Previously, for the past couple of seasons, the Detroit Lions and Kansas City Chiefs were considered as a potential Super Bowl matchup.
This year, the Chiefs’ slow start has fans and gamblers doubting their Super Bowl viability. But the Chiefs remain one of the most resilient teams for wagering action. Just when you count out the Chiefs, that is when they are most dangerous.
On Sunday night, the Chiefs will host the Lions. Last week, the Chiefs jumped out to a 14-0 lead at Jacksonville, only to lose in the final seconds 31-28.
Meanwhile, Detroit is coming off a big win and payout against the Cincinnati Bengals.
A Sunday Night matchup between two power brands who could meet in the Super Bowl will draw massive betting activity, splitting to both sides.
Explore the latest Week 6 NFL betting lines and predictions for Sunday Night Football.
NFL Betting Lines
Detroit Lions at Kansas City Chiefs Odds at Bookmaker
GEHA Field at Arrowhead Stadium, Kansas City, MO, will host the interconference matchup between the Detroit Lions and Kansas City Chiefs on Sunday, October 12, 2025, at 8:20 p.m. ET. This is the NBC Sunday Night matchup.
Oddsmakers opened with the Lions as 1.5-point road dogs and the Chiefs as 1.5-point home favorites.
On the moneyline, the Lions are -104, while Kansas City is a -112 moneyline favorite.
The Lions and Chiefs opened with a total of 50.5.
Detroit Lions
Last game, the Detroit Lions won 37-24 against the Cincinnati Bengals as 10.5-point road favorites. The game went over the total of 48.5.
Detroit is 4-1 straight up, 4-1 against the spread, and 3-2 over the total.
Detroit ranks 7th for total offense, 13th for passing, 7th for rushing, 1st for scoring, and 7th for fewest turnovers committed.
Detroit has NFL metrics of 6th for total defense, 11th vs. the pass, 7th vs. the rush, and 17th for fewest points allowed.
Kansas City Chiefs
Last Monday night, the Kansas City Chiefs lost 31-28 against the Jacksonville Jaguars as 3.5-point road favorites. The game went over the total of 45.5.
The Chiefs are 2-3 straight up, 2-3 against the spread, and 3-2 over the total.
Kansas City ranks 1st for total offense, 1st for passing, 4th for rushing, 15th for scoring, and 4th for fewest turnovers committed.
Kansas City has NFL metrics of 29th for total defense, 24th vs. the pass, 30th vs. the rush, 5th for fewest points allowed, and 11th for takeaways.
Lions at Chiefs Betting Trends
Detroit has been a strong betting value on the road. The Lions got the cash in eight of their most recent ten road games.
Detroit went over the total in 11 of its last 20 road matchups.
Kansas City covered only five of its most recent 12 home games.
The Chiefs are 6-6 over and under the total at Arrowhead.
In the series between the Chiefs and Lions, Detroit got the cash in three of the most recent four visits.
Eight of the last nine meetings between the Chiefs and Lions went over the total.
Specifically, at Arrowhead, the Chiefs have won the cash in four of their most recent five home games against the Lions.
Four of the last five games between the Chiefs and Lions at Kansas City went over the total.
Lions at Chiefs Best Bets
In this situation, fans and gamblers are treated to one of the marquee matchups of the year.
Despite its slow start, Kansas City remains a dangerous team at Arrowhead.
Previously, they dominated the Baltimore Ravens as a home dog this season.
Detroit is a mentally tough team, but the Chiefs have the Arrowhead crowd and a team that is toughest when facing adversity.
Main Pick: Kansas City Chiefs
Over/Under Pick: Over the Total
Player Prop Picks: Jared Goff Under the Passing Yards Total
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