2025 Thursday Night Football Best Bets - NFL Lines & Picks

2025 NFL Thursday Night Football Week 5 Betting Lines

The Thursday Night Football trip through the NFC West concludes in Week 5 with the other half of the division opening the betting week when the Los Angeles Rams host the San Francisco 49ers. There was a thrilling finish to last week’s game with Seattle getting a walkoff field goal for a 23-20 win over Arizona. The Rams and Niners have combined to win seven of the last eight division titles with each winning a pair since the Seahawks snuck in and claimed the crown in 2020. And the two are favored to continue the trend in 2025.

Despite a rash of early season injuries San Francisco got off to a hot start. With Brock Purdy missing a couple of games Mac Jones stepped in and delivered two victories. It wasn’t easy but the Niners opened with three straight wins by a combined total of 10 points. The Rams take a 3-game series winning streak into the matchup with payouts in the last four. Seven of the last 10 meetings between the rivals were decided by seven points or less.

49ers at Rams TNF Week 5 Lines

Spread: Rams -6.5

Total: 46.5

Money Line: 49ers +253 / Rams -303

49ers at Rams Betting Preview

It looked like the Rams were going to match San Francisco’s 3-0 start and get some revenge for last season’s playoff loss. Instead LA wasted a 26-7 second half lead and fell to the Eagles 33-26. Getting 3.5-points on the closing line it still looked good for LA in the closing seconds. Down by a point they lined up for a potential game-winning field goal only to have the kick blocked and returned for a touchdown allowing the Eagles to not only escape with the W but also cover the line, shocking LA backers.

It was a shocking collapse by the Rams defense, which played so well in the first two weeks of the season. It was a carryover from a season ago when the group dominated in the last month. During a late season stretch the Rams held three consecutive opponents to less than 10 points, one of which was the Niners. That allowed the Rams to win double digit games for the sixth time in coach Sean McVay’s eight seasons and get the division crown.

The Rams are relying on a young defense that entered Week 4 ranked fifth in yards allowed and tied for second in sacks. And savvy veteran Matthew Stafford hasn’t been too shabby leading the offense. The Rams were fifth in the league in total offense and Puka Nacua came into Week 4 leading the NFL with 29 receptions.

While most of San Francisco’s early season injuries are minor with players expected to miss a few games at most, the Niners did get hit with a major setback in their Week 3 win over Arizona. Former Defensive Player of the Year Nick Bosa was lost for the season with a knee injury taking the most feared pass rusher in the game off the field. Bosa had 2.0 sacks, 4 TFLs and forced a pair of fumbles in the first three weeks. “Losing Nick is a big deal,” Fred Warner said.

The rivalry is a natural given their geographical proximity. And it’s become more intense in recent years with both clubs enjoying success on the field. There were some dull moments when the Rams relocated to St. Louis in the mid-1990s and the Niners bridged the move by winning 17 consecutive games. LA’s current winning streak is its longest in the series since winning six in a row in the early 2000’s. The Rams snapped a five-game regular season home losing streak with their 27-24 win last year. Their lone win prior to that was in the NFC Championship game for the 2021 season that allowed LA to win the Super Bowl.

Ready to Bet on the NFL?

Bet 2025 NFL odds at BookMaker—spread bets, totals, player props, and futures all season long.

* Trusted by sharp bettors for over 30 years

* Early odds, fast payouts, and Bitcoin betting

* Live betting and mobile-optimized sportsbook

* Don’t just watch the action — bet on it!

* Sign Up Now and lock in your NFL picks today!

2025 Thursday Night Football Schedule

Did You Know?

At BookMaker, we go beyond just providing top-notch sports betting options! Take advantage of these exclusive features and rewards:

BookMaker ATM Card for seamless transactions: Easily access your funds with the BookMaker ATM card, providing instant access to your winnings and secure transactions wherever you go.

Loyalty Levels & BetPoints Programs for additional rewards: Earn BetPoints as you bet, and unlock exciting perks at higher loyalty levels. The more you play, the more you earn!

Seasonal and Reload Bonuses to maximize your earnings: Stay ahead with seasonal promotions and reload bonuses, boosting your bankroll throughout the year.

Early Cashout Option for added flexibility: Cash out your bet early and lock in profits or limit losses—putting you in control of your wagers.

Free Crypto Payouts for fast and secure withdrawals: Enjoy fast, secure withdrawals with zero fees when you choose crypto payouts.

Open Play Option for unique parlay betting: Get creative with your parlays using the Open Play option, offering more ways to win.

Casino Promotions & Contests for extra fun and wins: Join in on exclusive casino promotions and contests, adding excitement to your betting experience.

8% Cash Back on all your horse racing bets: Place horse racing bets and get 8% cash back on your losses, making it easier to bounce back.

Explore all these benefits and more at BookMaker!

Betting Rules & Policies

Free Play Rules

• Free plays cannot be used on proposition bets.
• Free Plays do not earn any BetPoints™
• Bets made using Free Plays do not count towards completing any rollovers. (Free Plays are always subject to a rollover of their own. You must complete the required rollover prior to making a withdrawal).
• The maximum payout for any Free Play is $5,000.
• Free Plays that are left unused for 180 days will be removed from your account.

ROLLOVER

• Did you know that on all deposits made at BookMaker, there is a rollover requirement: an amount of betting action you must fulfill before you are eligible to make a withdrawal.

• Did you know that rollovers are calculated by multiplying the amount initially credited to your account a certain number of times? Yes! If you deposit without claiming any bonus, the rollover will always be 1x (one-time) your deposit amount. If you do claim a deposit bonus, the rollover will be higher and is based on the deposit plus bonus amount.

Wager disputes (claims)

If you disagree with any aspect of a wager you’ve placed, you are welcome to log an official dispute (commonly known as a “claim”). Claims must be reported no later than 15 (fifteen) calendar days following the settlement of the wager.

If following an initial review of the case there remains any doubt regarding the wager type, line, market, amount, or any other detail, the claim will be escalated to the BookMaker management team. All decisions made by them are final.

Wager Cash Out - How it works

With the Cash Out feature you can choose to eliminate a wager that's already been placed, and receive back either a portion, or your full stake amount.

Cash Out is selectively available on certain events, fixtures, and markets.

In order to see if a wager is eligible to be cashed out, simply navigate to your Bet Slip and check the 'My Open Bets' tab. If eligible, the Cash Out button will be displayed.

It’s also important to note that Cash Out is not contributing to any bonus or promotion including Bet Point accumulation and Rollover for releasing bonus cash.