2025-2026 College Football Week 2 Betting Online
For 2025, Week 2 bears some resemblance to Week 1, as there will be numerous matchups between FCS and FBS programs. Such arrangements are typically a win-win for both parties. The FCS program receives a substantial payment to serve as cannon fodder for the FBS program, which receives what everyone thinks will be an automatic win and cover. Of course, the problem arises when the FCS team pulls off an upset, which can be so catastrophic that it ruins seasons and coaching careers. So too do gamblers discover that the betting odds are so high in favor of the FBS home side that the lesser FCS teams often get the money with room to spare.
College Football Betting Lines
One of the oldest rivalries in college football has been dormant since 2012, but will finally renew in Week 2. The Missouri Tigers will host the Kansas Jayhawks in the oldest rivalry west of the Mississippi River. Most importantly, both teams have emerged as quality programs.
One of the biggest megabrand matchups of the entire season will take place in Norman, Oklahoma, where the Oklahoma Sooners will host the Michigan Wolverines. Brent Venables is in his third season at the helm of OU and needs a breakout season after two disappointing campaigns. Venables flirted with big years but was unable to close in November in both campaigns. Michigan took a big step back in 2024 after winning the 2023 national championship. Second-year head coach Sherrone Moore is on the clock after receiving a Mulligan as a rookie head coach.
2025-2026 College Football Week 2 Schedule
Friday, September 5, 2025
James Madison Dukes at Louisville Cardinals, 7 pm, ESPN2
NIU Huskies at Maryland Terrapins, 7:30 pm, BTN
Western Illinois Leathernecks at Northwestern Wildcats, 7:30 pm, BTN
Eastern Washington Eagles at Boise State Broncos, 9 pm FS1
Saturday, September 6, 2025
Northwestern State Demons at Minnesota Golden Gophers, noon, BTN
Kennesaw State Owls at Indiana Hoosiers, noon, FS1
FIU Panthers at Penn State Nittany Lions, noon, BTN
Baylor Bears at SMU Mustangs, noon, The CW
Virginia Cavaliers at NC State Wolfpack, noon, ESPN2
Kent State Golden Flashes at Texas Tech Red Raiders, noon, TNT
East Texas A&M Lions at Florida State Seminoles, noon, ACCN
Liberty Flames at Jacksonville State Gamecocks, noon, CBSSN
Illinois Fighting Illini at Duke Blue Devils, noon, TBD
Iowa Hawkeyes at Iowa State Cyclones, noon, FOX
San Jose State Spartans at Texas Longhorns, noon, TBD
UConn Huskies at Syracuse Orange, noon, ESPN+
Central Michigan Chippewas at Pitt Panthers, noon, ESPNU
Utah State Aggies at Texas A&M Aggies, 12:45 pm, SECN
Western Carolina Catamounts at Wake Forest Demon Deacons, ESPN+
Howard Bison at Temple Owls, 2 pm, ESPN+
Gardner-Webb Bulldogs at Georgia Tech Yellow Jackets, ACCN
Troy Trojans at Clemson Tigers, 3:30 pm, ACCN
Texas State Bobcats at UTSA Roadrunners, 3:30 pm, ESPN+
Saint Francis U Red Flash at Buffalo Bulls, 3:30 pm, ESPN+
Oklahoma State Cowboys at Oregon Ducks, 3:30 pm, CBS
Kansas Jayhawks at Missouri Tigers, 3:30 pm, ESPN2
Fresno State Bulldogs at Oregon State Beavers, 3:30 pm, The CW
