2025 Monday Night Football Best Bets - NFL Lines & Picks

2025 NFL Monday Night Football Week 10 Betting Lines

A showdown between NFC heavyweights takes place on Monday Night Football to close Week 10 of the NFL season. The defending Super Bowl champion Philadelphia Eagles come off their bye week to visit the Green Bay Packers at historic Lambeau Field. At 6-2 the Eagles are tied with three other teams for the best record in the conference. Philly entered its off week with two straight wins behind a resurgent offense led by Jalen Hurts, who had seven TD passes in wins over the Giants and Vikings.

The Packers had a chance on Sunday to claim the best record in the NFC. However, they were stunned at home losing to Carolina 16-13 as a 13.5-point favorite. They also lost earlier in the season to a bad Cleveland team. Many consider the Packers to be a legitimate threat in the NFC, but questions will remain with losses to teams they should beat. Green Bay opened as a 2.5-point favorite to end a 3-game losing to the Eagles. The game kicks at 8:15 p.m. ET on November 10 and will air on ABC and ESPN.

Eagles at Packers MNF Week 10 Lines

Spread: Packers -2.5

Total: 45.5

Money Line: Eagles +117 / Packers -135

Eagles at Packers Betting Preview

I’m not sure if the bye came at a good time or a bad time for the Eagles. They were playing their best football of the season leading up to the off week with a road win over Minnesota and a payback victory over the Giants getting payouts as the betting favorite in each. Over that stretch they scored 66 points with a suspect passing game fueling the surge. In their two previous games, losses to the Giants and Denver, the Eagles scored 17 points in each.

The Eagles won the Super Bowl last season behind a relentless defense that led the NFL allowing the fewest yards and second fewest points. The group hasn’t been as dominant this year but the Eagles have the same record through eight games. And their standing as the top team in the NFC East got a boost when every other team in the division lost in Week 9 with each now having a multi-game skid.

We saw a lot of what led to Philly’s Super Bowl run a season ago in their most recent game. Just two weeks after a humiliating Thursday Night Football loss to the Giants, the Eagles avenged that setback with a convincing 38-20 triumph. Saquon Barkley haunted his old team rushing for 150 yards and a TD on 14 carries. Hurts had four scoring passes and the defense held the G-Men to 246 yards and recorded five sacks. The Eagles now have payouts in two straight and five of their last seven games.

It’s been hard to get a grip on the Packers this season. At times they look like the best team in the NFC with the defense holding Detroit, Washington and Cincinnati to fewer than 20 points in wins. Jordan Love was on fire throwing for 360 yards and three TDs to beat the Steelers in Week 8. But the games they didn’t win are concerning. The Pack scored a total of 23 in losses to Cleveland and Carolina with Love getting picked off once in each game. He’s thrown just three interceptions the entire season.

Boosted by the acquisition of Micah Parsons before the season started, the Packers have a top 10 defense allowing 286.4 yards and 20.8 points per game. However, in Week 4 against Dallas the stop group allowed 436 yards and a season-high point total in the 40-40 tie. It might be a good thing that the Packers are only a 2.5-point opening favorite. In their last five games when laying at least 6.5 points Green Bay is 0-5 ATS with two outright losses.

Last season started and ended with a loss to Philadelphia extending Green Bay’s skid in the series to three straight games. The Packers have won two of the last three meetings in Green Bay, though, with the OVER hitting twice.

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2025 Monday Night Football Betting Schedule

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