College Football Week 7 Best Bets - Football Lines
Week 7 of the 2025 college football season delivers more outstanding matchups with College Football Playoff implications.
As the midway point of the college football season approaches, the pretenders and contenders are being separated. The Penn State Nittany Lions and Texas Longhorns are prime examples of pretenders.
Last week, Penn State was utterly humiliated in a 42-37 loss to the putrid UCLA Bruins as 25-point road favorites. It was one of the most embarrassing losses in the proud history of Penn State and certainly in the head coach James Franklin era. This week, Penn State hosts the Northwestern Wildcats.
Meanwhile, the Texas Longhorns flopped at Florida in a 29-21 loss to the Gators as 4.5-point road favorites. The Gators were far more dominant than the final score indicated.
Quarterback Arch Manning often appears lost, but the Longhorns' offensive line is not providing much protection, making the process even more challenging. Texas opened the season as the top-ranked team in college football and now appears to be a program that will likely miss the College Football Playoff.
Texas meets the Oklahoma Sooners this week in the Red River Shootout, desperately needing a win over its hated and undefeated arch-rival.
As a result of their flops, Texas and Penn State have been laughed out of the AP Top 25 rankings.
Gamblers and fans will be focusing on some prime Week 7 matchups, such as the #1 Ohio State Buckeyes at the #17 Illinois Fighting Illini, the #7 Indiana Hoosiers at the #3 Oregon Ducks, the #15 Michigan Wolverines at the USC Trojans, the #8 Alabama Crimson Tide at the #14 Missouri Tigers, and the Red River Shootout matchup between the #6 Sooners and the Longhorns.
College Football Betting Lines
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2025-2026 College Football Week 7 Schedule
Wednesday, October 8, 2025
7:30 p.m. | Missouri State at Middle Tennessee | ESPN2
8 p.m. | Liberty at UTEP | CBSSN
Thursday, October 9, 2025
7 p.m. | Louisiana Tech at Kennesaw State | ESPNU
7:30 p.m. | East Carolina at Tulane | ESPN
8 p.m. | Jacksonville State at Sam Houston | CBSSN
8 p.m. | Southern Miss at Georgia Southern | ESPN2
Friday, October 10, 2025
7:30 p.m. | South Florida at North Texas | ESPN2
9 p.m. | Rutgers at Washington | FS1
9 p.m. | Fresno State at Colorado State | CBSSN
Saturday, October 11, 2025
12 p.m. | Ohio State at Illinois | FOX
12 p.m. | Alabama at Missouri | ABC
The Missouri Tigers will host the Alabama Crimson Tide at Faurot Field in Columbia, MO. Kickoff time is Noon ET with television coverage on ABC. The game opened with Alabama as a relatively small 4.5-point road favorite. The betting line shows respect for a quality Mizzou program that is dangerous at home.
Since its Week 1 stink bomb loss at Florida State, the Crimson Tide has ripped off four consecutive wins. Last week, Alabama routed a good Vanderbilt team 30-14 as 11.5-point home favorites. The Crimson Tide is 4-1 straight up and against the spread and 3-2 over the total.
Mizzou is coming off a bye week that followed a 42-6 home win over the UMass Minutemen as 44.5-point overlays. Missouri is 5-0 straight up, 3-2 against the spread, and 4-1 over the total. Head coach Eli Drinkwitz is likely to have some tricks up his sleeve with the extra week of prep time.
