Buffalo Bills Week 1 Best Bets - NFL Betting Lines
The Buffalo Bills open the 2025 NFL betting season with expectations befitting a team that finished 13–4 straight-up in 2024, earned the No. 2 seed in the AFC, and pushed deep into January. Bettors who backed Buffalo also fared well: the Bills went 12–8 against the spread in all, while totals finished 12–6–2 to the Over, a profile that reflects an explosive offense led by Josh Allen and a defense that created timely stops in high-leverage spots. The mission now is simple: win a Super Bowl.
Allen remains the centerpiece of Buffalo’s championship hopes. His 2024 season showcased why he continues to be a perennial MVP candidate, pairing elite passing numbers with his trademark rushing ability. The defense, anchored by veterans in the secondary and a deep rotation up front, showed flashes of dominance but also struggled at times against explosive passing games. Oddsmakers respect Buffalo’s ceiling, opening them at +700 to win the Super Bowl before tightening to +611. The Bills’ AFC price shortened from +375 to +301, while their AFC East odds moved from –115 to –155. Their win total sits at 11.5, reinforcing expectations of another double-digit victory season. For fans ready to get behind Buffalo, BookMaker Sportsbook now allows deposits and withdrawals in Bitcoin, making it easier than ever for Bills fans betting on the NFL using crypto.
Bills vs. Ravens Week 1 Betting Lines
Spread: Bills -1
Total: 52
Money Line: Bills -118, Ravens -102
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Buffalo Bills Week 1 Matchup
On Sunday, September 7, 2025, the Buffalo Bills will host the Baltimore Ravens at Highmark Stadium in Orchard Park, New York. Kickoff for Sunday Night Football is scheduled for 8:20 p.m. ET with coverage on NBC. The number sits tight in a razor-thin market: Buffalo is –1, while the total opened 53.5 and has dipped to 52.5. The spotlight is obvious: a rematch of last season’s 27–25 playoff thriller, headlined by reigning MVP Josh Allen against Lamar Jackson. Edges will come down to situational football, red-zone execution, and who controls the “middle eight” around halftime.
For Buffalo’s offense, balance is the mission. Dalton Kincaid’s route inventory gives Allen a high-percentage valve on early downs, Keon Coleman’s size stretches the boundary, and Khalil Shakir, listed as questionable, threatens underneath and on crossers if active. James Cook supplies run-game stability and screen value, which helps slow Baltimore’s simulated pressures. The line must keep interior pockets clean so Allen can win from the spot; when structure breaks, his scramble-drill rapport with Kincaid and Coleman becomes the counterpunch.
Defensively, the Bills will crowd first down to blunt Derrick Henry between the tackles, then set firm edges to keep Jackson contained on keepers and second-reaction throws. Gregory Rousseau and the interior rush must compress launch points without losing rush lanes; that forces Baltimore into third-and-medium, where disguise and late rotation can steal a snap. The secondary, led by Taron Johnson, will pass off Zay Flowers in space and squeeze windows to Mark Andrews and Isaiah Likely, who is also listed as questionable. Field position matters in a one-point spread; Tyler Bass’ status bears watching given his listing as questionable.
Trends favor the home team with Buffalo 10–0 straight-up and 6–4 against the NFL spread in its last ten at Highmark Stadium, with the Over 7–3 across that span. If the Bills win early downs on defense, protect the pocket on third down, and finish drives with six instead of three, they put the opener on their terms.
Buffalo Bills 2024-25 Recap
The Bills’ 2024 campaign ended in familiar territory: dominant regular-season play followed by playoff disappointment. Their 13–4 record was enough to secure the No. 2 seed, and they looked like one of the AFC’s most complete teams entering January. Josh Allen’s ability to take over games was once again on full display, while Shakir and Kincaid provided consistent playmaking options. Defensively, Buffalo ranked near the top of the league in takeaways, though injuries late in the season exposed some depth concerns.
