The New England Patriots and Buffalo Bills have a storied rivalry that dates back a long time.
Since 1960, these two teams have been division rivals in the AFC East, a division they have shared since the American Football League's founding.
The Patriots are struggling to regain their prominence under first-year head coach Mike Vrabel.
On the other hand, the Bills are among the favorites to win the AFC. Buffalo believes that the window is wide open for a Super Bowl bid in 2025. But they also realize that the window could slam shut sooner rather than later.
NBC Sunday Night Football means massive betting activity, especially for a great historic rivalry.
Explore the latest Week 5 NFL betting lines and predictions for Sunday Night Football.
NFL Betting Lines
New England Patriots at Buffalo Bills Odds at Bookmaker
Highmark Stadium in Orchard Park, NY, is the venue for the AFC East matchup between the Buffalo Bills and visiting New England Patriots. Sunday, October 5, 2025, is the date with a kickoff time of 8:20 p.m. ET. This is the NBC Sunday Night matchup.
The New England Patriots are 8.5-point road dogs, while the Buffalo Bills are 8.5-point home favorites.
The Patriots and Bills opened with a total of 49.5.
New England is a +310 moneyline dog with the Bills a -395 moneyline home favorite.
New England Patriots
Last week, the New England Patriots routed the Carolina Panthers 42-13 as 5.5-point home favorites. The game went over the total of 41.5.
New England is 2-2 straight up, against the spread, and over the total.
New England has NFL metrics of 14th for total offense, 8th for passing, 26th for rushing, 11th for scoring, and 27th for fewest turnovers committed.
New England ranks 15th for total defense, 27th against the pass, 3rd against the rush, 10th for fewest points allowed, and 14th for takeaways.
Marcus Jones sparked New England with a pair of huge punt returns, including one for a touchdown.
QB Drake Maye accounted for three touchdowns.
Buffalo Bills
Last game, the Buffalo Bills won 31-19 against the New Orleans Saints. The game went over the total of 49.
Buffalo is 4-0 straight up, 2-2 against the spread, and 3-1 over the total.
Buffalo has NFL metrics of 2nd for total offense, scoring, and fewest turnovers committed.
Buffalo ranks 10th for total defense, 1st against the pass, 31st against the rush, and 17th for fewest points allowed.
Josh Allen threw two touchdown passes and completed 16 of 22 passes for 209 yards.
Patriots at Bills Betting Trends
New England has been a surprisingly good value on the road with four payouts in their last six games in that role.
The Patriots have gone over the total in five of their most recent eight games.
Buffalo has been a solid home value with eight payouts in their most recent 11 home games.
The Bills went over the total in 12 of their last 15 home games.
In the series between the New England Patriots and Buffalo Bills, the Patriots have won 11 of the last 18 meetings.
Six of the last eight meetings between the Patriots and Bills have gone over the total.
Specifically at Buffalo, New England has bossed the cashier’s cage with 14 payouts in their last 20 visits, including the two most recent meetings.
Four of the last six games between the Patriots and Bills at Buffalo went over the total.
Patriots at Bills Best Bets
In this situation, Buffalo will be overpriced as the public wagering choice.
New England will get an enhanced price and has a record of success and good value in this series.
Main Pick: New England Patriots
Over/Under Pick: Over the Total
Player Prop Picks: Josh Allen Under the Passing Yards Total
Make your bets now at BookMaker and get fast Bitcoin payouts, the best odds available anywhere, and don’t forget about live betting at BookMaker Sportsbook!
