College Football Week 4 Best Bets - Football Lines
Week 4 of the 2025 college football season arrives with several marquee matchups that will significantly impact the College Football Playoff race and conference standings. The weekend kicks off Thursday with Rice at Charlotte on ESPN and Friday features Iowa traveling to Rutgers in Big Ten action on FOX, while Oklahoma State hosts Tulsa on ESPN. Saturday's slate is headlined by several key conference openers and rivalry games, including No. 17 Texas Tech visiting No. 16 Utah in a ranked Big 12 showdown on FOX's Big Noon Saturday. Other notable games include No. 9 Illinois at No. 19 Indiana in prime time on NBC for both teams' Big Ten opener, and No. 22 Auburn traveling to No. 11 Oklahoma in what promises to be a compelling SEC matchup featuring Auburn quarterback Jackson Arnold facing his former team.
The weekend also features several intriguing non-conference battles and early conference tests that could reshape the playoff picture. Florida travels to No. 4 Miami in an ACC-SEC clash that could determine momentum in both programs' seasons, while No. 21 Michigan visits Nebraska in a Big Ten matchup between programs looking to establish their credentials. Oregon State faces its former Pac-12 rival No. 6 Oregon in what will be an emotional reunion, and Washington takes on Washington State in the Apple Cup. With conference play ramping up across the Power Four leagues, Week 4 serves as a crucial juncture where contenders will begin to separate from pretenders, setting the stage for what promises to be an intense stretch run toward the expanded 12-team College Football Playoff.
Week 4 doesn’t feature a lot of matchups between ranked teams but the schedule still has some excellent matchup as conference play gets started for a number of teams. Fans can expect a mix of offensive fireworks, defensive battles, and early statements that could define the college football landscape as the season ramps up. The week features widespread TV coverage across ESPN, NBC, FOX, Big Ten Network, and ACC Network to deliver all the top matchups and storylines.
College Football Betting Lines
Texas Tech at Utah
No. 17 Texas Tech travels to Salt Lake City for a Big 12 Conference opener against No. 16 Utah in FOX's Big Noon Saturday showcase at Rice-Eccles Stadium. Both teams enter 3-0 with explosive offenses, as the Red Raiders are averaging 64.5 points per game while the Utes have scored 106 points through three games. Texas Tech quarterback Behren Morton has thrown for 11 touchdowns without an interception through three games, leading an offense that ranks third nationally in total yards, while Utah's Devon Dampier has guided the Utes to dominant wins over UCLA, Cal Poly, and Wyoming. The winner will notch its first victory over a ranked opponent this season and gain early momentum in Big 12 play.
Auburn at Oklahoma
No. 22 Auburn travels to Norman for a heavyweight SEC showdown against No. 11 Oklahoma on Saturday afternoon, featuring a compelling storyline as Tigers quarterback Jackson Arnold returns to face his former team. Arnold, who transferred from Oklahoma after starting 10 games last season, has led Auburn to a 3-0 start with seven total touchdowns while committing zero turnovers. The Sooners counter with their own transfer quarterback in John Mateer from Washington State, who has thrown for 944 yards and seven touchdowns through three games while ranking second nationally in total offense. This marks Oklahoma's first SEC home game and Auburn's first conference road test, with both teams looking to make an early statement in league play.
Illinois at Indiana
No. 9 Illinois travels to Bloomington for a prime-time Big Ten Conference opener against No. 19 Indiana on Saturday night in what promises to be a marquee matchup with College Football Playoff implications. Both teams enter 3-0 with impressive offensive performances, as the Fighting Illini have outscored opponents 128-9 through three games while the Hoosiers completed non-conference play with a dominant 73-0 victory over Indiana State. Illinois quarterback Luke Altmyer returns for his third season in Champaign after throwing for 22 touchdowns last year, while Indiana's Fernando Mendoza has quickly found his rhythm with the Hoosiers after transferring from Cal. The game marks Indiana's first major test under second-year coach Curt Cignetti, with the sold-out Memorial Stadium crowd set to witness a red-out atmosphere.
