2025 Monday Night Football Best Bets - NFL Lines & Picks

2025 NFL Monday Night Football Week 2 Betting Lines

NFL Monday Night Football Betting

The first of four Monday Night Football doubleheaders takes place in Week 2 starting with an interconference matchup between the Tampa Bay Buccaneers and Houston Texans. That game kicks off at 7 p.m. ET from NRG Stadium in Houston and will air on ABC and ESPN. The nightcap features an AFC West clash between Week 1 winners the Los Angeles Chargers and Las Vegas Raiders. The game from Allegiant Stadium in Las Vegas is scheduled to kick off at 10 p.m. ET on ESPN.

Multiple games on Monday night have been a common occurrence in the NFL over the past several years with expanded coverage of the league given to ABC/ESPN through a media rights agreement. I’m not sure many fans will argue having more games on a weeknight, except that the late game will be missed by a large portion of fans in a different time zone. Houston was the only team among the four to lose in Week 1 failing to score a touchdown in a 14-9 loss to the Rams. The Bolts and Raiders each pulled off upset wins last week with LA beating AFC Champion Kansas City in Brazil.

Texans vs. Buccaneers MNF Week 2 Lines

Spread: Texans -3

Total: 42.5

Money Line: Texans -152 / Buccaneers +132

You have to hand it to the Bucs for winning enough games to produce four straight division titles. However, it’s not like they were knocking the socks off opponents. Over the past three seasons they compiled a 27-24 regular season record winning the division in 2022 with a losing record. Led by Baker Mayfield the Bucs had a top 5 offense a season ago. Mayfield completed more than 71 percent of his throws for 4,500 yards and 41 touchdowns. In the season opening win over Atlanta Mayfield had three scoring passes and was not intercepted. He led the NFL with 16 picks in 2024.

The Texans need more offense after settling for three field goals in a Week 1 loss to the Rams. It’s only one game and too early to overreact, but the Texans turned the ball over twice in the second half and failed to score. Changed on the offensive line led to a few disruptions and the unit appeared to have problems grasping the schemes of new offensive coordinator Nick Caley. Houston has won all five meetings since the 2007 season, most recently a 39-37 triumph in 2023 when C.J. Stroud threw for 470 yards and five TDs.

Chargers vs. Raiders MNF Week 2 Lines

Spread: Chargers -3.5

Total: 47

Money Line: Chargers -190 / Raiders +163

The Chargers ended a 7-game losing streak to the Chiefs with their Week 1 win sending a message that the team that won 11 games a season ago is in it for the long haul. Jim Harbaugh took the shackles off opening up the passing game and Justin Herbert delivered throwing for 318 yards and three TDs. The defense allowed 347 total yards but came up big when needed holding the Chiefs to 5 of 14 on third downs and just 1 of 3 in the red zone. The Bolts won outright as a 3-point dog.

Veteran coach Pete Carroll made his Raiders debut a memorable one beating New England 20-13 in the opener. Acquiring Geno Smith looked like a genius move in Week 1 with the veteran QB throwing for 362 yards and a TD. Playing with a hamstring injury in the second half, Smith was 13 of 15 for 222 yards. The club did lose Brock Bowers and Elandon Roberts to injury with the status of both unclear for Monday’s tilt. Those would be a major loss on each side of the football.

The Chargers won and cashed in both games last season outscoring the Raiders 56-30. It was the first season sweep for either side in the last five years.

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2025 Monday Night Football Betting Schedule

WEEK VISITING TEAM HOST TEAM SCORE
Week 1 Minnesota Vikings Chicago Bears 27-24
Week 2 Tampa Bay Buccaneers Houston Texans -
Week 2 Los Angeles Chargers Las Vegas Raiders -
Week 3 Detroit Lions Baltimore Ravens -
Week 4 New York Jets Miami Dolphins -
Week 4 Cincinnati Bengals Denver Broncos -
Week 5 Kansas City Chiefs Jacksonville Jaguars -
Week 6 Buffalo Bills Atlanta Falcons -
Week 6 Chicago Bears Washington Commanders -
Week 7 Tampa Bay Buccaneers Detroit Lions -
Week 7 Houston Texans Seattle Seahawks -
Week 8 Washington Commanders Kansas City Chiefs -
Week 9 Arizona Cardinals Dallas Cowboys -
Week 10 Philadelphia Eagles Green Bay Packers -
Week 11 Dallas Cowboys Las Vegas Raiders -
Week 12 Carolina Panthers San Francisco 49ers -
Week 13 New York Giants New England Patriots -
Week 14 Philadelphia Eagles Los Angeles Chargers -
Week 15 Miami Dolphins Pittsburgh Steelers -
Week 16 San Francisco 49ers Indianapolis Colts -
Week 17 Los Angeles Rams Atlanta Falcons -
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