2025 Monday Night Football Best Bets - NFL Lines & Picks

2025 NFL Monday Night Football Week 6 Betting Lines

The third of four Monday Night Football doubleheaders takes place in Week 6 of the NFL season. Playing as an 8-point home favorite the Buffalo Bills were upset 23-20 by AFC East rival New England on Sunday suffering their first loss of the season. They head to Georgia to battle the Atlanta Falcons in rare interconference tilt. This will be just the 14th meeting between the clubs. The Falcons are 2-2 coming off a bye. They entered the off week on the heels of a 34-27 upset win over Washington. Buffalo opened as a 3.5-point favorite with the total at 48.5.

The second game kicks off an hour later at 8:15 p.m. ET and features NFC hopefuls the Chicago Bears and Washington Commanders. The team formerly known as the Redskins rebounded from their loss to Atlanta by upsetting the Chargers on the road last week sparked by the return of Jayden Daniels, who missed the previous two games due to an injury. The Bears are coming off their bye after evening their record at 2-2 with back-to-back wins. The Bears have scored more than 20 points in every game after averaging just 18.2 points a season ago. The early total of 50.5 is tied for the highest on the Week 6 board.

Bills at Falcons MNF Week 6 Lines

Spread: Bills -4

Total: 49

Money Line: Bills -218 / Falcons +186

Bills at Falcons Betting Preview

The Bills were the last unbeaten team falling to New England on Sunday night after the Eagles had lost earlier in the day. And more concerning is that the Bills are suddenly jammed with several other teams atop the AFC standings and just a game ahead of the Patriots in the division Teams have bad games, the good ones don’t let them manifest into something bigger. For the first time this season the Bills scored fewer than 30 points. After turning the ball over just once in their first four games they had three turnovers against the Pats, including the first interception of the year for Josh Allen. The Bills have a more manageable spread this week as a 3.5-point early line favorite. They spotted New England 8-point and were favored by double digits in their previous two contests. The Bills failed to cover the line in all three games. They are, however, 3-0 SU and ATS in their last three games following a loss.

Just how perplexing can the game of football be? After getting shutout 30-0 by Carolina in Week 3 in a game Michael Penix Jr. was benched, the Falcons, and Penix, more than made up for it and entered their bye on a positive note. Penix rebounded throwing for 313 yards and two TDs and the Falcons beat Washington, 34-27, compiling their most yards (435) and points in a game this season. For the first time in four games the Falcons played OVER the closing total. They have cashed the OVER just four times in their last 13 games, though. The falcons are 2-3 SU and 3-2 ATS following they’re bye over the last five seasons.

Bears at Commanders MNF Week 6 Lines

Spread: Commanders -4

Total: 50.5

Money Line: Bears +190 / Commanders -223

Bears at Commanders Betting Preview

When the teams met in Week 7 last season it started a downward spiral for the Bears that led to their sixth straight non-winning season and another coaching change. Coming off their bye with a record of 4-2, the Bears gave up a last second Hail Mary that allowed Washington to escape with an 18-15 win. It also started a 10-game losing streak. Chicago enters this matchup on a 2-game heater with payout wins over Dallas and Las Vegas before the bye. Hiring Ben Johnson looks like the right move with his background leading to a resurgent Bears offense. They’ve scored more than 20 points in every game and rank 11th in the NFL with an average of 25.3 points, more than a converted TD better than what they averaged all last season. Caleb Williams has eight TD passes and more importantly has been sacked only seven times. Williams was sacked a NFL-high 68 times a season ago.

Washington isn’t sneaking up on anyone like they did last year and injuries played a role in their 3-2 starts. Jayden Daniels missed two games with a knee injury and the club went 1-1 with veteran Marcus Mariota behind center. The offense, though, revolves around Daniels and his ability to create and make plays. He was 15 of 26 for 231 yards and a TD last week overcoming a 10-0 deficit to beat the Chargers 27-10. The defense played a major role in the outcome forcing a pair of turnovers and recording five sacks, two by Dorance Armstrong. The teams have split the last four meetings with Washington’s wins by a combined eight points and the Bears winning twice by a margin of 36 points.

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2025 Monday Night Football Betting Schedule

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