Indianapolis Colts Week 1 Best Bets - NFL Betting Lines

Indianapolis Colts Week 1 Best Bets - NFL Betting Lines

The Indianapolis Colts enter the 2025 NFL betting season looking to prove they can climb out of the AFC South basement and compete against stronger competition. Oddsmakers have tempered expectations, posting 130-1 Super Bowl betting odds, +6500 conference odds, and +320 odds to win the AFC South title. Their NFL win total is set at 6.5 games, a reflection of cautious market confidence that Indianapolis has the talent to improve but still faces challenges. Colts Fans can now wager on the NFL futures odds using crypto across BookMaker Sportsbook, a promotion tied directly to the team’s loyal following.

The spotlight is firmly on Anthony Richardson, the fourth overall pick in the 2023 NFL Draft. After flashes of promise in an injury-shortened rookie season, Richardson is expected to lead a roster loaded with offensive playmakers. If the Colts’ quarterback can take a leap in development, Indianapolis could outperform its current NFL futures odds and reward backers betting the NFL this season.

Colts vs. Dolphins Week 1 Betting Lines

Spread: Colts -1

Total: 47

Money Line: Colts -125, Dolphins +105

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Indianapolis Colts Week 1 Matchup

On Sunday, September 7, 2025, the Indianapolis Colts will host the Miami Dolphins at Lucas Oil Stadium in Indianapolis, Indiana. Kickoff is scheduled for 1:00 p.m. ET with television coverage on CBS. Sportsbooks opened the NFL point spread with Indianapolis as -1.5 favorites, but early NFL line movement has driven the spread down to a pick ’em at most shops. The total opened at 45.5 points and has climbed to 46.5, indicating bettors expect more offense than oddsmakers originally projected.

For Indianapolis, the key storyline is whether Richardson can deliver on the big stage in a game that will attract national NFL betting attention. The Colts are tasked with backing up their 16–10 win over Miami from last season, a result that cashed for anyone taking Indianapolis at -3 on the NFL spread. This year’s rematch offers a different test as Miami brings a revamped roster, and oddsmakers have responded with tight NFL betting lines that reflect the uncertainty surrounding Richardson and the Colts’ offense.

Injuries will be a factor for the Week 1 NFL odds. Alec Pierce and Josh Downs are questionable at receiver, while the defense lists Samson Ekubam and Kwity Paye as questionable up front. Protecting Richardson is another concern with Bernhard Raimann also uncertain. These injuries impact not only how bettors view the NFL point spread but also whether totals bettors can expect sustained drives.

Historically, Indianapolis has been steady at home. The Colts are 6–4 straight up and 5–5 against the spread in their last ten at Lucas Oil Stadium, a trend that gives bettors little clarity but confirms they can hang with quality opponents. Against Miami specifically, Indianapolis cashed last season as home chalk, and bettors will once again look for value in the Week 1 NFL betting lines.

For totals bettors, the rising number from 45.5 to 46.5 underscores expectations of a higher-scoring contest. NFL Over/Under betting trends suggest the public often favors Overs early in the season, and this line movement reflects that sentiment.

Indianapolis Colts 2024-25 Recap

Indianapolis’ 2024 season was marked by inconsistency and growing pains. The Colts finished 8–9 straight up, 9–8 against the spread, and 10–7 to the Over, making them one of the league’s better Over teams for NFL totals bettors. Their ability to cash Overs reflected both offensive explosiveness and defensive struggles, a duality that kept Indianapolis in entertaining but volatile games.

The futures markets rarely saw much confidence in the Colts, and bettors found the team unpredictable against the NFL betting odds. While their 9–8 ATS mark suggested they were competitive, it was often hard to time when they would exceed market expectations. Their Over-heavy profile became the only consistent angle for NFL wagering, with Richardson’s ability to create big plays balanced by a defense prone to giving them up.

Richardson’s limited playing time due to injuries left more questions than answers. Still, his athletic upside makes him a focal point of Indianapolis’ outlook throughout the 2025-26 campaign. The offense has enough weapons to surprise, but whether they outperform NFL spread picks consistently depends on Richardson’s growth under center. Defensively, lapses in coverage and an inability to get off the field on third down plagued them, leaving bettors wary of backing the Colts in tight NFL betting markets.

Looking ahead, the Colts enter 2025 with modest expectations but real upside for those willing to take a chance on their NFL futures odds. With Richardson at the helm, Indianapolis could outperform its 6.5-game win total and provide value in NFL spread picks throughout the season. Week 1 against Miami serves as the first measuring stick — not just for the team but also for NFL bettors deciding whether the Colts are worth backing early.

2025 Indianapolis Colts Schedule, Results & Record

Indy's secondary was rough in 2024, allowing 229.4 passing yards per game during the regular season (seventh-worst in the NFL). Given that glaring weakness, it makes sense that it was a main emphasis during free agency, with corner Charvarius Ward and safety Camryn Bynum brought in. Their arrivals instantly raised the floor of the pass defense.

While the Colts did a good job fixing the secondary, gamblers have some serious questions about the offensive line. Despite losing Ryan Kelly and Will Fries in free agency, they didn't take a lineman until the fourth round (Jordan Travis, OT, Iowa State).

Meanwhile, there is now a looming quarterback battle with Daniel Jones coming in to compete with Anthony Richardson. But if Jones actually wins the job, will the Colts truly be happy with that outcome? That means their former No. 4 overall quarterback in Richardson, is a lost cause.

Indianapolis Colts Past Seasons (2000)

In 1984, during the middle of the night, the Baltimore Colts snuck out of town with Mayflower moving vans to take up residence in Indianapolis, Indiana. For Baltimore fans, it was a personal tragedy. For residents of the Hoosier State, the Colts gave them a much-needed big-league status.

The Baltimore Colts were one of the most successful franchises in NFL history. Led by the famed Johnny Unitas at quarterback, the Colts put the NFL on the map with their overtime win at the New York Giants in the 1958 championship game. The Colts also suffered the greatest upset loss in history. In Super Bowl III, the New York Jets defeated the Colts 16-7 as 18.5-point underdogs. Baltimore went on to win Super Bowl V two years later.

Since 1995, the Colts have been one of the most successful franchises in pro football. Indianapolis has missed the playoffs just nine times since then. Of course, much of that success was due to Peyton Manning, who led them to two Super Bowl appearances with one win. Indeed, Lucas Oil Stadium is the House that Peyton Built.

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