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2025-2026 College Football Week 4 Schedule
Thursday, September 18, 2025
7:30 p.m. | Rice at Charlotte | ESPN
Friday, September 19, 2025
6 p.m. | Columbia at Lafayette | ESPN+
7:30 p.m. | Tulsa at Oklahoma State | ESPN
8 p.m. | Iowa at Rutgers | FOX
Saturday, September 20, 2025
12 p.m. | Syracuse at Clemson | ESPN
12 p.m. | Maryland at Wisconsin | NBC
12 p.m. | South Carolina State at South Florida | ESPN+
12 p.m. | Texas Tech at Utah | FOX
No. 17 Texas Tech brings a high-powered offense to Salt Lake City for a pivotal Big 12 Conference opener against No. 16 Utah on Saturday at Rice-Eccles Stadium. The Red Raiders enter 3-0 after dominating victories over Arkansas-Pine Bluff (67-7), Kent State (62-14), and Oregon State (45-14), with quarterback Behren Morton throwing for 11 touchdowns without an interception. Texas Tech ranks third nationally in total offense at 604.5 yards per game and has scored at least 60 points in each of its first two contests. Coach Joey McGuire's squad invested heavily in the transfer portal and features a balanced attack led by Morton, who threw for a career-high 464 yards against Oregon State, and a three-headed rushing attack of Adam Hill, J'Koby Williams, and Cameron Dickey.
Utah matches the Red Raiders' 3-0 record after completing non-conference play with wins over UCLA (43-10), Cal Poly (63-9), and Wyoming (31-6). The Utes are led by transfer quarterback Devon Dampier, who combined for over 300 yards rushing and passing in the Wyoming victory, and feature a balanced ground game with Wayshawn Parker and NaQuari Rogers. Utah's defense has been equally impressive, allowing just 19 points through three games and forcing five turnovers while maintaining a perfect turnover margin. This marks the third all-time meeting between the programs, with Texas Tech holding a 2-0 advantage from wins in 1972 (45-2) and 1973 (29-22). The game will be featured on FOX's Big Noon Kickoff pregame show, with former Utah coach Urban Meyer making an appearance.
12 p.m. | Arkansas at Memphis | ABC
12 p.m. | Wofford at Virginia Tech | ESPN+/ACC Extra
12 p.m. | SMU at TCU | ESPN 2
12 p.m. | Bowling Green at Louisville | ACC Network
12 p.m. | UNLV at Miami (Ohio) | ESPNU
12 p.m. | North Texas at Army | CBSSN
12:45 p.m. | UAB at Tennessee | SEC Network
1 p.m. | Wagner at Central Michigan | ESPN+
3:00 p.m. | Oregon State at Oregon | Big Ten Network
3:30 p.m. | Purdue at Notre Dame | NBC/Peacock
3:30 p.m. | Kent State at Florida State | ACC Network
3:30 p.m. | Auburn at Oklahoma | ABC
No. 22 Auburn brings a 3-0 record to Norman for an SEC clash against No. 11 Oklahoma, headlined by the return of Tigers quarterback Jackson Arnold to face his former team. Arnold transferred from Oklahoma after starting 10 games in 2024 and has rejuvenated his career under coach Hugh Freeze, throwing for four touchdowns and rushing for three more while maintaining a perfect turnover record through three games. The Tigers have shown balance with 195 rushing yards and solid defense in their 31-15 victory over South Alabama last week, with running back Jeremiah Cobb providing a reliable ground game with 119 yards against the Jaguars. Auburn enters ranked in the AP Top 25 for the first time since 2021 and looks to continue their early-season momentum in their SEC opener.
Oklahoma matches Auburn's 3-0 record behind the explosive play of transfer quarterback John Mateer, who has taken the Sooners by storm after arriving from Washington State with offensive coordinator Ben Arbuckle. Mateer set the school record for passing yards in a debut with 392 against Illinois State and followed with strong performances against Michigan (270 passing, 74 rushing) and Temple (282 passing, 51-yard rushing touchdown). The Sooners have transformed their offense from 97th in scoring last season to a dynamic unit averaging 33.7 points per game, while their defense under coach Brent Venables has allowed just 19 points through three contests. Oklahoma won this matchup 27-21 last season with a fourth-quarter comeback, and the Sooners will look to use their home-field advantage at Gaylord Family Oklahoma Memorial Stadium to hand Arnold and Auburn their first loss of the season.
