportsbook total of 42.
Seattle is 2-1 straight up, 2-1 against the spread, and 2-1 over the total.
Seattle has NFL metrics of 18th for total offense, 5th for scoring offense, and 24th for fewest turnovers committed. In comparison, Seattle ranks 14th in total defense, 2nd in points allowed, and 2nd in takeaways.
Rookie Tory Horton scored two touchdowns, one on a franchise-record punt return, as the Seattle Seahawks trounced the visiting New Orleans Saints.
Kenneth Walker III rushed for a pair of short TDs for the Seahawks. Also, Sam Darnold completed 14 of 18 passes for 218 yards and two touchdowns.
Horton returned Kai Kroeger’s punt 95 yards for a score, besting the mark of 94 set by Charlie Rogers in 1999. And it was matched by Nate Burleson in 2007. It was the Seahawks' first TD on a punt return since Tyler Lockett accomplished the feat in his NFL debut in 2015.
Arizona Cardinals
Last week, the Seattle Seahawks beat the New Orleans Saints 44-13 as 7.5-point home favorites. The game went over the sportsbook total of 42.
Seattle is 2-1 straight up, 2-1 against the spread, and 2-1 over the total.
Seattle has NFL metrics of 18th for total offense, 5th for scoring offense, and 24th for fewest turnovers committed. In comparison, Seattle ranks 14th in total defense, 2nd in points allowed, and 2nd in takeaways.
Rookie Tory Horton scored two touchdowns, one on a franchise-record punt return, as the Seattle Seahawks trounced the visiting New Orleans Saints.
Kenneth Walker III rushed for a pair of short TDs for the Seahawks. Also, Sam Darnold completed 14 of 18 passes for 218 yards and two touchdowns.
Horton returned Kai Kroeger’s punt 95 yards for a score, besting the mark of 94 set by Charlie Rogers in 1999. And it was matched by Nate Burleson in 2007. It was the Seahawks' first TD on a punt return since Tyler Lockett accomplished the feat in his NFL debut in 2015.
Seahawks at Cardinals Betting Trends
Late on Seattle has been a good value on the road. The Seahawks got the cash in five of their most recent seven away games.
The Seahawks went over the total in four of their last five road matchups.
In like manner, the Cardinals have been a good value at home. Arizona covered the spread in five of its latest seven home games.
The Cardinals went over the total in five of their last eight home games.
In this series between the Seahawks and Cardinals, Seattle got the cash in six of the last seven meetings.
Four of the most recent six meetings between the Cardinals and Seahawks went under the total.
Specifically at Arizona, Seattle got the cash in three of its most recent four visits.
Four of the last five games between the Seahawks and Cardinals at Arizona went over the total.
Seahawks at Cardinals Best Bets
As was previously noted, Seattle brings good value on the road and against the Cardinals. Also, this is an over/under total for the entire series.
Main Pick: Seattle Seahawks
Over/Under Pick: Over the Total
Player Prop Picks: Kyler Murray Under the Passing Yards Total
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