Last year, the Washington Commanders had the advantage of not being taken seriously with the NFL odds.
Head coach Dan Quinn and rookie quarterback Jayden Daniels led an ambush of the NFL.
Washington ended up in the NFC championship game and was touted as a team of the future.
However, with 2025 comes the full attention and respect of the rest of the NFL. Washington and Daniels are no longer able to ambush opponents.
On Sunday, the Commanders have a tough road assignment against the Los Angeles Chargers on FOX.
Daniels was out last week due to an injury but is expected to return on Sunday.
Thus, betting interest is high for the marquee matchup of Daniels vs. Justin Herbert.
Explore the latest Week 5 NFL betting lines and predictions for this week.
NFL Betting Lines
Washington Commanders at Los Angeles Chargers Odds at Bookmaker
SoFi Stadium is the venue for the Sunday, October 5, 2025, 4:25 p.m. ET matchup between the Los Angeles Chargers and Washington Commanders. FOX will televise the matchup.
The Washington Commanders are 2.5-point road dogs while the Los Angeles Chargers opened as a 2.5-point home favorite.
The Commanders and Chargers opened with a total of 47.5.
Washington opened as a +120 moneyline dog while the Chargers are -142 moneyline favorites.
Washington Commanders
In their last game, the Washington Commanders lost 34-27 to the Atlanta Falcons as 2.5-point road underdogs. The game went over the total of 43.5.
Washington is 2-2 straight up, against the spread, and over the total.
Washington has NFL metrics of 12th for total offense, 25th for passing, 2nd for rushing, 8th for scoring, and 4th for fewest turnovers committed.
Washington ranks 24th for total defense, 28th against the pass, 13th against the rush, 18th for points allowed, and 25th for takeaways.
Marcus Mariota started for Washington in place of the injured Jayden Daniels.
Mariota threw for 156 yards, two touchdowns, and an interception for the Commanders.
Los Angeles Chargers
Last week, the Los Angeles Chargers lost 21-18 to the New York Giants as 6-point road favorites. The game went under the total of 42.
The Chargers are 3-1 straight up, 2-1-1 against the spread, and 1-3 under the total.
The Chargers rank 8th in total defense, 5th in passing, 21st in rushing, 20th in scoring, and 23rd in fewest turnovers committed.
LA ranks 3rd for total defense, 5th against the pass, 15th against the rush, and 3rd for fewest points allowed.
Justin Herbert was 23-of-41 passing with a season-low 203 yards for the Chargers. His two interceptions came after he entered with one on the season.
Commanders at Chargers Betting Trends
Washington has covered the spread in only two of its most recent seven road games.
The Commanders went under the total in five of their last seven road matchups.
The Chargers lost only three of their most recent 12 home games.
The Chargers went over the total in six of their last seven home games.
In the series between Washington and Los Angeles, the Commanders got the cash in only one of the last six meetings.
The Commanders and Chargers have gone under the total in four of their most recent six meetings.
Specifically in Los Angeles, Washington did not cover its last three visits.
Two of those three games went under the total.
Commanders at Chargers Best Bets
To conclude, the Chargers are the new emerging power of the AFC.
Los Angeles is the more complete team for this matchup.
The Chargers are a strong value at home and in this series.
Main Pick: Los Angeles Chargers
Over/Under Pick: Under the Total
Player Prop Picks: Justin Herbert Over the Passing Yards Total
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