College Football Week 5 Best Bets - Football Lines
Week 5 of the 2025 college football season delivers the first truly massive weekend of the campaign with multiple Top 10 matchups that will have significant implications for both the College Football Playoff picture and conference championship races. The slate features premier showdowns across multiple conferences as teams begin to separate themselves from pretenders in what promises to be a defining weekend. Saturday's action is headlined by No. 6 Oregon traveling to No. 3 Penn State for the White Out at Beaver Stadium in a rematch of last season's Big Ten Championship Game, while the SEC takes center stage with crucial conference battles including No. 4 LSU at No. 13 Ole Miss and No. 17 Alabama visiting No. 5 Georgia in prime time.
The weekend represents a critical juncture where championship aspirations will be tested and conference hierarchies will begin to take shape. With undefeated teams finally facing legitimate competition, Week 5 serves as the first major measuring stick for how the expanded 12-team College Football Playoff race will unfold. Multiple programs enter with perfect records but face their toughest challenges to date, setting up potential statement wins that could define entire seasons. The Big Ten and SEC lead the way with marquee matchups, while other conferences feature intriguing storylines that could reshape the national landscape.
Week 5 delivers the type of high-stakes college football that defines championship seasons, with prime television coverage across all major networks ensuring fans won't miss any of the action. From afternoon clashes to primetime spectacles, the weekend promises the kind of memorable moments that college football fans live for, with multiple games carrying both immediate and long-term consequences for the playoff chase.
Let’s look at the Week 5 college football schedule and spotlight Oregon at Penn State, LSU at Mississippi and Alabama at Georgia.
College Football Betting Lines
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2025-2026 College Football Week 5 Schedule
Thursday, September 25, 2025
7:30 p.m. | Army at East Carolina | ESPN
Friday, September 26, 2025
7 p.m. | Florida State at Virginia | ESPN
9 p.m. | TCU at Arizona St. | FOX
10:30 p.m. | Houston at Oregon St. | ESPN
Saturday, September 27, 2025
12 p.m. |USC at Illinois | FOX
12 p.m. | Georgia Tech at Wake Forest | ESPN
12 p.m. | Notre Dame at Arkansas | ABC
12:00 p.m. | Rutgers at Minnesota | BTN
12:00 p.m. | Duke at Syracuse | ACCN
12:00 p.m. | Louisville at Pittsburgh | ESPN2
12:00 p.m. | Cincinnati at Kansas | TNT
12:00 p.m. | UCF at Kansas State | FS1
12:00 p.m. | South Alabama at North Texas | ESPNU
12:00 p.m. | Bowling Green at Ohio | CBSSN
12:00 p.m. | Stetson at Dayton | YouTube
12:00 p.m. | New Haven at Duquesne
12:00 p.m. | Delaware State at Sacred Heart | ESPN+
12:00 p.m. | Cornell at Yale | ESPN+
12:00 p.m. | Norfolk State at Wagner
12:00 p.m. | Dartmouth at Central Connecticut State
12:00 p.m. | Penn at Lehigh | ESPN+
12:00 p.m. | Georgetown at Columbia | ESPN+
12:45 p.m. | Utah State at Vanderbilt | SEC Network
1:00 p.m. | Eastern Michigan at Central Michigan | ESPN+
1:00 p.m. | Marist at Butler
1:00 p.m. | LIU at Stonehill
1:00 p.m. | Holy Cross at Fordham | ESPN+
1:00 p.m. | UAlbany at New Hampshire
1:00 p.m. | Towson at Bryant
1:00 p.m. | Morehead State at Presbyterian | ESPN+
1:30 p.m. | Georgia Southern at James Madison | ESPN+
2:00 p.m. | Miles at Morgan State
2:00 p.m. | Utah Tech at Austin Peay | ESPN+
2:00 p.m. | South Dakota at North Dakota State | ESPN+
2:00 p.m. | Hampton at Elon
2:00 p.m. | Howard at Richmond | ESPN+
2:00 p.m. | St. Thomas (MN) at San Diego | ESPN+
3:00 p.m. | Arkansas State at UL Monroe | ESPN+
3:00 p.m. | Alabama A&M at Bethune-Cookman
3:00 p.m. | Alabama State at Florida A&M
3:00 p.m. | Idaho State at Northern Colorado | ESPN+
3:00 p.m. | Mercyhurst at South Dakota State | ESPN+
3:30 p.m. | Ohio State at Washington | CBS / Paramount+
3:30 p.m. | LSU at Ole Miss | ABC
No. 4 LSU makes its first SEC road trip of the season to face No. 13 Ole Miss on Saturday afternoon in Oxford, with kickoff scheduled for 2:30 p.m. on ABC at Vaught-Hemingway Stadium. Both teams enter undefeated with the Tigers at 4-0 and the Rebels at 4-0, marking the first major ranked SEC showdown of the season and the Rebels are a slight home favorite in NCAA football odds. LSU quarterback Garrett Nussmeier has emerged from early-season struggles and a torso injury to guide the Tigers to four straight wins, while Ole Miss quarterback Austin Simmons has the Rebels' explosive offense ranking among the nation's most productive units.
The Tigers last won in Oxford in 2019 with a 58-37 victory, but the Rebels have taken the last two meetings there, including a 55-49 thriller in 2023. LSU's defense, which held Southeastern Louisiana to just 30 yards in the first half last week, will face its toughest test against an Ole Miss offense that has recorded 19 receptions of 20-plus yards this season, second-most in the nation.
