Arizona Cardinals Week 1 Best Bets - NFL Betting Lines

Arizona Cardinals Week 1 Best Bets - NFL Betting Lines

The Arizona Cardinals begin the 2025 NFL betting season with expectations of improvement in Year 3 of the Jonathan Gannon era. After an 8–9 finish in 2024, Arizona showed flashes of growth, particularly against the spread where they rewarded bettors with an 11–6 record versus the closing number. The franchise still has a long way to go in the NFC West, but with a healthier roster and a more established core, optimism has returned to the desert.

Oddsmakers remain skeptical of Arizona’s ceiling, listing them +7065 to win the Super Bowl after hitting the board 55-1. Their conference odds have moved from +3000 to +3039 since opening, while their odds of winning the NFC West drifted from +700 to +805. Those numbers suggest the betting market expects a mid-tier season at best, though the Cardinals believe their roster upgrades can push them beyond modest expectations. Kyler Murray is fully healthy, Marvin Harrison Jr. is entering his second season as a more-polished WR1, and veteran additions like Josh Sweat should finally give the pass rush some teeth. For fans looking to back Arizona, BookMaker Sportsbook now offers Bitcoin deposits and withdrawals for Cardinals fans betting on the NFL using crypto.

Saints vs. Cardinals Week 1 Betting Lines

Spread: Cardinals -6

Total: 42.5

Money Line: Cardinals -270, Saints +222

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Arizona Cardinals Week 1 Matchup

On Sunday, September 7, 2025, the Arizona Cardinals will visit the New Orleans Saints at the Caesars Superdome in New Orleans, Louisiana. Kickoff is set for 1:00 p.m. ET with coverage on FOX. The betting market has already moved sharply in Arizona’s favor. The Cardinals opened 2-point road favorites, but early action quickly pushed the NFL spread to –6, making them one of the most notable movers on the Week 1 board. This represents a strong vote of confidence in Murray, Harrison, and the additions to the defense, particularly given Arizona’s recent struggles as road favorites.

Historically, Arizona has not fared well as road chalk, dropping their last four matchups both straight-up and against the spread. More broadly, the Cardinals are just 3–7 straight-up in their last 10 road games, though they did cover six of those contests. This suggests that while outright victories have been hard to come by, bettors backing the Cardinals as underdogs have often walked away with winning tickets.

The storyline heading into Week 1 centers on whether Murray can find rhythm with Harrison against a Saints defense that remains aggressive up front. Arizona will look to use tempo and short passes to neutralize the pass rush, with James Conner expected to shoulder the early running load. The offensive line, anchored by Paris Johnson Jr. and Jonah Williams, has been inconsistent in the past, but continuity should give Murray the time he needs to create plays outside the pocket.

Defensively, Arizona needs to generate pressure. The addition of Josh Sweat was one of the off-season’s most important moves, aimed at fixing a pass rush that ranked near the bottom of the league in sacks last season. The Cardinals enter Week 1 short-handed with BJ Ojulari on the PUP list and cornerback Sean Murphy-Bunting on NFI-R. That means veteran Budda Baker will need to cover for those absences, both in terms of leadership and production. Baker, coming off a sixth straight Pro Bowl season, is the glue of the secondary and will be asked to set the tone immediately.

Jonathan Gannon has stressed discipline and situational awareness throughout training camp, particularly in hostile environments like the Superdome. Avoiding turnovers, staying ahead of the chains, and creating one or two defensive momentum plays are the keys for Arizona to walk out of Week 1 with a statement win that sets the team up for success moving forward.

Arizona Cardinals 2024-25 Recap

Arizona closed the 2024 season with an 8–9 record against the NFL betting odds, finishing third in the NFC West. While the record was disappointing, the Cardinals were one of the NFL’s best betting teams, finishing 11–6 ATS. That strong performance was a product of resilience, as Arizona often stayed within striking distance of superior opponents. Their totals results landed nearly even at 8–7–2 O/U, reflecting a team capable of both low-scoring defensive games and higher-paced offensive battles.

The Cardinals’ biggest issue last season was inconsistency on both lines. The offensive front gave up too much pressure, and the defense failed to create enough of its own. Despite those issues, Murray’s late-season form and connection with Trey McBride as a reliable option gives the franchise confidence entering 2025. Offseason moves targeted these weaknesses directly, with Sweat’s arrival and a renewed emphasis on depth in the trenches – including Calais Campbell’s return to the desert.

Gannon’s first two years were about evaluation and building a foundation. Year 3 must be about results. Arizona believes it has the right mix of youth and veterans to take a step forward. Week 1 in New Orleans will be the first chance to show that belief is more than just talk.

2025 Arizona Cardinals Schedule, Results & Record

The Cardinals could have a top-10 defense this season thanks to Josh Sweat's splash signing. Sweat reunited with former Philadelphia Eagles defensive coordinator and Cardinals coach Jonathan Gannon.

Walter Nolen is a boom-or-bust defensive tackle, but he’ll get the benefit of leaning on veterans Calais Campbell and Dalvin Tomlinson. Suddenly, the Cardinals have depth and talent on a defensive front that desperately needed help since Gannon arrived in 2023. The secondary could also be much improved if Johnson is healthy and makes teams regret his surprising fall into the second round. The Cardinals rightfully prioritized their defense, but they might have settled for an offense that faltered after a 6–4 start last season.

After months of speculation, the Cardinals spent their first-round pick on Walter Nolen III. The All-American defensive tackle was a stud for Ole Miss, finishing 2024 with 6.5 sacks and 14 tackles for loss. While the Cardinals heavily invested in the position during free agency, they added youth to the rotation with Nolen. It's the second consecutive season that the Cardinals used a first-round pick on a defensive lineman.

Arguably the steal of the draft, Will Johnson slid into the second round after concerns about his injury history. Before his health was brought up, Johnson was projected as a surefire first-round talent. The Cardinals add Johnson to a room where he'll instantly compete for a starting role.

Arizona Cardinals Past Seasons (2000)

Founded in 1920 as the Chicago Cardinals, the Arizona Cardinals have a long and winding history that includes much frustration and futility.

While in Chicago, the Cardinals operated in the shadow of the Chicago Bears. Before moving to St. Louis in 1960, the Cardinals had won only two championships, and they lost most of their seasons.

St. Louis immediately took to the Cardinals, but the losing continued. During their time in St. Louis, the Cardinals made the playoffs only three times. After failing to agree to a new stadium, the franchise moved to Arizona in 1988.

The Cardinals have had their greatest era of success in Arizona, although it is relatively modest compared to the better NFL franchises. The Cardinals have made the playoffs six times since 1998. The 2008 Cardinals made the franchise’s only Super Bowl appearance, losing to the Pittsburgh Steelers.

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