College Football Week 3 Best Bets - Football Lines
Week 3 of the 2025 college football season kicks off on Thursday, September 11, with NC State visiting Wake Forest in an intriguing ACC clash. The action continues Friday night with Indiana State traveling to Indiana, while several other important matchups begin to unfold ahead of the big weekend.
Saturday, September 13, is the centerpiece day featuring a stacked slate of games including high-profile contests. Top-ranked Ohio State looks to extend its dominance as they host in-state rival Ohio University. Meanwhile, Penn State aims to continue its flawless start hosting Villanova, and LSU welcomes Florida in a key SEC showdown. Oregon travels to Northwestern in a Big Ten opener, while Georgia faces a tough road test at Tennessee. Other games to watch include South Florida at Miami, Clemson at Georgia Tech and Oklahoma at Temple.
Week 3 offers teams a chance to solidify their rankings before conference play heats up. Fans can expect a mix of offensive fireworks, defensive battles, and early statements that could define the college football landscape as the season ramps up. The week features widespread TV coverage across ESPN, FOX, Big Ten Network, and ACC Network to deliver all the top matchups and storylines.
College Football Betting Lines
Georgia at Tennessee
Georgia looks to sustain its dominant start, relying on a balanced offense and a stout defense against a Tennessee team fueled by home-field energy. The Volunteers, led by rising QB Joey Aguilar, will try to push Georgia’s limits with an aggressive defensive front and playmaking ability. This rivalry promises physicality and what should be a great finish.
Florida at LSU
Another high-stakes SEC matchup on the same day, Florida travels to LSU fresh off a surprising loss to South Florida last week. Billy Napier’s Gators will aim to rebound and prove they're still contenders in the conference. LSU, coming off a grinding victory against Louisiana Tech, seeks to showcase its defensive strength and efficient offensive execution. This SEC matchup could turn on the intensity of the trenches and turnover battle.
Texas A&M at Notre Dame
The Week 3 showdown between Texas A&M and Notre Dame is a marquee non-conference battle. Both teams are motivated to strengthen their playoff resumes. Notre Dame, coming off an impressive start, seeks to assert dominance at home, while Texas A&M aims to harness their power running game and strong defense to steal a win in South Bend. This game promises intense physicality and strategic chess match coaching as both teams contend for national relevance early in the season.
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What to Watch:
- Georgia’s ability to establish the run against Tennessee’s front. seven.
- Joey Aguilar's passing accuracy and connection with Chris Brazzell II.
- Florida’s defense rebounding and forcing LSU mistakes.
- LSU’s ability to control the line of scrimmage and time of possession.
- Texas A&M’s power running game versus Notre Dame’s defensive front.
- Ability of defensive units to limit explosive plays.
Let’s look at the Week 3 college football schedule and spotlight Georgia at Tennessee, Florida at LSU and Texas A&M at Notre Dame.
2025-2026 College Football Week 3 Schedule
Thursday, September 11, 2025
7:30 p.m. | NC State at Wake Forest | ESPN
Friday, September 12, 2025
6:30 p.m. | Indiana State at Indiana | Big Ten Network
7 p.m. | Colgate at Syracuse | ACC Network
7:30 p.m. | Colorado at Houston | ESPN
9 p.m. | Kansas State at Arizona | FOX
10 p.m. | New Mexico at UCLA | Big Ten Network
Saturday, September 13, 2025
12 p.m. | Oregon at Northwestern | FOX
12 p.m. | Clemson at Georgia Tech
12 p.m. | Central Michigan at Michigan | Big Ten Network
