2025 Louisville Cardinals College Football Betting Online

2025 Louisville Cardinals CFB Betting Lines

So far, it has been a successful homecoming for Louisville head coach Jeff Brohm. Brohm, the favorite native son and Louisville alum and former starting quarterback for the Cardinals, led The Ville to the ACC championship game and a 10-4 record, with a final national ranking of 19th, in his debut season of 2023. In 2024, Brohm delivered a 9-4 record and Sun Bowl win. Indeed, Louisville fans are excited about the future following Brohm's impressive success.

If anyone doubts Brohm, they should look at his previous stops at Western Kentucky and Purdue. Brohm was 30-10 at WKU and led the Hilltoppers to a final ranking of 24th in 2015. At Purdue, he went 36-34, including 9-4 and 8-5 in his final two years. Purdue went to four bowl games in six seasons under Brohm and made the 2022 Big Ten championship game. For Purdue, that is as good as it can get.

College Football Betting Lines

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2025 Louisville Cardinals Preview

Louisville will have more talent and experience in Year 3 under coach Jeff Brohm. The returning players are more comfortable in his system, while the newcomers bring more talent to a team coming off consecutive bowl campaigns. The Cardinals appear to have what it takes to make the conference title game again this season.

Assuming Florida State will be better, it’s obviously a team to miss. Not having to play NC State this year will be good, not dealing with Georgia Tech is great, and not getting Syracuse isn’t a bad thing. Not facing Duke, Stanford, and Wake Forest is a rough break, though.

James Madison is hardly a tap-in, but the first three games against Group of Five programs. Virginia, Boston College, and Cal should all be able to secure home dates to reach six wins and bowl eligibility without too much of an issue. There’s a week off before going to Miami, and if SMU isn’t nearly as strong as it was last year, the last two road games against the Mustangs and Virginia Tech are winnable. It helps that Kentucky has to come over to play.

Louisville might be a bit of a sleeper with this schedule. Seriously, we all respect Pitt, and SMU did some fine work last year, but the road games aren’t totally horrible. Be made if the home record isn’t at least 6-1 going into the Kentucky game, and even with a misfire along the way, 10-2 isn’t asking for the world, even if the final record is more like 9-3.

2025 Louisville Cardinals Football Schedule

Nearly all the success enjoyed by the Louisville football program has taken place in the last two decades. Since 1998, the Cardinals have appeared in 16 of the program’s 21 bowl games, and they’ve had just two losing seasons in that span. The Cards have also been a member of four conferences in that stretch, but appear to have found a home in the ACC.

The Cardinals made their first bowl game a success by beating Drake in the Sun Bowl following the 1957 season. It would be 13 more seasons before the Cards returned to a bowl and 33 more before they notched another win. The Cards had their first 10-win season and won the Fiesta Bowl in 1999.

Coach John L. Smith began to transform the program into a national powerhouse in the late 1990s, stringing together five consecutive winning seasons and bowl games, leaving the club in good shape for Bobby Petrino’s first stint. The Cards won 41 games in four years and earned their highest ranking ever in the AP poll, reaching a peak of No. 3. Following a program record 12 wins and an Orange Bowl victory in 2006, Petrino left for the NFL. Petrino returned in 2014, and the Cards won at least eight games in each of his four seasons. Lamar Jackson won a Heisman Trophy under Petrino in 2016.

After a 2018 collapse, Petrino was fired, and Scott Satterfield struggled to break out. After Satterfield fled to Cincinnati one step ahead of the posse, Louisville found the perfect fit in native son Jeff Brohm.

2025-2026 College Football Schedule

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