College Football Week 2 Best Bets - Football Lines
As the season moves into its second weekend, the energy from a wild Week 1 gives way to another round of statement opportunities. For contenders, Week 2 is less about introductions and more about confirmation. Playoff hopefuls look to reinforce their legitimacy, while others face early crossroads. Rivalries, non-conference showdowns, and the grind of conference play all converge to set the tone for September.
This week’s slate features several top-25 matchups that will test balance, depth, and composure. From historic rivalries to SEC newcomers facing stiff challenges, the results will ripple through playoff conversations long before October arrives.
College Football Betting Lines
Michigan at Oklahoma
A marquee non-conference clash between two top 20 teams pits Michigan’s physical Big Ten identity against Oklahoma’s speed and explosiveness. Michigan wants to control the line of scrimmage and set a bruising tempo, while Oklahoma’s quick-strike offense seeks to stretch the field and put pressure on Michigan’s secondary. This early test will measure both sides’ playoff potential and set the tone for their respective conference runs.
Iowa vs. Iowa State (Cy-Hawk Rivalry)
One of the sport’s most heated in-state battles arrives early. Iowa enters with a renewed passing game and the physical defense it’s known for, while Iowa State counters with toughness and a home-field edge. The Cy-Hawk trophy always carries weight, but in an expanded playoff era, the winner earns more than bragging rights—it gains a meaningful resume boost.
Baylor at SMU
Texas pride takes center stage as Baylor visits SMU in a high-profile Lone Star clash. Baylor aims to assert itself with power football and defensive discipline, while SMU brings speed and a balanced attack. With both programs seeking an early statement, this matchup offers a chance to claim momentum in a crowded state landscape.
Ole Miss at Kentucky
Ole Miss looks to build on an impressive opener by taking its confidence on the road into SEC play. Kentucky brings toughness in the trenches and a disruptive defense, but Ole Miss’s offensive rhythm and tempo could prove decisive. It’s an early SEC test that will reveal whether Ole Miss is ready to contend nationally.
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What to Watch:
- Michigan’s offensive line against Oklahoma’s quick-strike defense.
- Iowa’s developing passing game under pressure in a hostile rivalry atmosphere.
- Texas bragging rights at stake in Baylor–SMU, with long-term implications in recruiting and reputation.
- Ole Miss’s ability to carry early momentum into a difficult SEC road environment.
Let’s look at the Week 2 college football schedule and spotlight Michigan at Oklahoma, Iowa vs. Iowa State, Baylor at SMU and Mississippi at Kentucky.
2025-2026 College Football Week 2 Schedule
Friday, September 5, 2025
7 p.m. | James Madison at Louisville | ESPN2
7:30 p.m. | Northern Illinois at Maryland | Big Ten Network
7:30 p.m. | Western Illinois at Northwestern | Big Ten Network
9 p.m. | Eastern Washington at Boise State | Fox Sports 1
Saturday, September 6, 2025
12 p.m. | Kent State at Texas Tech | TNT/Max
12 p.m. | San Jose State at Texas | ABC or ESPN
12 p.m. | Iowa at Iowa State | FOX
The Cyclones are listed as a 3-point home favorite in NCAA football odds. The annual Cy-Hawk rivalry always carries weight, and this season it doubles as an early measuring stick. Iowa turns to Mark Gronowski at quarterback, hoping his dual-threat ability can spark an offense that’s lacked balance in recent years. The Hawkeyes’ defense remains their strength, but consistency on offense is the storyline to watch. In Week 1, the passing game showed flashes but still looked uneven.
Iowa State enters with its usual physical style and rugged defense, built to thrive in tight, grind-it-out games. Their opener showed discipline and toughness, which they’ll need to frustrate Gronowski. This rivalry often comes down to turnovers and special teams, and this year should be no different.
12 p.m. | Illinois at Duke | ABC or ESPN
12 p.m. | Liberty at Jacksonville State | CBSSN
12 p.m. | East Texas A&M at Florida State | ACC Network
12 p.m. | Baylor at SMU | The CW Network
SMU is listed as a small home favorite in this contest. Baylor looks to steady itself with quarterback Sawyer Robertson leading the offense and a defense capable of creating disruption. The Bears will want to control the pace and keep the game from becoming a shootout. In Week 1, they struggled to find rhythm in the passing game, something that can’t happen again against a more explosive opponent.
SMU brings balance on offense and speed across its skill positions. At home, the Mustangs will try to dictate tempo and stretch Baylor vertically. They opened the season strong, flashing the firepower that could give them the edge in this Lone Star showdown.
