From the 1950s through the 1980s, the Los Angeles Rams and San Francisco 49ers had one of the great pro football rivalries.
But since the Rams moved to St. Louis only to return later, the heat is on and off.
Still, the Rams and Niners have a shot at turning up the heat with an important Thursday night matchup.
The visiting 49ers were doubted when Brock Purdy was sidelined with an injury. Instead, they continued to win, but lost when he returned.
Following wins in their first two games, LA suffered a soul-crushing loss at Philadelphia, casting doubts on their viability.
The Rams rebounded with a big win over the Colts last week.
Interest is high for this crucial NFC West rivalry showdown, which has playoff implications.
Explore the latest Week 5 NFL betting lines and predictions for Thursday Night Football.
NFL Betting Lines
San Francisco 49ers at Los Angeles Rams Odds at Bookmaker
SoFi Stadium in Inglewood, CA, will host the NFC West rivalry showdown between the Los Angeles Rams and the visiting San Francisco 49ers on Thursday, October 2, 2025, at 8:15 p.m. ET. Prime Video will provide the coverage.
The San Francisco 49ers opened as a 5.5-point road dog while the Los Angeles Rams opened as a 5.5-point home favorite.
The Rams and 49ers opened with a total of 47.5.
The 49ers are +210 moneyline dogs while the Rams are -258 moneyline favorites.
San Francisco 49ers
Last game, the San Francisco 49ers lost 26-21 to the Jacksonville Jaguars as 3.5-point home favorites. The game went over the total of 46.
The 49ers are 3-1 straight up, 2-2 against the spread, and 2-2 over the total.
Overall, the 49ers have NFL metrics of 5th for total offense, 2nd for passing, 29th for rushing, 22nd for scoring, and 29th for fewest turnovers committed.
The Niners rank 5th for total defense, 6th for points allowed, but 30th for takeaways.
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Los Angeles Rams
Last week, the Los Angeles Rams won 27-20 against the Indianapolis Colts as 3.5-point home favorites. The game went under the total of 50.
Los Angeles is 3-1 straight up, 3-1 against the spread, and 2-2 over the total.
The Rams have NFL metrics of 4th for total offense, 3rd for passing, 13th for rushing, and 13th for scoring.
LA ranks 9th for total defense and 9th for points allowed.
49ers at Rams Betting Trends
San Francisco failed to get the money in eight of its most recent 11 road games.
The 49ers went over the total in ten of their last 15 road tilts.
Los Angeles has covered 12 of their last 20 home games, including four of their most recent five at SoFi Stadium.
The Rams went under the total in 11 of their last 18 home games.
In the series between San Francisco and Los Angeles, the 49ers covered the spread in 13 of the last 20 meetings.
However, the Rams covered the four most recent games.
Four of the last five games between the 49ers and Rams went over the total.
Specifically in Los Angeles, the 49ers got the money in nine of their last 13 meetings with the Rams.
But the Rams covered the last two games in this series at SoFi Stadium.
The Rams and 49ers went over the total in 11 of their last 16 games at LA.
49ers at Rams Best Bets
The Rams show good wagering value at home.
The 49ers are unreliable values on the road.
The Rams have owned the advantage in this series.
Main Pick: Los Angeles Rams
Over/Under Pick: Over the Total
Player Prop Picks: Matthew Stafford Over the Passing Yards Total
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