3:30 p.m. | Auburn at Texas A&M | ESPN
3:30 p.m. | Utah at West Virginia | FOX
3:30 p.m. | Indiana at Iowa | Peacock
3:30 p.m. | UCLA at Northwestern | BTN
3:30 p.m. | California at Boston College | ACCN
3:30 p.m. | Baylor at Oklahoma State | ESPN2
3:30 p.m. | UConn at Buffalo | ESPN+
3:30 p.m. | San Diego State at Northern Illinois | ESPN+
3:30 p.m. | Rice at Navy | CBSSN
3:30 p.m. | Akron at Toledo | ESPN+
3:30 p.m. | Western Carolina at Campbell
3:30 p.m. | Princeton at Lafayette | ESPN+
3:30 p.m. | Furman at Samford | ESPN+
3:30 p.m. | Merrimack at Stony Brook
3:30 p.m. | William & Mary at Villanova
3:30 p.m. | North Carolina A&T at Maine
3:30 p.m. | Lindenwood at Miami (OH)
4:00 p.m. | New Mexico State at New Mexico
4:00 p.m. | Tulane at Tulsa | ESPNU
4:00 p.m. | Eastern Illinois at Western Illinois | ESPN+
4:00 p.m. | Eastern Washington at Montana State | ESPN+
4:10 p.m. | Hawaii at Air Force | FS1
4:15 p.m. | Tennessee at Mississippi State | SEC Network
4:30 p.m. | Tennessee Tech at Tennessee State | ESPN+
5:00 p.m. | Northern Arizona at Portland State | ESPN+
5:00 p.m. | Texas Southern at Mississippi Valley State
5:30 p.m. | Mercer at East Tennessee State | ESPN+
6:00 p.m. | Middle Tennessee at Kennesaw State | ESPN+
6:00 p.m. | Liberty at Old Dominion | ESPN+
6:00 p.m. | South Carolina State at Charleston Southern | ESPN+
6:00 p.m. | Saint Francis (PA) at Bucknell | ESPN+
6:00 p.m. | Brown at Harvard | ESPN+
6:00 p.m. | Nicholls at Eastern Kentucky
6:00 p.m. | The Citadel at Chattanooga | ESPN+
6:30 p.m. | Rhode Island at Western Michigan | ESPN+
7:00 p.m. | Arizona at Iowa State | ESPN
7:00 p.m. | Virginia Tech at NC State | The CW
7:00 p.m. | Southeast Missouri State at UT Martin | ESPN+
7:00 p.m. | Jacksonville State at Southern Miss | ESPN+
7:00 p.m. | Western Kentucky at Missouri State | ESPN+
7:00 p.m. | Memphis at Florida Atlantic | ESPN2
7:00 p.m. | UTRGV at Southeastern Louisiana | ESPN+
7:00 p.m. | Abilene Christian at UIW | ESPN+
7:00 p.m. | North Carolina Central at Texas A&M–Commerce | ESPN+
7:00 p.m. | Central Arkansas at Lamar | ESPN+
7:00 p.m. | Prairie View A&M at Grambling
7:00 p.m. | Alcorn State at Arkansas–Pine Bluff
7:00 p.m. | Jackson State at Southern | ESPN+
7:30 p.m. | Oregon at Penn State | NBC / Peacock
No. 6 Oregon travels to Happy Valley for a White Out showdown against No. 3 Penn State on Saturday night, with kickoff set for 7:30 p.m. on NBC at Beaver Stadium. This highly anticipated rematch of last season's Big Ten Championship Game, which Oregon won 45-37, features two undefeated teams with championship aspirations facing their first major test of the season. The Ducks enter 4-0 behind quarterback Dante Moore, who has thrown for 657 yards and seven touchdowns while leading an offense that has dominated through four games.
Penn State counters with a 3-0 record and one of the nation's most suffocating defenses, allowing just 5.7 points per game and ranking among the leaders in tackles for loss under new defensive coordinator Jim Knowles. The White Out atmosphere at Beaver Stadium provides Penn State with one of college football's most intimidating home-field advantages in what could be the game of the year.
7:30 p.m. | Alabama at Georgia | ABC
No. 17 Alabama travels to Athens for a prime-time SEC showdown against No. 5 Georgia on Saturday night, with kickoff set for 7:30 p.m. on ABC at Sanford Stadium. The Crimson Tide enters 2-1 under first-year head coach Kalen DeBoer, seeking a statement win that could define his second season in Tuscaloosa after missing the College Football Playoff in his debut campaign.
Georgia brings a 3-0 record and has won 32 consecutive games at Sanford Stadium, the longest active home winning streak in FBS, with their last home loss coming to South Carolina in 2019. Quarterback Gunner Stockton has guided the Bulldogs' offense this season, while Alabama's Ty Simpson has thrown for 862 yards and nine touchdowns through three games. The game represents a potentially season-defining moment for both programs, with Alabama needing to prove it can still compete at the highest level under DeBoer, while Georgia looks to maintain its stranglehold on home dominance in what is a great rivalry game.
7:30 p.m. | Massachusetts at Missouri | ESPNU
7:30 p.m. | Washington State at Colorado State | CBSSN
7:30 p.m. | San Jose State at Stanford | ACCN
7:45 p.m. | Kentucky at South Carolina | SEC Network
8:00 p.m. | McNeese at Stephen F. Austin | ESPN+
8:30 p.m. | West Georgia at Southern Utah | ESPN+
9:00 p.m. | Cal Poly at Sacramento State | ESPN+
10:00 p.m. | Weber State at UC Davis | ESPN+
10:15 p.m. | BYU at Colorado | ESPN
10:15 p.m. | Idaho at Montana | ESPN+
2025-2026 College Football Schedule
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