College Football Week 11 Best Bets - Football Lines
Week 11 college football arrives with the playoff race tightening and heavyweight clashes across the country. The spotlight falls first on the Big 12, where No. 8 BYU travels to No. 9 Texas Tech in a top-10 showdown that has drawn College GameDay back to Lubbock for the first time since 2008. The unbeaten Cougars face their stiffest test yet against a Red Raiders team averaging over 40 points per game and boasting one of the nation’s stingiest defenses. With both teams in the thick of the Big 12 title hunt, this matchup doubles as a playoff eliminator.
In the SEC, No. 3 Texas A&M visits No. 19 Missouri at 3:30 p.m. on ABC. The Aggies remain unbeaten and are pushing toward Atlanta, while Missouri looks to spring an upset at home behind its balanced offense and physical defense. The battle in the trenches will be decisive, as A&M’s explosive attack meets a Tiger front that has been stout against the run.
The primetime stage belongs to Tuscaloosa, where No. 4 Alabama hosts LSU at 7:30 p.m. on ABC. The Crimson Tide, led by quarterback Ty Simpson, are surging toward another SEC West crown, while LSU enters under interim leadership and desperate to salvage its season. The rivalry always delivers intensity, and this year’s edition carries massive playoff stakes for Alabama and spoiler potential for the Tigers.
Elsewhere, the Top 5 are all in action. No. 1 Ohio State heads to Purdue for what is expected to be an easy road win at Ross-Ade Stadium. The Buckeyes will look to stay perfect behind quarterback Julian Sayin and a defense that just stifled Penn State. No. 2 Indiana travels to Penn State, aiming to extend its school-record winning streak to 10 games. The Hoosiers, led by Fernando Mendoza, face a Nittany Lions squad reeling from a five-game losing streak and major injuries. And No. 5 Georgia visits Mississippi State in what could be a tricky road game.
With multiple Top-15 matchups and every Top-5 team in action, Week 11 stands as a defining checkpoint in the national title chase. Contenders must prove their staying power, while hopefuls fight to keep their postseason dreams alive.
Week 11 delivers the type of high-stakes college football that defines championship seasons, with prime television coverage across all major networks ensuring fans won't miss any of the action. From afternoon clashes to primetime spectacles, the weekend promises the kind of memorable moments that college football fans live for, with multiple games carrying both immediate and long-term consequences for the playoff chase.
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2025-2026 College Football Week 11 Schedule
Tuesday, November 4, 2025
7 p.m. | UMass at Akron | CBSSN
7 p.m. | Miami (Ohio) at Ohio | ESPN2
Wednesday, November 5, 2025
7 p.m. | Kent State at Ball State | ESPNU
7 p.m. | Northern Illinois at Toledo | ESPN2
Thursday, November 6, 2025
7:30 p.m. | Georgia Southern at Appalachian State | ESPN2
7:30 p.m. | UTSA at South Florida | ESPN
Friday, November 7, 2025
8 p.m. | Houston at UCF | FS1
9 p.m. | Northwestern at USC | FOX
9 p.m. | Tulane at Memphis | ESPN
Saturday, November 8, 2025
12 p.m. | Georgia at Mississippi State
12 p.m. | BYU at Texas Tech
The Red Raiders are laying double-digits at home in this game. The BYU Cougars enter unbeaten, averaging 36.3 points per game while allowing just 17.0. Quarterback Bear Bachmeier has thrown for 1,693 yards and 11 touchdowns with only three interceptions, while running back LJ Martin leads the ground game with 789 rushing yards and 5 TDs. Wideout Chase Roberts has been the go-to target, approaching 600 receiving yards. Defensively, BYU has thrived on balance, holding opponents under 130 rushing yards per game and forcing 12 interceptions through eight contests.
The Texas Tech Red Raiders are 8-1 after a 43–20 win over Kansas State, powered by a defense that forced five turnovers. Quarterback Behren Morton has been efficient, completing nearly 69% of his passes for 1,501 yards and 13 touchdowns. Running back Cameron Dickey (678 yards, 9 TDs) and receiver Caleb Douglas (512 yards, 6 TDs) headline a balanced attack. Tech is among the nation’s most explosive teams, ranking 3rd nationally in scoring offense (43.6 ppg) and 5th in scoring defense (13.2 ppg).
Their front seven has been dominant, with David Bailey leading the nation in sacks (11.5) and Jacob Rodriguez pacing the country in forced fumbles (7).
This matchup has drawn College GameDay to Lubbock for the first time since 2008, underscoring its national significance. With BYU unbeaten and Texas Tech surging, the game could hinge on turnovers and red-zone efficiency. BYU’s secondary has been opportunistic, but Tech’s defensive front has been overwhelming. The winner will take a major step toward the Big 12 title race and remain firmly in the College Football Playoff conversation.
