College Football Week 12 Best Bets - Football Lines
Week 12 college football arrives with the playoff race entering its decisive stretch and heavyweight clashes across the country. The spotlight falls first on the ACC, where Notre Dame travels to Pittsburgh in a noon kickoff on ABC. The Irish have surged back into contention behind quarterback C.J. Carr and a balanced rushing attack, while Pitt has quietly pieced together a strong season and will look to ride its physical defense and home-field edge to a statement upset. With both teams still alive in the conference race, the matchup doubles as a playoff litmus test.
In the SEC, all eyes turn to Tuscaloosa, where Alabama hosts Oklahoma in a rare November showdown between two of the league’s top brands. The Crimson Tide, led by Ty Simpson and a defense that just shut down LSU, are pushing toward another SEC West crown. Oklahoma, meanwhile, enters its second SEC season with a chance to shake up the playoff picture and prove it belongs among the nation’s elite. The atmosphere at Bryant-Denny will be electric, with playoff stakes on the line for both sides.
The primetime stage belongs to Athens, where Georgia welcomes Texas in a rematch of last year’s SEC title game. Gunner Stockton and the Bulldogs are chasing another trip to Atlanta, while Arch Manning and the Longhorns arrive with their season hanging in the balance. Georgia’s defense will be tested by Texas’ vertical passing game, and the outcome could determine not only the SEC East but also the playoff bracket.
Elsewhere, the Top 5 are all in action. No. 1 Ohio State hosts UCLA in a Big Ten matchup where the Buckeyes will look to stay perfect behind Julian Sayin and a defense that has dominated all season. No. 2 Indiana faces Wisconsin, aiming to extend its school-record winning streak and keep pace in the Big Ten title chase. No. 3 Texas A&M welcomes South Carolina to Kyle Field, with the Aggies seeking to remain unbeaten and strengthen their playoff résumé.
With multiple Top-15 matchups and every playoff contender in action, Week 12 stands as a defining checkpoint in the national title chase. Contenders must prove their staying power, while hopefuls fight to keep their postseason dreams alive.
Week 12 delivers the type of high-stakes college football that defines championship seasons, with prime television coverage across all major networks ensuring fans won't miss any of the action. From afternoon clashes to primetime spectacles, the weekend promises the kind of memorable moments that college football fans live for, with multiple games carrying both immediate and long-term consequences for the playoff chase.
Let’s look at the Week 12 college football schedule and spotlight No. 9 Notre Dame at No. 23 Pittsburgh on ABC, No. 11 Oklahoma at No. 4 Alabama on ABC and No. 10 Texas at No. 5 Georgia on ABC.
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2025-2026 College Football Week 12 Schedule
Tuesday, November 11, 2025
7:30 p.m. | Kent State at Akron | ESPNU
8 p.m. | Ohio at Western Michigan | ESPN2
Wednesday, November 12, 2025
7 p.m. | Buffalo at Central Michigan | CBSSN
7 p.m. | NIU at UMass | ESPNU
7 p.m. | Toledo at Miami (Ohio) | ESPN2
Thursday, November 13, 2025
7:30 p.m. | Troy at Old Dominion | ESPN
Friday, November 14, 2025
7:30 p.m.| Clemson at Louisville | ESPN
9 p.m. | Minnesota at Oregon | FOX
Saturday, November 15, 2025
12 p.m. | Wisconsin at Indiana | Big Ten Network
12 p.m. | South Carolina at Texas A&M | ESPN
12 p.m. | Michigan at Northwestern | FOX
12 p.m. | Notre Dame at Pitt | ABC
The Fighting Irish are laying points on the road in this game at Pittsburgh. Notre Dame enters averaging 274.0 passing yards and 187.6 rushing yards per game, scoring 37.4 while allowing 19.9. Quarterback C.J. Carr has thrown for 2,275 yards, supported by Jeremiyah Love’s 988 rushing yards and Jordan Faison’s 545 receiving. The Irish defense has been steady, though opponents have converted 38.5% on third down, a potential vulnerability against high-tempo attacks.
Pittsburgh comes in with a 7–2 overall mark and a 5–1 ACC record, powered by one of the nation’s top passing offenses at 309.3 yards per game. The Panthers average 39.8 points while allowing 21.5. Quarterback Mason Heintschel has passed for 1,547 yards, with Ja’Kyrian Turner leading the ground game at 399 yards and Kenny Johnson pacing the receivers with 573. Pitt’s run game has lagged at 122.5 yards per contest, but the aerial attack has kept them in the ACC race.
This matchup pits Notre Dame’s balanced offense against Pittsburgh’s explosive passing game. The Irish will look to control tempo with Love’s rushing production, while Pitt aims to exploit Notre Dame’s third-down defense. If Carr maintains efficiency and the Irish sustain drives, Notre Dame should dictate the pace. If Heintschel and Johnson stretch the field and force conversions, the Panthers have the formula for an upset.