Buffalo’s 10–7 mark against the spread reflected a team that, while heavily favored most weeks, still managed to cover the NFL odds more often than not. Totals bettors found even more success, as the Bills’ 11–5–1 O/U regular season record highlighted their ability to light up the scoreboard and push opponents into high-tempo contests. Still, the season ended in frustration as Buffalo fell short in the AFC playoffs, leaving fans to wonder if this year will finally be different.
The front office resisted major changes, instead doubling down on Allen’s prime years by shoring up the offensive line and adding depth to the defensive front. With Allen playing at an MVP level, options in the huddle to sling the pigskin to, and a defense that expects to be healthier and deeper, the Bills believe 2025 could be the season they finally break through. Week 1 against Baltimore provides the chance to set the tone with a statement win at home, reminding the AFC that Buffalo’s window to contend remains wide open.
2025 Buffalo Bills Schedule, Results & Record
Buffalo prioritized keeping its core intact, so most of its efforts throughout free agency were about keeping the band together. That included extensions for Josh Allen, Greg Rousseau, Terrel Bernard, Khalil Shakir, and Christian Benford. That said, they did make additions, notably signing wideout Josh Palmer and edge rusher Joey Bosa. Palmer has routinely been underrated, and Bosa, so long as he's healthy, will help apply pressure off the edge.
In the 2025 NFL Draft, defense was the priority, and for good reason. Buffalo's defense was a key reason the Bills were unable to get over the hump and reach the Super Bowl, particularly due to their struggles on third down. Well, they answered that by adding speedy corner Maxwell Hairston in the first round and then spent Day 2 largely focused on the offensive line with defensive tackle TJ Sanders and edge rusher Landon Jackson. There weren't any major splashes for the Bills, but it was a strong offseason nonetheless.
Buffalo Bills Past Seasons (2000)
| YEAR |
RECORD |
PLAYOFFS |
| 2024 |
13-4 |
Lost Conference Championship |
| 2023 |
11-6 |
Lost Divisional Round |
| 2022 |
13-3 |
Lost Divisional Round |
| 2021 |
11-6 |
Lost Divisional Round |
| 2020 |
13-3 |
Lost Conference Championship |
| 2019 |
10-6 |
Lost Wild Card Round |
| 2018 |
6-10 |
None |
| 2017 |
9-7 |
Lost Wild Card Round |
| 2016 |
7-9 |
None |
| 2015 |
8-8 |
None |
| 2014 |
9-7 |
None |
| 2013 |
6-10 |
None |
| 2012 |
6-10 |
None |
| 2011 |
6-10 |
None |
| 2010 |
4-12 |
None |
| 2009 |
6-10 |
None |
| 2008 |
7-9 |
None |
| 2007 |
7-9 |
None |
| 2006 |
7-9 |
None |
| 2005 |
5-11 |
None |
| 2004 |
9-7 |
None |
| 2003 |
6-10 |
None |
| 2002 |
8-8 |
None |
| 2001 |
3-13 |
None |
| 2000 |
8-8 |
None |
Buffalo prioritized keeping its core intact, so most of its efforts throughout free agency were about keeping the band together. That included extensions for Josh Allen, Greg Rousseau, Terrel Bernard, Khalil Shakir, and Christian Benford. That said, they did make additions, notably signing wideout Josh Palmer and edge rusher Joey Bosa. Palmer has routinely been underrated, and Bosa, so long as he's healthy, will help apply pressure off the edge.
In the 2025 NFL Draft, defense was the priority, and for good reason. Buffalo's defense was a key reason the Bills were unable to get over the hump and reach the Super Bowl, particularly due to their struggles on third down. Well, they answered that by adding speedy corner Maxwell Hairston in the first round and then spent Day 2 largely focused on the offensive line with defensive tackle TJ Sanders and edge rusher Landon Jackson. There weren't any major splashes for the Bills, but it was a strong offseason nonetheless.
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