Carolina Panthers Week 1 Best Bets - NFL Betting Lines
The Carolina Panthers enter the 2025 NFL betting season looking to turn the page after another rebuilding year under head coach Dave Canales. Carolina finished 5–12 straight-up in 2024, though they were a far better bet against the number at 8–9 ATS. Where bettors really cashed was on totals, as the Panthers led the NFL with a 13–4 mark to the Over. Their defense often wore down in second halves, while a young offense flashed but failed to sustain drives.
Oddsmakers remain skeptical, slotting the Panthers at 175-1 to win the Super Bowl after opening 150-1. Their NFC odds lengthened from 80-1 to 92-1, while their divisional price ballooned from 16-1 to 19-1 in a competitive NFC South. The bright side: Canales now has a year of groundwork installed, quarterback Bryce Young has another offseason under his belt, and Carolina added reinforcements on both sides of the line. For anyone in Carolina eyeing a bet, BookMaker Sportsbook now offers Bitcoin deposits and withdrawals for Panthers fans betting on the NFL using crypto.
Jaguars vs. Panthers Week 1 Betting Lines
Spread: Jaguars -3
Total: 46
Money Line: Jaguars -162, Panthers +142
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Carolina Panthers Week 1 Matchup
On Sunday, September 7, 2025, the Carolina Panthers will visit the Jacksonville Jaguars at EverBank Stadium in Jacksonville, Florida. Kickoff is set for 1:00 p.m. ET with television coverage on FOX. The line has tilted toward the visitors, with Jacksonville opening as a short favorite and holding at –2.5. The total opened 45.5 and has nudged to 46, reflecting expectations of offensive production for both sides. For Carolina, this is an early litmus test against an AFC playoff hopeful with a new coaching staff, and it will reveal how much progress the franchise has made since bringing up the rear of the NFC South a year ago.
The Panthers’ storyline entering Week 1 is growth. Young showed more command late in the 2024 season, connecting frequently with wide receivers Adam Thielen and Xavier Legette, while new addition Tetairoa McMillan brings vertical juice. Running back Chuba Hubbard should lead the backfield rotation, but Rico Dowdle is also expected to lend a helping hand. Against Jacksonville’s front, anchored by Arik Armstead and Travon Walker, Carolina’s offensive line will be the X-factor. Ikem Ekwonu and Austin Corbett must keep Young clean, especially on third-and-medium where the Panthers struggled mightily last fall.
Defensively, Carolina needs answers. The unit allowed over 31 points per game last season and was gashed on the ground far too often. Derrick Brown is a stalwart inside, but the pass rush lacked finishing ability in 2024. Still stinging from the departure of Brian Burns, free agent pickups Bobby Brown III and Patrick Jones II will try to pick up the slack. Against Trevor Lawrence and an offense featuring Brian Thomas Jr. and reigning Heisman Trophy winner Travis Hunter, Carolina will need to disguise coverage and generate pressure without overcommitting blitzers.
Special teams could swing this game, but field position will matter against a Jaguars team that thrives on short fields. Carolina’s return game, a weakness in 2024, has been emphasized this summer with Legette expected to factor as a spark. Trends don’t suggest much of a fight: Carolina is 2-8 SU and 3-7 ATS its last 10 on the road, but points could be had with the over paying out in six of those matchups. With the total trending higher, the Panthers will need red-zone touchdowns rather than field goals to stay competitive.
Carolina Panthers 2024-25 Recap
Carolina’s 5–12 record in 2024 was another reminder of the franchise’s rebuilding reality, though bettors who backed totals thrived. The Panthers were one of the NFL’s most reliable over teams, finishing 13–4 O/U thanks to a defense that leaked yards and an offense that gradually found rhythm. Against the spread, an 8–9 mark reflected competitiveness, but the team rarely translated close games into victories.
Bryce Young’s sophomore season was uneven but encouraging. He threw for over 2,400 yards with improved decision-making and better chemistry with his young wideouts. Hubbard emerged as a steadying presence in the run game, while Legette led the team in receptions and Thielen in yardage. Defensively, Brown stood out on the interior, but the lack of edge pressure left the secondary exposed, and opponents capitalized late in games.
The front office responded by investing in both trenches and adding playmaking depth. The Panthers know patience is required, but optimism exists around a young core that could take meaningful strides in 2025. Week 1 against Jacksonville offers an immediate opportunity to show fans — and NFL bettors — the lessons learned last year should translate into a sharper, more resilient group in 2025.
2025 Carolina Panthers Schedule, Results & Record
The Panthers could be a sleeper playoff team with all the notable moves they made on defense. Carolina desperately needed help after allowing a league-worst 179.8 rushing yards per game. It should be better in that area with a healthy Derrick Brown and Tershawn Wharton. The Panthers also gained depth on the edges, but they’re going to need immediate contributions from rookies Scourton and Umanmielen.
Carolina took advantage of a deep crop of edge rushers in the draft, bypassing defense in the first round to give Bryce Young a new weapon in No. 8 selection Tetairoa McMillan. After a rocky rookie year and a somewhat promising second season, this could be a make-or-break season for Young, who is now set for success with a stout offensive line, productive ground game, and an intriguing group of pass catchers.
It would have been on-brand for this team to pass on wide receivers in this class, claiming they'll rely on the development of Xavier Legette and Jalen Coker. That would have been another big mistake, and Panthers fans should breathe a sigh of relief that they went another direction. By picking the number one pure wide receiver prospect in this class, they made a huge investment at a premium position that was also one of their biggest roster holes. McMillan also happens to fit exactly what they're missing on the field with the current receiver corps. No draftee is a sure thing, but it would come as a surprise if McMillan can't develop into a solid long-term starter at the least.
Carolina Panthers Past Seasons (2000)
| YEAR |
RECORD |
PLAYOFFS |
| 2024 |
5-12 |
None |
| 2023 |
2-15 |
None |
| 2022 |
7-10 |
None |
| 2021 |
5-12 |
None |
| 2020 |
5-11 |
None |
| 2019 |
5-11 |
None |
| 2018 |
7-9 |
None |
| 2017 |
11-5 |
Lost Wild Card Round |
| 2016 |
6-10 |
None |
| 2015 |
15-1 |
Lost Super Bowl |
| 2014 |
7-8-1 |
Lost Divisional Round |
| 2013 |
12-4 |
Lost Divisional Round |
| 2012 |
7-9 |
None |
| 2011 |
6-10 |
None |
| 2010 |
2-14 |
None |
| 2009 |
8-8 |
None |
| 2008 |
12-4 |
Lost Divisional Round |
| 2007 |
7-9 |
None |
| 2006 |
8-8 |
None |
| 2005 |
11-5 |
Lost Conference Championship |
| 2004 |
7-9 |
None |
| 2003 |
11-5 |
Lost Super Bowl |
| 2002 |
7-9 |
None |
| 2001 |
1-15 |
None |
| 2000 |
7-9 |
None |
Carolina won the NFC championship in 2003 and 2015 but failed to win the Super Bowl. The Panthers were born as a 1995 expansion team. Ron Rivera led Carolina to four playoff berths from 2013 through 2017. Cam Newton won the 2015 NFL MVP honors as the Panthers' quarterback.
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