Arizona Cardinals 2025 NFL Betting Odds & Picks
The Arizona Cardinals continue to be a franchise that can’t get out of its own way. Since making the NFC championship game in 2015, Arizona has only one playoff appearance (2021). However, last year showed enough improvement to where fans and gamblers can reasonably hope that better days are ahead. Following a 4-13 rookie season, head coach Jonathan Gannon led the Cardinals to an improved mark of 8-9 in 2024. Quarterback Kyler Murray continues to improve under Gannon and is coming off his best season since 2021. Gannon has the Cardinals thinking playoffs, but the challenge will be to navigate the tough NFC West.
NFL Betting Lines
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2025 Arizona Cardinals Schedule, Results & Record
The Cardinals could have a top-10 defense this season thanks to Josh Sweat's splash signing. Sweat reunited with former Philadelphia Eagles defensive coordinator and Cardinals coach Jonathan Gannon.
Walter Nolen is a boom-or-bust defensive tackle, but he’ll get the benefit of leaning on veterans Calais Campbell and Dalvin Tomlinson. Suddenly, the Cardinals have depth and talent on a defensive front that desperately needed help since Gannon arrived in 2023. The secondary could also be much improved if Johnson is healthy and makes teams regret his surprising fall into the second round. The Cardinals rightfully prioritized their defense, but they might have settled for an offense that faltered after a 6–4 start last season.
After months of speculation, the Cardinals spent their first-round pick on Walter Nolen III. The All-American defensive tackle was a stud for Ole Miss, finishing 2024 with 6.5 sacks and 14 tackles for loss. While the Cardinals heavily invested in the position during free agency, they added youth to the rotation with Nolen. It's the second consecutive season that the Cardinals used a first-round pick on a defensive lineman.
Arguably the steal of the draft, Will Johnson slid into the second round after concerns about his injury history. Before his health was brought up, Johnson was projected as a surefire first-round talent. The Cardinals add Johnson to a room where he'll instantly compete for a starting role.
Arizona Cardinals Past Seasons (2000)
| YEAR |
RECORD |
PLAYOFFS |
| 2024 |
8-9 |
None |
| 2023 |
4-13 |
None |
| 2022 |
4-13 |
None |
| 2021 |
11-6 |
Lost Wild Card Round |
| 2020 |
8-8 |
None |
| 2019 |
5-10-1 |
None |
| 2018 |
3-13 |
None |
| 2017 |
8-8 |
None |
| 2016 |
7-8-1 |
None |
| 2015 |
13-3 |
Lost Conference Championship |
| 2014 |
11-5 |
Lost Wild Card Round |
| 2013 |
10-6 |
None |
| 2012 |
5-11 |
None |
| 2011 |
8-8 |
None |
| 2010 |
5-11 |
None |
| 2009 |
10-6 |
Lost Divisional Round |
| 2008 |
9-7 |
Lost Super Bowl |
| 2007 |
8-8 |
None |
| 2006 |
5-11 |
None |
| 2005 |
5-11 |
None |
| 2004 |
6-10 |
None |
| 2003 |
4-12 |
None |
| 2002 |
5-11 |
None |
| 2001 |
7-9 |
None |
| 2000 |
3-13 |
None |
Founded in 1920 as the Chicago Cardinals, the Arizona Cardinals have a long and winding history that includes much frustration and futility.
While in Chicago, the Cardinals operated in the shadow of the Chicago Bears. Before moving to St. Louis in 1960, the Cardinals had won only two championships, and they lost most of their seasons.
St. Louis immediately took to the Cardinals, but the losing continued. During their time in St. Louis, the Cardinals made the playoffs only three times. After failing to agree to a new stadium, the franchise moved to Arizona in 1988.
The Cardinals have had their greatest era of success in Arizona, although it is relatively modest compared to the better NFL franchises. The Cardinals have made the playoffs six times since 1998. The 2008 Cardinals made the franchise’s only Super Bowl appearance, losing to the Pittsburgh Steelers.
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