12 p.m. | Arizona at Cincinnati | FS1
12 p.m. | Kansas State at Oklahoma State| ESPNU
12 p.m. | Air Force at UConn | CBSSN
12 p.m. | UTSA at Charlotte | ESPN+
12 p.m. | South Fla. at Navy | ESPN2
12 p.m. | Eastern Michigan at Ball State| ESPN+
12:45 p.m. | Arkansas at LSU| SEC Network
1:00 p.m. | Oregon State at Tulsa | ESPN+
1:00 p.m. | West Virginia at Arizona State | TNT
1:30 p.m. | Tennessee Tech at Kentucky| SEC Network +
2:00 p.m. | Marshall at Georgia State | ESPN+
2:00 p.m. | North Texas at UAB | ESPN+
3:00 p.m. | UTEP at Missouri State | ESPN+
3:30 p.m. | Oklahoma at Alabama | ABC
The Crimson Tide are laying points at home in this SEC showdown. Alabama enters at 8–1 overall and 6–0 in conference play, averaging 403.1 total yards per game (291.2 passing, 111.9 rushing) and scoring 32.8 points while allowing just 17.2. Quarterback Ty Simpson has thrown for 2,461 yards, supported by a passing attack ranked 15th nationally. The Tide defense has been stout, holding opponents to 303.2 yards per game and ranking 14th in scoring defense at 17.2 points allowed. Their ATS mark sits at 6–2–1 with a 4–5 O/U record.
Oklahoma comes in at 7–2 overall and 3–2 in the SEC, averaging 373.7 total yards per game (236.7 passing, 137.0 rushing) and scoring 28.9 points while allowing only 14.1. The Sooners’ defense has been elite, ranking 7th nationally in total yards allowed (264.2) and 4th against the run (82.4). Their ATS record is 4–4–1 with a 2–7 O/U mark, reflecting a defense-first profile.
This matchup pits Alabama’s balanced offense and top-15 passing game against Oklahoma’s suffocating defense, particularly against the run. The Tide will look to protect Simpson and exploit their passing edge, while the Sooners aim to shorten the game with defense and force Alabama into long drives. If Alabama establishes rhythm through the air and avoids turnovers, they should control the tempo. If Oklahoma’s front seven dictates the line of scrimmage and keeps this low-scoring, the Sooners have the formula for an upset.
3:30 p.m. | UCF at Texas Tech | FOX
3:30 p.m. | Virginia at Duke | ESPN2
3:30 p.m. | Georgia Tech at Boston College | ACC Network
3:30 p.m. | NC State at Miami (Fla.) | ESPN
3:30 p.m. | Iowa at USC | TBA
3:30 p.m. | Penn State at Michigan State | TBA
3:30 p.m. | Maryland at Illinois | FS1
3:30 p.m. | Middle Tennessee at Western Kentucky| ESPN+
3:30 p.m. | San José State at Nevada | CBSSN
3:30 p.m. | App State at James Madison | ESPN+
3:30 p.m. | South Alabama at UL Monroe | ESPN+
3:30 p.m. | Texas State at Southern Miss | ESPN+
4:00 p.m. | Memphis at East Carolina | ESPNU
4:00 p.m. | Florida Atlantic at Tulane | ESPN+
4:15 p.m. | New Mexico St. at Tennessee | SEC Network
4:30 p.m. | North Carolina at Wake Forest | The CW Network
5:00 p.m. | Liberty at FIU | ESPN+
6:00 p.m. | Coastal Carolina at Georgia Southern | ESPN+
7 p.m. | Florida at Ole Miss | ESPN
7 p.m. | Utah at Baylor | ESPN2
7 p.m. | Purdue at Washington | FS1
7 p.m. | Delaware at Sam Houston | ESPN+
7 p.m. | Utah State at UNLV | CBSSN
7:30 p.m. | UCLA at Ohio State | NBC
7:30 p.m. | Texas at Georgia | ABC
The Bulldogs are favored at home in this SEC clash. Georgia enters at 8–1 overall and 6–1 in conference play, averaging 420.0 total yards per game (236.0 passing, 184.0 rushing) and scoring 32.5 points while allowing 19.6. Quarterback Gunner Stockton has thrown for 1,776 yards, with Chauncey Bowens leading the ground game at 446 rushing yards and Zachariah Branch pacing the receivers with 474 yards. Defensively, Georgia ranks 19th in total yards allowed (309.4), 11th against the run (94.1), and 24th in scoring defense (19.6). Their ATS record sits at 4–4–1 with a 4–4–1 O/U mark, reflecting balance but no clear betting trend.
Texas comes in at 7–2 overall and 4–1 in the SEC, averaging 381.4 total yards per game (246.1 passing, 135.3 rushing) and scoring 29.6 points while allowing just 16.4. The Longhorns’ defense has been elite against the run, ranking 2nd nationally at 78.2 yards allowed per game, and 11th in scoring defense at 16.4 points allowed. Their ATS record is 2–6–1 with a 4–5 O/U mark, showing they’ve struggled to cover spreads despite strong defensive metrics.
Georgia’s 4–4–1 ATS record is middling, but Texas has been one of the least reliable teams against the spread at 2–6–1. Both teams hover around .500 on totals (Georgia 4–4–1, Texas 4–5), suggesting no clear advantage on the over/under numbers.
7:30 p.m. | Virginia Tech at Florida State | ACC Network
7:45 p.m. | Mississippi St. at Missouri | SEC Network
8 p.m. | Kennesaw State at Jacksonville State | ESPNU
10 p.m. | Louisiana Tech at Washington State | The CW Network
10:15 p.m. | TCU at BYU |ESPN
10:30 p.m. | Boise State at San Diego State | CBSSN
10:30 p.m. | Wyoming at Fresno State | FS1
2025-2026 College Football Schedule
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