12 p.m. | Virginia at NC State | ESPN2
12 p.m. | FIU at Penn State | Big Ten Network
12 p.m. | Kennesaw State at Indiana | FS1
12 p.m. | Northwestern State at Minnesota | Big Ten Network
12 p.m. | Central Michigan at Pitt | ESPNU
12 p.m. | UConn at Syracuse | ESPN+/ACC Extra
12 p.m. | Sacred Heart at Lehigh | ESPN+
12 p.m. | Thomas More at Dayton | TBD TV
12 p.m. | Lincoln (PA) at Duquesne | NEC Front Row
12 p.m. | New Haven at Mercyhurst | NEC Front Row
12:45 p.m. | Utah State at Texas A&M | SEC Network
1 p.m. | Wagner at Georgetown | ESPN+
1 p.m. | Lafayette at Stonehill | NEC Front Row
1 p.m. | Truman State at Butler | TBD TV
1 p.m. | Eastern Illinois at Indiana State | ESPN+
1 p.m. | Bucknell at Marist | ESPN+
1 p.m. | UAlbany at Delaware State | ESPN+
1:30 p.m. | Ferrum College at VMI | ESPN+
2 p.m. | Western Carolina at Wake Forest | ESPN+/ACC Extra
2 p.m. | Howard at Temple | ESPN+
2 p.m. | Presbyterian at Furman | ESPN+
2 p.m. | Robert Morris at Youngstown State | ESPN+
2:30 p.m. | Chattanooga at Tennessee Tech | ESPN+
2:30p.m. | North Dakota State at Tennessee State | ESPN+
3 p.m. | Idaho State at New Mexico | Mountain West Network
3:30 p.m. | Troy at Clemson | ACC Network
3:30 p.m. | Ole Miss at Kentucky | ABC
Mississippi is laying more than a touchdown on the road in this contest. Ole Miss hits the road for its SEC opener with Austin Simmons running the offense. Surrounded by a deep set of weapons, Simmons has the ability to push tempo and spread the field. The Rebels’ defense will also be tested against a power-running attack. In Week 1, Simmons bounced back from an early mistake to post big numbers, a confidence-builder heading into this challenge.
Kentucky leans on a physical offensive line and a defense that can grind opponents down. They’ll want to slow the pace and keep Ole Miss from finding rhythm. Last week, the Wildcats pulled out a win behind strong line play, but questions remain in the passing game. This matchup is a test of tempo versus control in early SEC play.
3:30 p.m. | Saint Francis (PA) at Buffalo | ESPN+
3:30 p.m. | Oklahoma State at Oregon | CBS/Paramount+
3:30 p.m. | Kansas at Missouri | ESPN2
3:30 p.m. | Fresno State at Oregon State | The CW Network
3:30 p.m. | Austin Peay at Georgia | ESPN+/SEC Network+
3:30 p.m. | UAB at Navy | CBSSN
3:30 p.m. | Bryant at UMass | ESPN+
3:30 p.m. | Lindenwood at Appalachian State | ESPN+
3:30 p.m. | Bowling Green at Cincinnati | ESPN+
3:30 p.m. | Miami (Ohio) at Rutgers | Peacock
3:30 p.m. | Grambling at Ohio State | Big Ten Network
3:30 p.m. | Delaware at Colorado | FOX
3:30 p.m. | North Texas at Western Michigan | ESPN+
3:30 p.m. | ETSU at Tennessee | ESPN+/SEC Network+
3:30 p.m. | Gardner-Webb at Georgia Tech | ESPN+/ACC Extra
3:30 p.m. | Texas State at UTSA | ESPN+
3:30 p.m. | The Citadel at Samford | ESPN+
4 p.m. | West Virginia at Ohio | ESPNU
4 p.m. | Middle Tennessee State at Wisconsin | FS1
4 p.m. | St. Thomas at Idaho | ESPN+
4 p.m. | UNI at Wyoming | Altitude Sports
4:15 p.m. | South Florida at Florida | SEC Network
5 p.m. | Sacramento State at Nevada | TBD TV
5 p.m. | Jackson State at Southern Miss | ESPN+
5 p.m. | Arkansas State at Arkansas | ESPN+SEC Network+
5 p.m. | Utah Tech at Northern Arizona | ESPN+
6 p.m. | North Carolina Central at Old Dominion | ESPN+
6 p.m. | Campbell at East Carolina | ESPN+
6 p.m. | Cal Poly at Utah | ESPN+
6 p.m. | Missouri State at Marshall | ESPN+
6 p.m. | Texas Southern at Cal | ESPN+/ACC Extra
6 p.m. | Florida A&M at FAU | ESPN+
6 p.m. | AIC at Central Connecticut State | NEC Front Row
6 p.m. | Warner at Stetson | TBD TV
6 p.m. | Davidson at Elon | FloFootball