12 p.m. | Oklahoma at Temple | ESPN2
12 p.m. | Wisconsin at Alabama
12 p.m. | Lehigh at Duquesne | ESPN+
12 p.m. | Houston Christian at Nebraska | FS1
12 p.m. | Towson at Maryland | Peacock
12 p.m. | William & Mary at Virginia | ACC Network
12 p.m. | Samford at Baylor | ESPN+
12 p.m. | Memphis at Troy | ESPNU
12 p.m. | Buffalo at Kent State | CBSSN
12:45 p.m. | South Alabama at Auburn | SEC Network
1 p.m. | Davidson at Tennessee Tech | ESPN+
1 p.m. | Lafayette at Georgetown | ESPN+
2 p.m. | New Hampshire at Ball State | ESPN+
2 p.m. | Northern Colorado at South Dakota | ESPN+
2 p.m. | Rhode Island at Holy Cross | ESPN+
2:30 p.m. | Elon at Western Carolina | ESPN+
3 p.m. | UConn at Delaware | ESPN+
3 p.m. | North Dakota at Montana | ESPN+
3 p.m. | San Diego at Montana State | ESPN+
3 p.m. | Illinois State at Eastern Illinois | ESPN+
3 p.m. | Bowie State at Delaware State | ESPN+
3:30 p.m. | Villanova at Penn State | FS1
3:30 p.m. | Georgia at Tennessee | ABC
Georgia is listed as almost a touchdown favorite against the Volunteers on Saturday. The Georgia Bulldogs, undefeated and ranked near the top of the polls, visit Neyland Stadium looking to continue their dominant SEC start. Georgia's balanced offense led by quarterback Gunner Stockton and a stout defense have overwhelmed opponents so far, though they faced a tougher battle in their last game. Tennessee, powered by quarterback Joey Aguilar’s dynamic playmaking and strong home crowd energy, is poised to make the rivalry fiercely competitive. With ESPN’s College GameDay in town, the atmosphere will be electric and both teams know this game can set the tone for their conference championship aspirations.
This matchup promises to be a physical, closely contested showdown where offensive line battles and defensive adjustments will be crucial. Tennessee’s aggressive front seven will test Georgia’s run game and protection schemes, while Georgia’s disciplined defense will aim to contain Aguilar’s scrambling ability and limit big plays. Special teams could play a decisive role in field position in what is likely to be a nail-biter until the final minutes.
3:30 p.m. | SMU at Missouri State | CBSSN
3:30 p.m. | Oregon State at Texas Tech | FOX
3:30 p.m. | USC at Purdue | CBS/Paramount+
3:30 p.m. | Norfolk State at Rutgers | Big Ten Network
3:30 p.m. | Youngstown State at Michigan State | Big Ten Network
3:30 p.m. | Washington State at North Texas | ESPNU
3:30 p.m. | Pitt at West Virginia | ESPN
3:30 p.m. | Richmond at North Carolina | ACC Network
3:30 p.m. | Northwestern State at Cincinnati | ESPN+
3:30 p.m. | UIW at UTSA | ESPN+
3:30 p.m. | Morgan State at Toledo | ESPN+
3:30 p.m. | Southeast Missouri State at North Dakota State | ESPN+
3:30 p.m. | VMI at Bucknell | ESPN+
4 p.m. | Iowa State at Arkansas State | ESPN2
4 p.m. | Louisiana at Missouri | ESPN+/SECN+
4 p.m. | Utah Tech at Idaho | ESPN+
4 p.m. | Lindenwood at Charleston Southern | ESPN+
4:15 p.m. | UTEP at Texas | SEC Network
4:30 p.m. | South Florida at Miami (Fla.) | The CW Network
4:30 p.m. | Alabama A&M at Tennessee State | ESPN+
5 p.m. | Liberty at Bowling Green | ESPN+
5 p.m. | Middle Tennessee at Nevada | Mountain West Network
5 p.m. | Eastern Washington at UNI | ESPN+
6 p.m. | Alcorn State at Mississippi State | ESPN+/SECN+
6 p.m. | FAU at FIU | ESPN+
6 p.m. | Merrimack at Kennesaw State | ESPN+
6 p.m. | Eastern Kentucky at Marshall | ESPN+
6 p.m. | Monmouth at Charlotte | ESPN+
6 p.m. | East Tennessee State at West Georgia | ESPN+
6 p.m. | Bethune-Cookman at South Carolina State | ESPN+
6 p.m. | Fayetteville State at North Carolina Central | ESPN+
6 p.m. | Stetson at Chattanooga | ESPN+
6 p.m. | Wofford at Mercer | ESPN+
6 p.m. | West Liberty at Robert Morris | ESPN+
7 p.m. | Ohio at Ohio State | Peacock