3:30 p.m. | Tulane at Ole Miss | ESPN
3:30 p.m. | Michigan at Nebraska | CBS/Paramount+
3:30 p.m. | North Carolina at UCF | FOX
3:30 p.m. | Ball State at UConn | CBSSN
3:30 p.m. | James Madison at Liberty | ESPNU
3:30 p.m. | Louisiana at Eastern Michigan | ESPN+
3:30 p.m. | Troy at Buffalo | ESPN+
3:30 p.m. | Toledo at Western Michigan | ESPN+
3:30 p.m. | Gardner-Webb at Ohio | ESPN+
4 p.m. | NC State at Duke | ESPN2
4:15 p.m. | Northern Illinois at Mississippi State | SEC Network
4:30 p.m. | Temple at Georgia Tech | The CW Network
5 p.m. | Idaho at San Jose State | TBA
6 p.m. | Delaware at FIU | ESPN+
6 p.m. | Arkansas State at Kennesaw State | ESPN+
6 p.m. | West Virginia at Kansas | FS1
6 p.m. | Duquesne at Akron | ESPN+
7 p.m. | Murray State at Jacksonville State | ESPN+
7 p.m. | Marshall at Middle Tennessee | ESPN+
7 p.m. | UT Martin at Missouri State | ESPN+
7 p.m. | Nevada at Western Kentucky | ESPN+
7 p.m. | Boise State at Air Force | CBSSN
7 p.m. | Maine at Georgia Southern | ESPN+
7 p.m. | Coastal Carolina at South Alabama | ESPN+
7 p.m. | South Carolina at Missouri | ESPN
7:30 p.m. | Georgia State at Vanderbilt | ESPNU
7:30 p.m. | Washington at Washington State | CBS
7:30 p.m. | Stanford at Virginia | ACC Network
7:30 p.m. | BYU at East Carolina | ESPN2
7:30 p.m. | Southern Miss at Louisiana Tech | ESPN+
7:30 p.m. | Florida at Miami (Fla.) | ABC
7:30 p.m. | Illinois at Indiana | NBC
No. 9 Illinois brings a perfect 3-0 record to Bloomington for a Big Ten Conference opener against No. 19 Indiana, with both teams riding high after impressive non-conference campaigns. The Fighting Illini have been dominant under coach Bret Bielema, outscoring Western Illinois (52-3), Duke (38-21), and Western Michigan (38-0) while showcasing a balanced attack led by senior quarterback Luke Altmyer. The former Ole Miss transfer completed his return to form last season with 22 touchdown passes and has continued that momentum in 2025, establishing himself as one of the league's top quarterbacks with 16 starters returning from a 10-win season. Illinois enters as one of the popular picks to make the College Football Playoff for the first time, with their schedule setting up favorably for a deep conference run.
Indiana matches the Fighting Illini's 3-0 record after completing a perfect non-conference slate under second-year coach Curt Cignetti, capped by Friday's historic 73-0 demolition of Indiana State. The Hoosiers set program records with their largest shutout victory since 1901, led by quarterback Fernando Mendoza's near-perfect performance (19-of-20, 270 yards, five touchdowns) and receiver Omar Cooper Jr.'s record-tying four touchdown catches. Cignetti has transformed Indiana football with his first 10-0 start in program history last season, bringing 13 key transfers from James Madison and establishing a championship culture. The prime-time showdown at Memorial Stadium represents Indiana's first major test of the season, with the sold-out crowd creating a red-out atmosphere as both programs look to establish early momentum in what could be a pivotal Big Ten race. Illinois holds a 46-26-2 edge in the all-time series, but Indiana won the last meeting in Bloomington with a 23-20 victory in 2022.
7:30 p.m. | Arizona State at Baylor | FOX
7:45 p.m. | SE Louisiana at LSU | SEC Network
8 p.m. | McNeese at Utah State
8 p.m. | Sam Houston at Texas | ESPN+/SECN+
8 p.m. | Nicholls at Texas State | ESPN+
9 p.m. | UL Monroe at UTEP | ESPN+
9:30 p.m. | UTSA at Colorado State | FS1
10:15 p.m. | Wyoming at Colorado | ESPN
10:30 p.m. | Cal at San Diego State | CBSSN
11 p.m. | Michigan State at USC | FOX
11:59 p.m. | Fresno State at Hawai'i | Spectrum Sports
2025-2026 College Football Schedule
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