Last week, the Kansas City Chiefs had a critically important home game against the Baltimore Ravens.
Baltimore entered the game reeling from its poor defense and two losses in its first three games. Also, the Chiefs were 1-2 and with a punchless offense.
The Chiefs prevailed with a resounding win and cover.
Finally, Kansas City is finding its groove with two consecutive wins.
This week brings a matchup between the Chiefs and the Jacksonville Jaguars.
Rookie head coach Liam Coen is trying to jumpstart the career of Trevor Lawrence, a former top pick in the NFL Draft.
When the Chiefs play, especially in prime time, betting action is hot. Jacksonville’s improvement adds to the gambling appeal.
Explore the latest Week 5 NFL betting lines and predictions for Monday Night Football.
NFL Betting Lines
Kansas City Chiefs at Jacksonville Jaguars Odds at Bookmaker
EverBank Stadium in Jacksonville, FL, will host the AFC matchup between the Kansas City Chiefs and the Jacksonville Jaguars on Monday, October 6, 2025, with an 8:15 p.m. ET kickoff. The matchup is the ABC and ESPN Monday Night game.
The Kansas City Chiefs opened as a 3.5-point road favorite with the Jacksonville Jaguars opening as a 3.5-point home dog.
The Chiefs and Jaguars opened with a total of 46.5.
Kansas City is a -185 moneyline favorite while Jacksonville is a +154 moneyline dog.
Kansas City Chiefs
Last week, the Kansas City Chiefs scored a resounding 37-20 win over the Baltimore Ravens as 2.5-point home dogs. The game went over the total of 48.5.
Kansas City is 2-2 straight up, against the spread, and over the total.
Overall, the Chiefs rank 17th in total offense, 15th in scoring, and 3rd in fewest turnovers committed.
Kansas City ranks 13th for total defense, 8th against the pass, 22nd against the rush, and 7th for fewest points allowed.
Patrick Mahomes tossed four touchdowns to become the youngest quarterback to reach 250 for his career.
Mahomes went 25-for-36 passing for 270 yards.
Jacksonville Jaguars
In their last game, the Jacksonville Jaguars won 26-21 over the San Francisco 49ers as 3.5-point road underdogs. The game went over the total of 46.
The Jaguars are 3-1 straight up, 3-1 against the spread, and 2-2 over the total.
Jacksonville has NFL metrics of 10th for total offense and 16th for scoring.
Jacksonville ranks 14th for total defense, 24th against the pass, 4th against the rush, 4th for fewest points allowed, and 1st for takeaways.
Trevor Lawrence completed 21 of 31 passes for 174 yards and a TD.
Chiefs at Jaguars Betting Trends
Kansas City has delivered the dough in only three of its most recent ten away games.
The Chiefs went under the total in four of their last six away games.
Jacksonville failed to cover only one of its most recent eight home games.
The Jags went under the total in five of their last six home games.
In the series between Jacksonville and Kansas City, the Chiefs got the cash in seven of their last nine games.
Six of the last seven games between the Chiefs and Jags went under the total.
Specifically in Jacksonville, the Chiefs came away with the cash in four consecutive visits.
Two of the last three games between the Chiefs and Jaguars at Jacksonville went under the total.
Chiefs at Jaguars Best Bets
The Chiefs have struggled to hold betting value on the road.
The Jaguars have been a strong value at home.
Main Pick: Jacksonville Jaguars
Over/Under Pick: Under the Total
Player Prop Picks: Trevor Lawrence Over the Passing Yards Total
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