2025-2026 Friday Night College Football Week 12 Betting Lines

2025-2026 College Football Friday Night Betting Online

NCAA Friday Night Football Betting

The Friday Night College Football schedule for Week 12 takes place on Friday, November 14, 2025. There are two games on the schedule with the Louisville Cardinals a slight home favorite in college football odds against the Clemson Tigers on ESPN and the No. 7 Oregon Ducks big favorites at home against the Minnesota Golden Gophers on FOX. The game on FOX will be a chance for Oregon to impress the nation, as the Ducks are still in contention to make the College Football Playoff.

The 12th week of Friday night action for the 2025-2026 college football season features two games. It is Clemson at Louisville on ESPN and Minnesota at Oregon on FOX.

College Football Same Game Parlay Lines

Week 12 - Friday, November 14, 2025

Clemson Tigers (4–5, 3–6 ATS) at Louisville Cardinals (7–2, 3–6 ATS), 7:30 pm ET, ESPN

The Cardinals are a slight home favorite in NCAA football odds in this game against Clemson. The Clemson Tigers enter this matchup at 4–5 overall and 3–6 ATS, averaging 27.9 points per game on 409.3 total yards (288.4 passing, 120.9 rushing). They allow 22.4 points and 351.3 yards (245.1 passing, 106.2 rushing). Quarterback Cade Klubnik has thrown for 2,136 yards, while Adam Randall leads both the rushing attack with 570 yards and the team in touchdowns with 6. Bryant Wesco Jr. has been the top receiving target with 537 yards. Defensively, Clemson has been strong against the run, ranking 19th nationally at 106.2 yards allowed per game, but turnovers (13) have been costly.

Louisville comes in at 7–2 overall and 3–6 ATS, averaging 37.0 points per game on 451.6 total yards (277.4 passing, 174.3 rushing). They allow 24.4 points and 333.9 yards (211.6 passing, 122.3 rushing). Quarterback Miller Moss has thrown for 2,132 yards, with Isaac Brown pacing the ground game at 782 rushing yards and Chris Bell leading the receivers with 792 yards. Defensively, the Cardinals rank 32nd against the run (122.3) and 57th against the pass (211.6), with 12 takeaways on the season.

Matchup keys: Clemson’s ability to protect Klubnik and sustain drives against Louisville’s opportunistic defense, and whether Louisville’s balanced offense can break through Clemson’s run defense. The Tigers will look to lean on Randall’s dual role as rusher and scorer, while the Cardinals aim to exploit their passing depth with Moss and Bell.

Betting angle: Both teams have struggled ATS (Clemson 3–6, Louisville 3–6), making both teams a risk to bet on. Louisville’s higher scoring profile (37.0 points per game) contrasts with Clemson’s more modest output, but both defenses sit in the middle tier nationally. Totals lean slightly over for Louisville (5–4) and balanced for Clemson (4–5).

Minnesota Golden Gophers (6–3, 2–6–1 ATS) at Oregon Ducks (8–1, 4–4–1 ATS), 9:00 pm ET, FOX

The Ducks are big home favorites in this Friday night contest. The Minnesota Golden Gophers enter this matchup at 6–3 overall and 2–6–1 ATS, averaging 23.8 points per game on 313.1 total yards (203.3 passing, 109.8 rushing). They allow 21.6 points and 311.6 yards (203.4 passing, 108.1 rushing). Quarterback Drake Lindsey has thrown for 1,743 yards, while Fame Ijeboi leads the ground game with 384 rushing yards. Le’Meke Brockington has been the top receiving target with 385 yards. Defensively, Minnesota ranks 20th nationally in total yards allowed, with strength against the run (21st at 108.1 yards per game), but their offense has struggled to sustain drives.

No. 7 Oregon comes in at 8–1 overall and 4–4–1 ATS, averaging 38.7 points per game on 471.6 total yards (231.9 passing, 239.7 rushing). They allow just 13.8 points and 239.3 yards (126.1 passing, 113.2 rushing). Quarterback Dante Moore has thrown for 1,884 yards, with Noah Whittington pacing the rushing attack at 551 yards and Jordon Davison leading the team with 10 touchdowns. Dakorien Moore tops the receiving corps with 443 yards. Defensively, the Ducks are elite, ranking 3rd nationally in total yards allowed and 1st against the pass, giving them one of the most complete profiles in the Big Ten.

Matchup keys: Minnesota’s ability to protect Lindsey and generate balance against Oregon’s suffocating defense. The Ducks will look to dominate with their rushing attack and force Minnesota into obvious passing downs, while the Gophers aim to slow the game and lean on their defense to keep it close.

Betting angle: Minnesota has struggled ATS (2–6–1), while Oregon sits at 4–4–1, reflecting more consistency. Totals are close for both teams (Minnesota 5–4, Oregon 4–5).

Each year, the college football schedule for Friday night action reveals that major colleges are seeking any means and path to generate revenue, while schools with lower profiles are looking for additional exposure. Naturally, lesser-known teams from the Group of Five conferences are eager to take the field on Friday nights when the bigger brands are off. This strategy allows them the full attention of fans, gamblers, and, most importantly, prospective recruits. Teams that would normally be ignored on a full Saturday find that the entire nation is focused on their Friday night matchups.

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2025-2026 Friday Night College Football Schedule

Week 13 - Friday, November 21, 2025

Florida State Seminoles at NC State Wolfpack, 8 pm, ESPN

Hawaii Warriors at UNLV Rebels, 10:30 pm, FS1

Week 14 - Friday, November 28, 2025

Iowa Hawkeyes at Nebraska Cornhuskers, noon, CBS

Kent State Golden Flashes at NIU Huskies, noon, TBD

Ohio Bobcats at Buffalo Bulls, noon, TBD

Utah Utes at Kansas Jayhawks, noon, TBD

Ole Miss Rebels at Mississippi State Bulldogs, noon, TBD

Georgia Bulldogs at Georgia Tech Yellow Jackets, 3:30 pm, ABC

San Diego State Aztecs at New Mexico Lobos, 3:30 pm, CBSSN

Boise State Broncos at Utah State Aggies, 4 pm, CBS

Texas A&M Aggies at Texas Longhorns, 7:30 pm, ABC

Indiana Hoosiers at Purdue Boilermakers, 7:30 pm, NBC

Army Black Knights at UTSA Roadrunners, TBD

Temple Owls at North Texas Mean Green, TBD

Arizona Wildcats at Arizona State, TBD, FOX

Air Force Falcons at Colorado State Rams, TBD, FS1

Week 15 - Friday, December 5, 2025

Conference USA Championship Game, 7 pm, CBSSN

Sun Belt Conference Championship Game, 7 pm, ESPN

AAC Championship Game, 8 pm, ABC

Mountain West Conference Championship Game, TBD, FOX

Football Betting Bonus

2025-2026 College Football Schedule

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