San Francisco 49ers 2025 NFL Betting Odds & Picks
Since Kyle Shanahan took over as head coach of the San Francisco 49ers in 2017, they have made the playoffs four times with two Super Bowl appearances and two losses in the NFC championship game. Following a second Super Bowl heartbreak to the Kansas City Chiefs in February 2024, the Niners were a future market favorite to return the following season. Instead, San Francisco was wiped out by injuries and suffered a lost season with a record of 6-11. For 2025, the 49ers could emerge as a classic beaten favorite that comes back strong, like a quality stock coming off a brief dip. Gamblers certainly like the 49ers in the future market to take the NFC West title.
NFL Betting Lines
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2025 San Francisco 49ers Schedule, Results & Record
The 49ers desperately need their two most recent draft classes to produce and make up for the many veteran departures this offseason. But they already took a hit with the loss of second-year safety Malik Mustapha, who is expected to miss the start of the season after sustaining a knee injury in last year’s finale. San Francisco is banking on its defensive front upgrades in the draft to help star defenders Nick Bosa and Fred Warner. The arrivals of Mykel Williams, Alfred Collins, and Nick Martin could improve the team’s pass rush and run defense.
But the 49ers neglected their needs on the offensive line and have a hole at guard with Aaron Banks signing with the Green Bay Packers. Brock Purdy should be O.K. without Deebo Samuel, who was traded to the Washington Commanders, because the team used a 2024 first-round pick on Ricky Pearsall and re-signed Brandon Aiyuk and Jauan Jennings the prior offseason. The inexperienced players should get a boost from Trent Williams and Christian McCaffrey if they stay healthy this season.
San Francisco 49ers Past Seasons(2000)
| YEAR |
RECORD |
PLAYOFFS |
| 2024 |
6-11 |
None |
| 2023 |
12-5 |
Lost Super Bowl |
| 2022 |
13-4 |
Lost Conference Championship |
| 2021 |
10-7 |
Lost Conference Championship |
| 2020 |
6-10 |
None |
| 2019 |
13-3 |
Lost Super Bowl |
| 2018 |
4-12 |
None |
| 2017 |
6-10 |
None |
| 2016 |
2-14 |
None |
| 2015 |
5-11 |
None |
| 2014 |
8-8 |
None |
| 2013 |
12-4 |
Lost Conference Championship |
| 2012 |
11-4-1 |
Lost Super Bowl |
| 2011 |
13-3 |
Lost Conference Championship |
| 2010 |
6-10 |
None |
| 2009 |
8-8 |
None |
| 2008 |
7-9 |
None |
| 2007 |
5-11 |
None |
| 2006 |
7-9 |
None |
| 2005 |
4-12 |
None |
| 2004 |
2-14 |
None |
| 2003 |
7-9 |
None |
| 2002 |
10-6 |
Lost Divisional Round |
| 2001 |
12-4 |
Lost Wild Card Round |
| 2000 |
6-10 |
None |
Born in 1946 as members of the All-American Football Conference, the San Francisco 49ers have a rich history that has earned them a spot among the NFL’s legacy franchises.
The 49ers won the last AAFC championship in 1949 before the league merged into the NFL. From 1950 through 1969, the 49ers made the playoffs only once.
From 1970 through 1972, the 49ers won the NFC West three consecutive seasons and made the NFC championship game twice. Quarterback John Brodie and wide receiver Gene Washington starred for those teams.
In 1981, the 49ers forged their first dynasty. Bill Walsh led them to three Super Bowl championships from 1981 through 1988. And the team he built won another one under George Seifert the year after Walsh retired. Also, Seifert won the franchise’s final Super Bowl in 1994. San Francisco missed the playoffs only once, from 1983 through 1998.
Since 2012, the 49ers have made three more Super Bowls, losing each time.
A great and proud lineage of players has lit up the 49ers' marquee. Joe Montana, Steve Young, Jerry Rice, Roger Craig, Ronnie Lott, and Dwight Clark are just some of the great 49ers legends.
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