College Football Week 9 Best Bets - Football Lines

College Football Week 9 Best Bets - Football Lines

College Football Week 9 Best Bets

Week 9 in college football sets the stage for another pivotal weekend in the national championship race, highlighted by high-stakes conference battles that will help shape the playoff picture as October draws to a close. Saturday’s slate features several key matchups carrying national relevance, led by Mississippi’s trip to Oklahoma in a showdown between explosive offenses that thrive on tempo and talent. Both teams enter with College Football Playoff aspirations, and the meeting in Norman represents an elimination-type scenario in what has become a crowded race for postseason positioning.

Elsewhere in the SEC, Texas A&M travels to Baton Rouge to face LSU in a prime-time clash that will test one of the nation’s most efficient defenses against a high-powered Tiger attack. The Aggies, riding a 7-0 start built on balanced quarterback play and offensive depth, are seeking to cement their top-five ranking and maintain control of the SEC West. LSU, meanwhile, looks to rebound from recent struggles and reassert itself at home, where it has traditionally thrived in night games. The matchup offers a midseason measuring stick for both programs as they jockey for playoff positioning and SEC supremacy.

Rounding out the weekend’s headline games is Missouri’s visit to Vanderbilt — a matchup that suddenly carries weight in the conference standings after both programs have taken substantial steps forward in 2025. Missouri’s physical defense and veteran quarterback leadership will be tested by a Vanderbilt team that continues its rise under Clark Lea, fresh off its highest national ranking in program history. With playoff races tightening and conference hierarchies starting to crystallize, Week 9 arrives as a crucial checkpoint that will begin separating contenders from hopefuls as November approaches.

Week 9 delivers the type of high-stakes college football that defines championship seasons, with prime television coverage across all major networks ensuring fans won't miss any of the action. From afternoon clashes to primetime spectacles, the weekend promises the kind of memorable moments that college football fans live for, with multiple games carrying both immediate and long-term consequences for the playoff chase.

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2025-2026 College Football Week 9 Schedule

Tuesday, October 21, 2025

7 p.m. | Kennesaw State at Florida International | ESPN2

7:30 p.m. | Western Kentucky at Louisiana Tech | CBSSN

Wednesday, October 22, 2025

7:30 p.m. | Middle Tennessee at Delaware | ESPN2

9 p.m. | Missouri State at New Mexico State | CBSSN

Thursday, October 23, 2025

7:30 p.m. | South Alabama at Georgia State | ESPN2

Friday, October 24, 2025

7 p.m. | North Texas at Charlotte | ESPN2

7:30 p.m. | Cal at Virginia Tech | ESPN

10 p.m. | Boise State at Nevada | CBSSN

Saturday, October 25, 2025

12 p.m. | Ole Miss at Oklahoma | ABC

The Sooners are small home favorites in college football odds. Mississippi heads to Norman for one of Week 9’s marquee SEC matchups riding the steady play of quarterback Trinidad Chambliss, who has energized the Rebels’ offense since taking over as starter in late September. The Ferris State transfer has directed Lane Kiffin’s fast-paced attack with composure, spreading the ball effectively to primary targets Cayden Lee and De’Zhaun Stribling, while tight end Dae’Quan Wright remains a key red-zone presence. On the ground, Kewan Lacy has led the team in rushing and power carries behind a line averaging over 4.5 yards per attempt, mixing with Damien Taylor and Logan Diggs in Kiffin’s trademark rotation. Defensively, edge rusher Suntarine Perkins anchors an Ole Miss unit that thrives on disruption and turnover pressure.

Oklahoma counters with quarterback John Mateer, the sophomore who has guided the Sooners’ balanced offense that ranks near the top of the conference in third-down efficiency. True freshman Tory Blaylock headlines the backfield and figures prominently in early-down packages, while receivers Isaiah Sategna III and Deion Burks stretch the field on vertical routes. Tight end Will Huggins has emerged as a reliable safety valve over the middle. The Sooners’ defense, led by linebacker Danny Stutsman and tackle Kaden Green, will be tested by Ole Miss’s tempo and deep personnel rotation up front.

This matchup features two contrasting offensive tempos: Ole Miss’s no-huddle rhythm versus Oklahoma’s methodical balance. Execution inside the red zone and ball control will likely decide a contest between programs still jockeying for top-tier SEC footing.

