At the onset of the season, the Cincinnati Bengals and Denver Broncos were among the most popular selections in the future market.
The Bengals got off to a strong start with wins in their first two games. Last week, however, in Minnesota, the Bengals were annihilated in Minnesota. QB Joe Burrow is out, and that changes all dynamics.
Meanwhile, the Denver Broncos are coming off a loss to the Los Angeles Chargers in a key AFC West matchup.
Denver was coming off a painful road loss to the Indianapolis Colts, which followed a strong home win over the Tennessee Titans.
Monday’s matchup has AFC playoff implications.
Explore the latest Week 4 NFL betting lines and predictions for Monday Night Football.
NFL Betting Lines
Cincinnati Bengals at Denver Broncos Odds at Bookmaker
Empower Field at Mile High Stadium in Denver, CO, is the venue for the Monday, September 29, 2025, matchup between the Denver Broncos and Cincinnati Bengals. Kickoff is at 8:15 p.m. ET with television coverage on ABC.
The Cincinnati Bengals opened as 7.5-point road dogs with the Denver Broncos as 7.5-point home favorites.
The Bengals and Broncos opened with a total of 44.5.
Cincinnati is a +295 moneyline dog with the Broncos as -375 moneyline favorites.
Cincinnati Bengals
Last week, the Cincinnati Bengals lost 48-10 to the Minnesota Vikings as 3-point road dogs. The game went over the total of 43.5.
As a result, the Bengals are 2-1 straight up, 1-2 against the spread, and 2-1 over the total.
Cincinnati ranks 32nd for total offense, 24th for scoring, and 32nd for fewest turnovers committed. By contrast, the Bengals rank 24th for total defense, 26th for scoring defense, and 6th for takeaways.
Isaiah Rodgers returned an interception 87 yards for a touchdown. Additionally, he added a 66-yard fumble return for a score. Rodgers became the first defensive player in NFL history to force two fumbles and score a pair of defensive touchdowns.
Consider that the Vikings scored 31 points off five Cincinnati turnovers. In sum, Cincinnati fumbled the ball five times, losing three of them.
Meanwhile, Jake Browning threw two interceptions. Browning, starting his first game since Joe Burrow’s left foot surgery on Friday, finished 19-of-27 for 140 yards with a late touchdown pass.
Denver Broncos
Last game, the Denver Broncos lost 23-20 at the Los Angeles Chargers as 3-point dogs. The game went under the total of 45.5.
Now, Denver is 1-2 straight up, 0-2-1 against the spread, and 1-2 under the total.
Overall, the Broncos rank 20th for total offense, 18th for scoring, and 28th for fewest turnovers committed. Denver ranks 18th in total defense, 16th in scoring defense, and 26th in takeaways.
Justin Herbert passed for 300 yards. And then Cameron Dicker made a 43-yard field goal as time expired to give the Los Angeles Chargers a victory over the Denver Broncos.
Broncos running back J.K. Dobbins ran for 83 yards and a touchdown against his former team.
Bo Nix passed for 153 yards and a touchdown while rushing for 33 yards.
Denver lost on a game-ending field goal for the second consecutive game.
Bengals at Broncos Betting Trends
The Bengals have been a solid betting value on the road with 10 covers in their most recent 16 away games. Five of the last eight Cincinnati road games went over the total.
The Broncs have been a good value at home. Denver covered ten of its most recent 15 games at Empower Field. The Broncos went over the total in only one of their most recent five home games.
In the series between Cincinnati and Denver, the Bengals got the cash in 10 of the last 15 meetings. Only two of the last six games between the Broncos and Bengals went over the total.
Specifically in Denver, the Bengals covered five consecutive games against the Broncos. The last three games in this series at Denver failed to go over the total.
Bengals at Broncos Best Bets
On this occasion, the Bengals offer more value as a competitive club at a road team price. As was previously noted, Cincinnati owns this series. Burrow’s absence only adds to the enhanced betting odds value.
Main Pick: Cincinnati Bengals
Over/Under Pick: Under the Total
Player Prop Picks: Bo Nix Under the Passing Yards Total
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