Oregon at Penn State in B1G Saturday Night Clash on NBC

CFB Week 5 Oregon at Penn State Odds and Preview

Last year, the Penn State Nittany Lions met the Oregon Ducks in the Big Ten Championship Game. Oregon was a new member of the Big Ten and was taking less money than the established schools to join. However, the Big Ten should have been giving Oregon a raise after winning the league in 2024. Now, Penn State gets a shot at revenge at home on Saturday. The Ducks and Nittany Lions will play in the famed annual White Out at Beaver Stadium. So far, Penn State and Oregon is the biggest matchup of 2025.

Explore the latest College Football betting lines, odds, and predictions for Week 5.

College Football Betting Lines

Oregon Ducks at Penn State Nittany Lions Odds at Bookmaker

Beaver Stadium in Happy Valley (University Park, PA) is the venue for Saturday night’s White Out game between the Penn State Nittany Lions and visiting Oregon Ducks. The Saturday, September 27, 2025, matchup will kick off at 7:30 p.m. ET on NBC.

The Oregon Ducks opened as a 3.5-point road dog with the Penn State Nittany Lions as a 3.5-point home favorite.

The Ducks and Nittany Lions opened with a total of 52.5.

On the moneyline, Oregon opened as a +145 road dog with Penn State as a -175 home chalk.

Oregon Ducks

Last game, the Oregon Ducks won 41-7 against the Oregon State Beavers as 34-point home favorites. The game went under the total of 58.

Oregon is 4-0 straight up, 2-1-1 against the spread, and 2-2 over the total.

Overall, Oregon has national metrics of 12th for total offense, 7th for scoring offense, and 12th for fewest turnovers committed.

By contrast, Oregon ranks 12th for total defense, 9th for points allowed, and 36th for takeaways.

Sixth-ranked Oregon tuned up for its massive Big Ten showdown at Penn State next weekend. Hence, the Ducks scored a romp over in-state rival Oregon State on Saturday afternoon in Eugene, Ore.

Overall, the Ducks racked up 585 yards of total offense.

Quarterback Dante Moore completed 21 of 31 passes for 305 yards with four touchdowns. Moore, along with six other running backs, helped the Ducks gain 280 yards on the ground.

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Penn State Nittany Lions

Last week, the Penn State Nittany Lions won 52-6 against the FCS Villanova Wildcats as 47.5-point home favorites. The game went over the total of 56.6.

Penn State is 3-0 straight up, 0-3 against the spread, and 2-1 over the total.

In sum, Penn State has national metrics of 47th for total offense, 13th for scoring offense, and 8th for fewest turnovers committed. In comparison, Penn State ranks 9th for total defense, 3rd for points allowed, and 26th for takeaways.

Nicholas Singleton ran for two touchdowns, and Drew Allar threw for another as No. 2 Penn State cruised past visiting Villanova.

Allar finished 16-of-29 for 209 yards with a touchdown and an interception.

Oregon at Penn State Betting Trends

Oregon has been a strong value on the road. To show, the Ducks covered ten of their most recent 15 road games.

Seven of the last 11 Oregon road games went under the total.

Specifically at home, Penn State has not been a reliable wagering value. The Nittany Lions got the cash in only four of their previous 13 home games.

Penn State went under the total in eight of its last 12 games.

Last year, in the only previous meeting between these teams, the Ducks beat the Nittany Lions 45-37 as 3-point favorites in the Big Ten championship game. The matchup went over the total of 52.

Oregon at Penn State Best Bets

On this occasion, Oregon will offer more value as the power away team with the odds.

The White Out is going to draw too much square money to Penn State.

Oregon has emerged as a big game hunter.

Main Pick: Oregon Ducks

Over/Under Pick: Under the Total

Player Prop Picks: Drew Allar Under the Passing Yards Total

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