Previously this season, the San Francisco 49ers won a 26-23 overtime thriller on the road against the Los Angeles Rams.
Since that result, the Rams, 49ers, and Seattle Seahawks have emerged as the top three teams in the NFC West.
San Francisco has been forced to navigate the continued injury status of quarterbacks Mac Jones and Brock Purdy.
Meanwhile, veteran Matthew Stafford has been able to stay in the Rams lineup effectively.
On Sunday afternoon, the 49ers host the revenge-seeking Rams in one of the most important games of the 2025 season.
This Sunday rivalry showdown is one of the biggest games of the year and will draw significant wagering activity.
Get the latest NFL Week 10 news, check out the current betting lines for the games, and don’t miss the football action, all with the best odds at BookMaker!
Los Angeles Rams at San Francisco 49ers Odds at Bookmaker
Levi’s Stadium in Santa Clara, CA, is the venue for the matchup between the Los Angeles Rams and the San Francisco 49ers on Sunday, November 9, 2025. Kickoff time is at 4:25 p.m. ET with television coverage on FOX.
Oddsmakers opened with Los Angeles as a 3.5-point favorite and San Francisco as a 3.5-point dog.
Los Angeles is a -194 moneyline favorite against San Francisco, which is a +162 moneyline dog.
Los Angeles and San Francisco opened with a total of 49.5.
Los Angeles Rams
Last game, the Los Angeles Rams won 34-10 against the New Orleans Saints as 14.5-point home favorites. The game went to a push on the total of 44.
Los Angeles is 6-2 straight up, 6-2 against the spread, and 3-4-1 over/under the total.
Los Angeles ranks 9th for total offense, 4th for passing, 18th for rushing, 8th for scoring, and 9th for fewest turnovers committed.
Los Angeles ranks 7th in total defense, 13th vs. the pass, 11th vs. the rush, 2nd in fewest points allowed, and 18th in takeaways.
San Francisco 49ers
Last game, the San Francisco 49ers won 34-24 against the New York Giants as 2.5-point road favorites. The game went over the total of 47.
San Francisco is 6-3 straight up, 5-4 against the spread, and 5-3-1 over/under the total.
Overall, San Francisco ranks 13th for total offense, 7th for passing, 26th for rushing, 23rd for scoring, and 27th for fewest turnovers committed.
San Francisco ranks 16th for total defense, 18th vs. the pass, 15th vs. the rush, 10th for fewest points allowed, and 30th for takeaways.
Mac Jones was the QB and was 19/24 for 235 yards with two TDs and no interceptions.
Rams at 49ers Betting Trends
The Rams have been one of the most profitable road teams on the board.
Los Angeles covered the spread in 13 of their last 18 away matchups.
The Rams went under the total in five of their last eight road tilts.
On the other hand, the 49ers have not been a reliable betting value at home.
San Francisco covered the spread in only four of their last ten home games.
The 49ers went under the total in six of their most recent ten home tilts.
In the series between the Rams and 49ers, the Rams got the money in four of their last five meetings.
The Rams and Niners went over the total in five of their last six games.
Specifically in San Francisco, the Rams have cashed in four of their last seven visits against the 49ers, including the last two.
Only two of the last ten games between the Rams and Niners at San Francisco went over the total.
Rams at 49ers Best Bets
First and foremost for gamblers is to check the status of San Francisco QBs Mac Jones and Brock Purdy.
Overall, the 49ers are one of the most popular teams on the board. Especially when they play at home, San Francisco is a popular team with squares.
However, that can mean inflated priced for the Niners at Levi's Stadium.
The Rams are not necessarily a popular brand, but they do carry respect. Sharps will like the revenge angle and the possibility of an enhanced road team price.
Wise Guys consistently love a quality road for the value that they consistently offer.
In this situation, the Rams will offer more value in a series and situation where they excel.
As mentioned earlier, the Rams are a strong road betting value.
Main Pick: Los Angeles Rams
Over/Under Pick: Over the Total
Player Prop Picks: Matthew Stafford Over the Passing Yards Total
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