12 p.m. | SMU at Boston College | ACC Network
12 p.m. | Indiana at Penn State | FOX
12 p.m. | Colorado at West Virginia | TNT/truTV
12 p.m. | James Madison at Marshall | ESPN2
12 p.m. | Southern Miss at Arkansas State | ESPNU
12 p.m. | Temple at Army | CBSSN
1 p.m. | Ohio State at Purdue | Big Ten Network
1 p.m. | The Citadel at Ole Miss | SECN+
1 p.m. | Missouri State at Liberty | ESPN+
1 p.m. | Bowling Green at Eastern Michigan | ESPN+
2 p.m. | UAB at Rice | ESPN+
2:30 p.m. | Maryland at Rutgers | FS1
3 p.m. | Louisiana Tech at Delaware | ESPN+
3 p.m. | Florida International at Middle Tennessee | ESPN+
3 p.m. | Jacksonville State at UTEP | ESPN+
3 p.m. | Charlotte at East Carolina | ESPN+
3 p.m. | Tulsa at Florida Atlantic | ESPN+
3:30 p.m. | Texas A&M at Missouri | ABC
The Aggies are small road favorites in this contest. The Texas A&M Aggies remain unbeaten after a statement win over LSU two weeks ago, averaging 34.8 points per game on 412.6 total yards (238.7 passing, 173.9 rushing). Defensively, they’ve been one of the SEC’s best, allowing just 16.4 points per game and 298.2 yards (184.1 passing, 114.1 rushing). Quarterback Connor Weigman has thrown for 2,012 yards, 17 touchdowns, and 5 interceptions, while running back Le’Veon Moss leads the ground game with 711 yards and 8 scores. Wideout Evan Stewart has been the top target with 682 receiving yards and 6 TDs. The Aggies’ front seven has been dominant, piling up 29 sacks through eight games, and their secondary has forced 11 interceptions.
The Missouri Tigers sit at 6-3 overall and 3-3 in SEC play, averaging 28.7 points per game on 397.4 total yards (246.2 passing, 151.2 rushing). Defensively, they allow 23.9 points per game and 364.8 yards (221.6 passing, 143.2 rushing). Quarterback Brady Cook has thrown for 2,118 yards, 15 touchdowns, and 6 interceptions, while running back Nate Noel has added 654 rushing yards and 7 TDs. Wideout Luther Burden III remains the centerpiece of the passing attack with 812 receiving yards and 5 scores.
Missouri’s defense has been opportunistic, forcing 14 turnovers, but has struggled against physical rushing teams.
This SEC clash pits A&M’s balanced offense and suffocating defense against Missouri’s playmakers. For the Aggies, the key will be continuing to control the line of scrimmage and limiting explosive plays from Burden. For Missouri, protecting Cook and establishing Noel on the ground will be critical to keeping the Aggies’ pass rush honest. With A&M chasing its first SEC Championship Game berth since joining the league, and Missouri fighting for bowl positioning, the stakes are high in Columbia.
3:30 p.m. | Syracuse at Miami (Fla.) | ESPN
3:30 p.m. | Duke at UConn | CBSSN
3:30 p.m. | Oregon at Iowa | CBS
3:30 p.m. | Kansas at Arizona | ESPN2
3:30 p.m. | Iowa State at TCU | FOX
4 p.m. | Auburn at Vanderbilt | SEC Network
4 p.m. | Kennesaw State at New Mexico State | ESPN+
4 p.m. | Georgia State at Coastal Carolina | ESPN+
4:30 p.m. | Washington at Wisconsin | Big Ten Network
4:30 p.m. | Stanford at North Carolina | The CW Network
5 p.m. | Texas State at Louisiana | ESPN+
6 p.m. | Air Force at San Jose State | FS1
7 p.m. | Wake Forest at Virginia
7 p.m. | Cal at Louisville
7 p.m. | Florida State at Clemson
7:30 p.m. | LSU at Alabama | ABC
Alabama is a double-digit favorite in NCAA football odds in this game. The LSU Tigers enter Tuscaloosa at 5-3 overall and 2-3 in SEC play, coming off a bye week but still reeling from a midseason coaching change. LSU is averaging 31.1 points per game on 421.7 total yards (262.4 passing, 159.3 rushing), while allowing 24.8 points and 372.6 yards (223.7 passing, 148.9 rushing). Quarterback Garrett Nussmeier has thrown for 2,014 yards, 17 touchdowns, and 8 interceptions, while running back Kaleb Jackson leads the ground game with 612 yards and 7 TDs. Wideout Kyren Lacy has been the top target with 589 receiving yards and 5 scores. Defensively, LSU has struggled to generate consistent pressure, recording just 15 sacks through eight games, and their secondary has been vulnerable against top passing attacks.
The Alabama Crimson Tide remain unbeaten in SEC play as they are 7-1 overall and 5-0 in the league and they are coming off a bye week. Alabama is averaging 29.8 points per game on 398.4 total yards (231.6 passing, 166.8 rushing), while allowing just 14.9 points and 289.2 yards (178.1 passing, 111.1 rushing). Quarterback Ty Simpson has thrown for 1,876 yards, 14 touchdowns, and 4 interceptions, while running back Justice Haynes has added 721 rushing yards and 9 TDs. Wideout Kobe Prentice leads the receiving corps with 602 yards and 4 scores. Defensively, Alabama has been dominant, ranking top-10 nationally in scoring defense and sacks, with linebacker Deontae Lawson pacing the team at 61 tackles.
This rivalry clash carries massive SEC West implications. For LSU, the key will be protecting Nussmeier and finding explosive plays through Lacy to offset Alabama’s defensive front. For Alabama, the formula remains balance: establish Haynes on the ground, let Simpson work play-action, and trust a defense that has been suffocating at home. With LSU in transition and Alabama eyeing Atlanta, the Tide enter as clear favorites, but rivalry games in November rarely follow the script.
7:30 p.m. | Navy at Notre Dame | NBC/Peacock
7:30 p.m. | Florida at Kentucky | SEC Network
7:30 p.m. | Nevada at Utah State | CBSSN
9 p.m. | Nebraska at UCLA | FOX
9:30 p.m. | UNLV at Colorado State | FS1
10 p.m. | Sam Houston at Oregon State | The CW Network
11 p.m. | San Diego State at Hawaii
2025-2026 College Football Schedule
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