12 p.m. UCLA at Indiana | FOX

12 p.m. | Syracuse at Georgia Tech

12 p.m. | Virginia at North Carolina | ACC Network

12 p.m. | Northwestern at Nebraska | FS1

12 p.m. | South Florida at Memphis

12 p.m. | Rutgers at Purdue | Big Ten Network

12 p.m. | SMU at Wake Forest | The CW Network

12 p.m. | Kansas State at Kansas | TNT

12 p.m. | Appalachian State at Old Dominion | ESPNU

12 p.m. | Bowling Green at Kent State | ESPN+

12 p.m. | Ohio at Eastern Michigan | CBSSN

12:45 p.m. | Auburn at Arkansas | SEC Network

1 p.m. | Akron at Buffalo | ESPN+

3 p.m. | UConn at Rice | ESPN+

3 p.m. | Utah State at New Mexico

3:30 p.m. | Missouri at Vanderbilt | ESPN

Missouri travels to Vanderbilt for a pivotal SEC showdown with both teams relying on balanced attacks and determined defenses to keep postseason dreams alive. The Commodores are slight favorites in NCAA football odds. For Missouri, senior quarterback Beau Pribula orchestrates the offense with composure, having surpassed 1,300 passing yards on the season while distributing the ball efficiently to a trio of versatile targets in Kevin Coleman Jr., Marquis Johnson, and Daniel Blood. Running back Ahmad Hardy spearheads the run game, consistently producing as an every-down option, supported by the steady presence of tight end Brett Norfleet in both blocking and aerial situations.

Vanderbilt’s offense is guided by quarterback Diego Pavia, who has delivered as a dual-threat leader since transferring in, but its clear difference-maker has been tight end Eli Stowers. Stowers enters the week as the Commodores’ leading receiver with 28 catches for 355 yards and 2 touchdowns—a testament to his expanded impact after switching positions and becoming the top matchup weapon in the passing game. Running back Sedrick Alexander continues to set the pace on the ground, while receiver Junior Sherrill threatens defenses with his speed on the perimeter. This game will likely hinge on each quarterback’s ability to avoid costly mistakes and capitalize in the red zone, with both squads hungry to gain ground in a fiercely competitive SEC race.

3:30 p.m. | Alabama at South Carolina | ABC

3:30 p.m. | BYU at Iowa State | FOX

3:30 p.m. | Toledo at Washington State | The CW Network

3:30 p.m. | NC State at Pitt | ACC Network

3:30 p.m. | UL Monroe at Southern Miss | ESPN+

3:30 p.m.  | Illinois at Washington | Big Ten Network

3:30 p.m. | Minnesota at Iowa | CBS

3:30 p.m. | San Diego State at Fresno State | FS1

3:30 p.m. | Florida Atlantic at Navy | CBSSN

3:30 p.m. | Temple at Tulsa | ESPN+

3:30 p.m. | Ball State at Northern Illinois | ESPN+

3:30 p.m. | UMass at Central Michigan | ESPN+

3:30 p.m. | Western Michigan at Miami (Ohio) | ESPN+

4 p.m. | Wisconsin at Oregon | FS1

4 p.m. | Oklahoma State at Texas Tech

4 p.m. | Baylor at Cincinnati

4:15 p.m. | Texas at Mississippi State | SEC Network

6 p.m. | TCU at West Virginia | ESPN+

7 p.m. | Stanford at Miami (Fla.) | ESPN

7 p.m. | Georgia Southern at Arkansas State | ESPN+

7 p.m. | Louisiana at Troy | ESPN+

7:30 p.m. | Texas A&M at LSU | ABC

Texas A&M enters Baton Rouge with a perfect 7-0 record, aiming to continue its best start in decades and the Aggies are slight favorite in college football odds. Sophomore quarterback Marcel Reed (1,770 passing yards, 15 TDs) directs an Aggie offense that has overcome injuries with the emergence of Rueben Owens II as lead back—Owens enters this week with 327 rushing yards after Le'Veon Moss suffered a midseason injury. Top targets Moose Muhammad III and Noah Thomas create tough matchups for an opposing secondary, and an experienced offensive line has provided Reed ample time to extend plays and move the chains. The defense, led by Shemar Turner and Taurean York, is holding opponents to just over 20 points per game and excels in red zone stops.

LSU returns home after dropping a 31-24 contest at Vanderbilt, marking a pivotal challenge for coach Brian Kelly as his 5-2 squad seeks to regroup in Death Valley. Quarterback Garrett Nussmeier (1,551 yards, 10 TDs) remains the centerpiece of the attack, distributing the ball to receivers Chris Hilton Jr. and Aaron Anderson, while freshman Caden Durham leads the Tigers’ ground game (342 rush yards) with Kaleb Jackson and Harlem Berry also contributing. LSU’s defense will be tested by Reed’s mobility and tempo while focusing on shoring up its third-down and red-zone performance after last week’s defeat. This matchup will be dictated by which quarterback can avoid turnovers and which defense can clamp down when it matters most. Both teams remain in the thick of the SEC West race, and Saturday’s result will carry major postseason implications.

7:30 p.m. | Boston College at Louisville | ACC Network

7:30 p.m. | Michigan at Michigan State | NBC

7:30 p.m. | Colorado State at Wyoming | CBSSN

7:45 p.m. | Tennessee at Kentucky | SEC Network

8 p.m. | Houston at Arizona State

10:15 p.m. | Colorado at Utah | ESPN

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2025-2026 College Football Schedule

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