6 p.m. | Rhode Island at Stony Brook | FloFootball
6 p.m. | Elizabeth City State at Hampton | FloFootball
6 p.m. | Holy Cross at New Hampshire | FloFootball
6 p.m. | Monmouth at Fordham | ESPN+
6 p.m. | Richmond at Wofford | ESPN+
6 p.m. | Houston Christian at Eastern Kentucky | ESPN+
6 p.m. | Colgate at Villanova | FloFootball
6 p.m. | Maine at William & Mary | FloFootball
6 p.m. | Saint Anselm at Merrimack | ESPN+
6 p.m. | Virginia State at Norfolk State | ESPN+
7 p.m. | Tulane at South Alabama | ESPN+
7 p.m. | Bethune-Cookman at Miami (Fla.) | ESPN+/ACC Extra
7 p.m. | Western Kentucky at Toledo | ESPN+
7 p.m. | North Carolina at Charlotte | ESPN+
7 p.m. | Memphis at Georgia State | ESPN+
7 p.m. | Army at Kansas State | ESPN
7 p.m. | Houston at Rice | ESPN+
7 p.m. | South Carolina State at South Carolina | ESPN+/SEC Network+
7 p.m. | North Carolina A&T at UCF | ESPN+
7 p.m. | LIU at Eastern Michigan | ESPN+
7 p.m. | West Georgia at Nicholls | ESPN+
7 p.m. | Adrian College at Valparaiso | TBD TV
7 p.m. | Portland State at North Dakota | ESPN+
7 p.m. | Alcorn State at Alabama A&M | HBCU GO
7 p.m. | Mississippi Valley State at Tarleton State | ESPN+
7 p.m. | Morehead State at Illinois State | ESPN+
7 p.m. | North Alabama at Southeast Missouri State | ESPN+
7 p.m. | Arkansas-Pine Bluff at Central Arkansas | ESPN+
7 p.m. | South Dakota at Lamar | ESPN+
7 p.m. | Alabama State at Southern | ESPN+
7 p.m. | UTRGV at Prairie View A&M | SWAC TV
7 p.m. | Northern Colorado at Colorado State | Altitude Sports
7 p.m. | Towson at Morgan State | ESPN+
7 p.m. | Southeastern Louisiana at Murray State | ESPN+
7:30 p.m. | Arizona State at Mississippi State | ESPN2
7:30 p.m. | Vanderbilt at Virginia Tech | ACC Network
7:30 p.m. | Michigan at Oklahoma | ABC
The Sooners are laying almost a touchdown at home in this contest. Michigan steps into its first true test with freshman quarterback Bryce Underwood guiding the offense. The Wolverines will try to lean on a physical line and the running tandem of Jordan Marshall and Justice Haynes to control tempo in Norman. Defensively, Michigan’s secondary will be tested against a wide-open attack. Last week, Underwood looked comfortable in his debut win, showing the poise Michigan will need in a hostile environment.
Oklahoma answers with transfer quarterback John Mateer, whose quick release and mobility fuel the Sooners’ up-tempo style. The home crowd will provide a boost, and Oklahoma’s defense will be eager to pressure the freshman QB. The Sooners rolled in their opener, giving them momentum heading into this primetime clash.
7:30 p.m. | Charleston Southern at Coastal Carolina | ESPN+
7:30 p.m. | Ball State at Auburn | ESPNU
7:30 p.m. | Boston College at Michigan State | NBC/Peacock
7:30 p.m. | Akron at Nebraska | Big Ten Network
7:30 p.m. | Southern Illinois at Purdue | Big Ten Network
7:30 p.m. | Georgia Southern at USC | FS1
7:30 p.m. | Louisiana Tech at LSU | ESPN+/SEC Network+
7:45 p.m. | UL Monroe at Alabama | SEC Network
8 p.m. | McNeese at Louisiana | ESPN+
8 p.m. | UCLA at UNLV | CBSSN
8 p.m. | South Dakota State at Montana State | ESPN+
8p.m. | Stephen F. Austin at Abilene Christian | ESPN+
8 p.m. | Central Washington at Montana | ESPN+
9 p.m. | UT Martin at UTEP | ESPN+
9 p.m. | Tulsa at New Mexico State | ESPN+
9 p.m. | Southern Utah at San Diego | TBD TV
10 p.m. | Weber State at Arizona | ESPN+
10:15 p.m. | San Diego State at Washington State | The CW Network
10:15 p.m. | Stanford at BYU | ESPN
11 p.m. | UC Davis at Washington | Big Ten Network
11:59 p.m. | Sam Houston at Hawaii | Spectrum Sports
2025-2026 College Football Schedule
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