2025 NFL Monday Night Football Week 12 Betting Lines
For the first time in several years the Carolina Panthers find themselves in a race for the division title. They will look to keep pace with Tampa Bay in the NFC South when they clash with the San Francisco 49ers in the Week 12 Monday Night Football matchup. The Panthers have won five of their last seven games and got a record-setting performance from Bryce Young in Sunday’s overtime win over Atlanta. The Panthers face a stiff test against a Niners group that is starting to get healthy.
Getting Brock Purdy back in the lineup was a boost for San Francisco’s offense, which scored a season high in Sunday’s 41-22 win over Arizona. But for the Niners to make up ground in the tough NFC West they’ll need to string wins together. Since starting the year 3-0 they’ve alternated wins and losses going 6-1-1 against the OVER in their last eight outings. The game at Levi’s Stadium in Santa Clara, CA kicks at 8:15 p.m. ET on November 24 and will air on ABC and ESPN.
Panthers at 49ers MNF Week 12 Lines
San Francisco 49ers -7
Total: 48
Moneyline: Panthers +254 / 49ers -301
Panthers at 49ers Betting Preview
What could prevent the Panthers from elevating even higher is their inconsistent play. Two weeks ago they lost to New Orleans at home, 17-7, with the offense generating just 175 total yards against a team that had just one victory entering the contest. Bryce Young was the target of criticism after throwing for 124 yards with an interception. Young bounced back in a big way on Sunday overcoming a trip to the locker room to address and ankle injury and throwing for a franchise record 448 yards in the 30-27 overtime win over the Falcons.
Offense has been a struggle all season. The Panthers have scored 16 points or less six times yet somehow managed to win two of those games. Young has completed 62.7 percent of his passes for 1,962 yards and 14 TD’s with seven interceptions. They are averaging 18.8 points and 5.0 yards per play, which are both less than what they accomplished last season. But here they are at 6-5 already with more wins than they had last season and one victory away from matching the most in any of the previous seven campaigns.
A good chunk of Panthers success can be attributed to their defense, which has improved dramatically from a season ago when the group was dead last in both yards and points allowed. The Panthers find themselves with the 12th best scoring defense while surrendering an average of almost 80 yards less per game. And they’ve been more profitable at the betting window with payouts in seven of their last 10 games.
It helped that the Niners played a bad Arizona club making the return of Brock Purdy a success. Perhaps seeing how well Mac Jones played in his absence was an inspiration. Playing for the first time in nearly two months, Purdy showed no signs of rust hitting on 19 of 26 for 200 yards and three TDs as the Niners scored a season-high in the 41-22 triumph.
For the first time Christian McCaffrey will face the team that drafted him and he’ll do so as the NFL leader in scrimmage yards. McCaffrey rushed for 81 yards and two scores with 40 receiving yards and a TD against the Cardinals. For the season he has more than 700 yards in each category and his 11 total TDs are tied for the second most.
However, playing without key defenders Nick Bosa, Fred Warner and Mykel Williams keeps things interesting. The Rams tallied 42 points against the group in Week 10 and the Niners are 15th in the NFL allowing 23 points an outing allowing them to cash the OVER in three straight games and in six of the last eight with a push on the total.
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2025 Monday Night Football Betting Schedule
| WEEK |
VISITING TEAM |
HOST TEAM |
SCORE |
| Week 1 |
Minnesota Vikings |
Chicago Bears |
27-24 |
| Week 2 |
Tampa Bay Buccaneers |
Houston Texans |
20-19 |
| Week 2 |
Los Angeles Chargers |
Las Vegas Raiders |
20-9 |
| Week 3 |
Detroit Lions |
Baltimore Ravens |
38-30 |
| Week 4 |
New York Jets |
Miami Dolphins |
21-27 |
| Week 4 |
Cincinnati Bengals |
Denver Broncos |
3-28 |
| Week 5 |
Kansas City Chiefs |
Jacksonville Jaguars |
28-31 |
| Week 6 |
Buffalo Bills |
Atlanta Falcons |
14-24 |
| Week 6 |
Chicago Bears |
Washington Commanders |
25-24 |
| Week 7 |
Tampa Bay Buccaneers |
Detroit Lions |
9-24 |
| Week 7 |
Houston Texans |
Seattle Seahawks |
19-27 |
| Week 8 |
Washington Commanders |
Kansas City Chiefs |
7-28 |
| Week 9 |
Arizona Cardinals |
Dallas Cowboys |
27-17 |
| Week 10 |
Philadelphia Eagles |
Green Bay Packers |
10-7 |
| Week 11 |
Dallas Cowboys |
Las Vegas Raiders |
33-16 |
| Week 12 |
Carolina Panthers |
San Francisco 49ers |
- |
| Week 13 |
New York Giants |
New England Patriots |
- |
| Week 14 |
Philadelphia Eagles |
Los Angeles Chargers |
- |
| Week 15 |
Miami Dolphins |
Pittsburgh Steelers |
- |
| Week 16 |
San Francisco 49ers |
Indianapolis Colts |
- |
| Week 17 |
Los Angeles Rams |
Atlanta Falcons |
- |
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