2025 Thursday Night Football Best Bets - NFL Lines & Picks

2025 NFL Thursday Night Football Week 6 Betting Lines

For the fourth straight week and for the fifth time in six games the NFL betting week opens with a divisional matchup. The NFC East is featured in Week 6 of Thursday Night Football when the defending champion Philadelphia Eagles visit the New York Giants. Both teams are coming off losses with the Eagles having their 10-game overall winning streak stopped by Denver, 21-17. The Giants dropped to 1-4 with a 26-14 setback at previously winless New Orleans.

The Eagles got payout wins in both games last season with their defense holding the G-Men to 119 total yards in a 28-3 win in the Meadowlands. And Philly has had the better of the series recently winning seven of the last eight head-to-head encounters. The Eagles have also enjoyed plenty of success against division foes winning 13 of their last 16 games against the NFC East. However, all three of those defeats have come in the last five road games against their closest rivals with one of those to the Giants in the 2023 season finale. The early NFL betting line has Philadelphia as a 7.5-point favorite.

Eagles at Giants TNF Week 6 Lines

Spread: Eagles -7

Total: 40.5

Money Line: Eagles -377 / Giants +309

Eagles at Giants Betting Preview

Their run of good luck in close games ran out on the Eagles against Denver. Philly won each of its first four games by no more than seven points and trailed at some point in the first three. They came back from a 26-7 third quarter deficit to beat the Rams in Week 3 and nearly lost a big lead to Tampa Bay the following the game. Against the Broncos they couldn’t hold a 14-point advantage in the fourth quarter getting outscored 18-0 in the final frame for their first loss since before last Christmas.

Philadelphia’s offense has been sluggish at the start of the season averaging just 261.6 yards. And Saquon Barkley has yet to get on track rushing for more than 60 yards just once. Since going for a season-high 88 yards in a Week 2 win over Kansas City, Barkley is averaging less than 40 yards per game and 2.8 yards per carry. He carried the ball only six times against the Broncos compiling 30 yards. In his only game against the team that drafted him, Barkley ran for 176 yards and a TD in Philadelphia’s 28-3 win in Week 7 last season.

The defense has slipped a little as well giving up about 60 more yards and four points more per game than they did last season. The drop in production on both sides of the football can be masked when a team is winning. However, when the losses come, those numbers get scrutinized more heavily.

Switching QBs from Russell Wilson to Jaxson Dart paid dividends in Week 4 when the Giants upset the Chargers for their first win of the season. Dart threw a TD pass and scored on a 15-yard run, but the offense still lacked pop. The Giants had just 250 total yards and averaged 3.6 yards per play. One of their TDs was a 3-yard drive following an interception. Dart and the Giants got a taste of reality in Sunday’s loss to New Orleans. The rookie tossed two interceptions and was responsible for three of New York’s five turnovers. Dart will be the fourth different starting QB for the Giants to face the Eagles following Drew Lock, Daniel Jones and Tyrod Taylor.

No team is good enough to overcome five turnovers, even if it is against the Saints. And the Giants right now aren’t good enough. Those drive killers limited the offense and the Giants played below the closing total for the fourth time in five games. And the UNDER has been big in this series cashing in the last three meetings and in five of the last six.

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