Austin Peay Governors at Georgia Bulldogs, 3:30 pm, ESPN+
Bryant Bulldogs at UMass Minutemen, 3:30, ESPN+
UAB Blazers at Navy Midshipmen, 3:30 pm, CBSSN
Ole Miss Rebels at Kentucky Wildcats, 3:30 pm, ABC
Lindenwood Lions at Appalachian State Mountaineers, 3:30 pm, ESPN+
Bowling Green Falcons at Cincinnati Bearcats, 3:30 pm, ESPN+
Miami-OH Redhawks at Rutgers Scarlet Knights, 3:30 pm, Peacock
Grambling State Tigers at Ohio State Buckeyes, 3:30 pm, BTN
Delaware Blue Hens at Colorado Buffaloes, 3:30 pm, FOX
North Texas Mean Green at Western Michigan Broncos, 3:30 pm, ESPN+
ETSU Buccaneers at Tennessee Volunteers, 3:30 pm, ESPN+
West Virginia Mountaineers at Ohio Bobcats, 4 pm, ESPNU
Middle Tennessee State Blue Raiders at Wisconsin Badgers, 4 pm, FS1
USF Bulls at Florida Gators, 4:15 pm, SECN
Arkansas State Red Wolves at Arkansas Razorbacks, 5 pm, SECN+
Jackson State Tigers at Southern Miss Eagles, 5 pm, ESPN+
NC Central Eagles at Old Dominion Monarchs, 6 pm, ESPN+
Campbell Camels at East Carolina Pirates, 6 pm, ESPN+
Cal Poly Mustangs at Utah Utes, 6 pm, ESPN+
Missouri State Bears at Marshall Thundering Herd, 6 pm, ESPN+
Texas Southern Tigers at California Golden Bears, 6 pm, ESPN+
Florida A&M Rattlers at Florida Atlantic Owls, 6 pm, ESPN+
Memphis Tigers at Georgia State Panthers, 7 pm, ESPN+
WKU Hilltoppers at Toledo Rockets, 7 pm, ESPN+
Tulane Green Wave at South Alabama Jaguars, 7 pm, ESPN+
North Carolina Tar Heels at Charlotte 49ers, 7 pm, ESPN+
Houston Cougars at Rice Owls, 7 pm, ESPN+
Army Black Knights at Kansas State Wildcats, 7 pm, ESPN
Bethune-Cookman Wildcats at Miami-FL Hurricanes, 7 pm, ESPN+
SC State Bulldogs at South Carolina Gamecocks, SECN+
North Carolina A&T Aggies at UCF Knights, 7 pm, ESPN+
LIU Sharks at Eastern Michigan Eagles, 7 pm, ESPN+
Ball State Cardinals at Auburn Tigers, 7:30 pm, ESPNU
Vanderbilt Commodores at Virginia Tech Hokies, 7:30, ACCN
Michigan Wolverines at Oklahoma Sooners, 7:30, ABC
Charleston Southern Buccaneers at Coastal Carolina Chanticleers, 7:30 pm, ESPN+
Louisiana Tech Bulldogs at LSU Tigers, 7:30 pm, ESPN+
Arizona State Sun Devils at Mississippi State Bulldogs, 7:30 pm, NBC
Akron Zips at Nebraska Cornhuskers, 7:30 pm, BTN
Boston College Eagles at Michigan State Spartans, 7:30 pm, NBC
Southern Illinois Salukis at Purdue Boilermakers, 7:30 pm, BTN
Georgia Southern Eagles at USC Trojans, 7:30 pm, FS1
ULM Warhawks at Alabama Crimson Tide, 7:45 pm, SECN
McNeese Cowboys at Louisiana Ragin’ Cajuns, 8 pm, ESPN+
UCLA Bruins at UNLV Rebels at 8 pm, CBSSN
UT Martin Skyhawks at UTEP Miners, 9 pm, ESPN+
Tulsa Golden Hurricane at New Mexico State Aggies, 9 pm, ESPN+
Weber State Wildcats at Arizona Wildcats, 10 pm, ESPN+
Stanford Cardinal at BYU Cougars, 10:15 pm, ESPN
San Diego State Aztecs at Washington State Cougars, 10:15 pm, The CW
UC Davis Aggies at Washington Huskies, 11 pm, BTN
Idaho State Bengals at New Mexico Lobos, TBD
Sam Houston Bearkats at Hawaii Warriors, TBD
Sacramento State Hornets at Nevada Wolf Pack, TBD
Northern Colorado Bears at Colorado State Rams, TBD
Northern Iowa Panthers at Wyoming Cowboys, TBD
2025-2026 College Football Schedule
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