7 p.m. | Western Michigan at Illinois | FS1
7 p.m. | Old Dominion at Virginia Tech | ACC Network
7 p.m. | Jacksonville State at Georgia Southern | ESPN+
7 p.m. | Murray State at Georgia State | ESPN+
7 p.m. | Appalachian State at Southern Miss | ESPN+
7 p.m. | Prairie View A&M at Rice | ESPN+
7 p.m. | Weber State at McNeese | ESPN+
7 p.m. | The Citadel at Gardner-Webb | ESPN+
7 p.m. | Southern Illinois at UT Martin | ESPN+
7 p.m. | Valparaiso at Western Illinois | ESPN+
7 p.m. | Morehead State at Austin Peay | ESPN+
7 p.m. | Northeastern State at North Alabama | ESPN+
7 p.m. | Mississippi Valley State at SE Louisiana | ESPN+
7 p.m. | Arkansas at Ole Miss | ESPN
7 p.m. | Drake at South Dakota State | ESPN+
7 p.m. | Erskine at Presbyterian | ESPN+
7:30 p.m. | Florida at LSU | ABC
The Tigers are laying more than a touchdown at home on Saturday against the Gators. After an unexpected loss last week that will test the Florida Gators’ resilience, they travel to Baton Rouge to face LSU in a pivotal SEC matchup. Florida’s defense has struggled at times this season, and shutting down LSU’s efficient offense led by quarterback Garrett Nussmeier will be vital to getting back on track. LSU, meanwhile, has relied on a tough, physical approach, controlling the clock with a strong running game and an opportunistic defense. This battle could come down to execution in the trenches and turnover margin.
Both teams will be eager to assert dominance as this game could affect their standings in the SEC East. Florida looks to regain confidence and momentum, while LSU hopes to capitalize on home-field advantage and reinforce its status as a conference contender. Expect a gritty, workmanlike game with key adjustments from both coaching staffs influencing the outcome.
7:30 p.m. | Texas A&M at Notre Dame | NBC/Peacock
The Fighting Irish are listed as about a touchdown favorite at home against the Aggies. Texas A&M travels to South Bend to challenge a Notre Dame team that has yet to find consistency at quarterback but boasts a relentless defense and passionate home crowd. The Aggies will seek to dominate with their power running game and physical defensive front, testing Notre Dame’s ability to protect their quarterback and stay disciplined in coverage. Notre Dame, known for its stout defense, will need to pressure the Texas A&M offense while minimizing mistakes on offense to keep pace.
This non-conference marquee matchup is likely to be a clash of styles—Texas A&M’s physicality and ball control against Notre Dame’s defensive toughness and home-field advantage. The game could hinge on which team wins the trench battle and limits explosive plays, making halftime adjustments especially critical as both teams fight for early season momentum and national relevance.
7:30 p.m. | Eastern Michigan at Kentucky | ESPNU
7:30 p.m. | UMass at Iowa | Big Ten Network
7:30 p.m. | New Mexico State at Louisiana Tech | ESPN+
7:30 p.m. | East Carolina at Coastal Carolina | ESPN+
7:45 p.m. | Vanderbilt at South Carolina | SEC Network
8 p.m. | Utah at Wyoming | CBSSN
8 p.m. | Duke at Tulane | ESPN2
8 p.m. | Abilene Christian at TCU | ESPN+
8 p.m. | Navy at Tulsa | ESPN+
8 p.m. | Western Oregon at Cal Poly | ESPN+
8 p.m. | Sul Ross State at Stephen F. Austin | ESPN+
8 p.m. | Langston at UT Rio Grande Valley | ESPN+
8:30 p.m. | Akron at UAB | ESPN+
8:30 p.m. | Northern Arizona at Southern Utah | ESPN+
9:45 p.m. | Air Force at Utah State | FS1
10 p.m. | Southern at Fresno State
10:30 p.m. | Texas State at Arizona State | TNT/truTV/HBO Max
10:30 p.m. | Minnesota at Cal | ESPN
10:30 p.m. | Boston College at Stanford | ACC Network
11:59 p.m. | Portland State at Hawai'i | Spectrum Sports
2025-2026 College Football Schedule
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