12 p.m. | Pitt at Florida State | ESPN
12 p.m. | UCLA at Michigan State | Big Ten Network
12 p.m. | Stanford at SMU | The CW Network
12 p.m. | UCF at Cincinnati | FS1
12 p.m. | Houston at Oklahoma State | TNT/HBO Max
12 p.m. | Louisiana at James Madison | ESPN2
12 p.m. | Charlotte at Army | CBSSN
12 p.m. | Miami (Ohio) at Akron | ESPN+
12 p.m. | Toledo at Bowling Green | ESPNU
12:45 p.m. | Washington State at Ole Miss | SEC Network
1 p.m. | Northern Illinois at Eastern Michigan | ESPN+
2:30 p.m. | UMass at Kent State | ESPN+
3:30 p.m. | Indiana at Oregon | CBS
The Oregon Ducks will host the Indiana Hoosiers at Autzen Stadium in Eugene, OR. Kickoff time is 3:30 p.m. ET with television coverage on CBS. This matchup is for the top of the Big Ten Conference.
Indiana is coming off a bye week that followed a gritty 20-15 win at Iowa as 9-point road favorites. The Hoosiers are 5-0 straight up, 3-2 against the spread, and 3-2 over the total. Indiana ranks 4th in the nation for scoring offense and 3rd for fewest points allowed.
The Oregon Ducks are also coming off a bye that followed a 30-24 overtime win at Penn State as 3.5-point road dogs. Oregon is 5-0 straight up, 3-1-1 against the spread, and 3-2 over the total. Oregon ranks 7th for scoring offense and 6th for fewest points allowed.
3:30 p.m. | Oklahoma vs. Texas (in Dallas) | ABC
3:30 p.m. | Northwestern at Penn State | FS1
3:30 p.m. | Iowa State at Colorado | ESPN
3:30 p.m. | Virginia Tech at Georgia Tech | ACC Network
3:30 p.m. | NC State at Notre Dame | Peacock
3:30 p.m. | Nebraska at Maryland | Big Ten Network
3:30 p.m. | Wake Forest at Oregon State | The CW Network
3:30 p.m. | TCU at Kansas State | FOX
3:30 p.m. | Air Force at UNLV | CBSSN
3:30 p.m. | Appalachian State at Georgia State | ESPN+
3:30 p.m. | Old Dominion at Marshall | ESPN+
3:30 p.m. | Ball State at Western Michigan | ESPN+
4 p.m. | Navy at Temple | ESPN2
4:15 p.m. | Arkansas at Tennessee | SEC Network
6 p.m. | UAB at Florida Atlantic | ESPN+
7 p.m. | Florida at Texas A&M | ESPN
7 p.m. | Iowa at Wisconsin | FS1
7 p.m. | San Jose State at Wyoming | CBSSN
7 p.m. | UL Monroe at Coastal Carolina | ESPN+
7:30 p.m. | Georgia at Auburn | ABC
7:30 p.m. | Kansas at Texas Tech | FOX
7:30 p.m. | Michigan at USC | NBC
The USC Trojans will host the Michigan Wolverines at the LA Memorial Coliseum in Los Angeles, CA. The kickoff time is 7:30 p.m. ET, with television coverage on NBC.
Once upon a time, a matchup between the Michigan Wolverines and USC Trojans would be in the Rose Bowl. However, the advent of the College Football Playoff and conference realignment has altered those dynamics.
Since their Week 2 loss at Oklahoma, the Wolverines have won three consecutive games. Michigan is 4-1 straight up, 2-3 against the spread, and 3-2 over the total.
The USC Trojans are coming off a bye week that followed a 34-32 loss at Illinois in the final seconds. USC is 4-1 straight up, 2-3 against the spread, and 4-1 over the total.
7:30 p.m. | Purdue at Minnesota | Big Ten Network
7:30 p.m. | Clemson at Boston College | ACC Network
7:30 p.m. | Rice at UTSA | ESPNU
7:45 p.m. | South Carolina at LSU | SECN
8 p.m. | BYU at Arizona | ESPN2
8 p.m. | Troy at Texas State | ESPN+
9:45 p.m. | New Mexico at Boise State | FS1
10:15 p.m. | Arizona State at Utah | ESPN
10:30 p.m. | San Diego State at Nevada | CBSSN
11:59 p.m. | Utah State at Hawai'i | Spectrum Sports
2025-2026 College Football Schedule
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