College Football Week 6 Best Bets - Football Lines
Week 6 college football features a trio of marquee matchups that will significantly impact conference races and College Football Playoff positioning, headlined by Miami's trip to Florida State on Saturday night in a rivalry clash that has lost some luster after the Seminoles' shocking double-overtime loss to Virginia. The undefeated Hurricanes (4-0) travel to Doak Campbell Stadium riding high after their dominant 26-7 victory over Florida, establishing themselves as the ACC's clear championship frontrunner while Florida State (3-1) must regroup from their stunning 46-38 setback that ended their own unbeaten start. Mario Cristobal's squad has emerged as a legitimate national title contender behind an explosive offense and opportunistic defense, while Mike Norvell's Seminoles face the urgent task of proving their Virginia loss was an aberration rather than a sign of deeper issues that plagued them throughout 2024.
The weekend's other premier attractions showcase critical conference battles with massive postseason implications, as undefeated Texas (4-0) visits Florida (3-1) in a clash between SEC heavyweights that could determine the league's hierarchy. Steve Sarkisian's Longhorns have methodically dismantled their opposition through four weeks, including a statement 55-0 demolition of Sam Houston, while Billy Napier's Gators are seeking to bounce back from their lopsided loss to Miami and prove they belong among the conference elite. The stakes are equally high when surging Vanderbilt (5-0) travels to Alabama (3-1) in a rematch of last year's historic upset that sent shockwaves through college football. Clark Lea's Commodores have continued their remarkable transformation with an impressive 55-35 victory over Utah State, while Kalen DeBoer's Crimson Tide are coming off their statement 24-21 upset of Georgia that silenced critics and demonstrated their championship credentials.
These three games represent pivotal moments in their respective conference races, with each carrying significant weight for the 12-team College Football Playoff picture as we approach the midpoint of the regular season. Miami's opportunity to essentially eliminate Florida State from ACC title contention comes against a wounded opponent desperate to salvage their championship aspirations in the hostile environment of Tallahassee. Texas-Florida presents a classic SEC showdown where the winner gains crucial momentum in what promises to be a brutally competitive conference race, while Vanderbilt's chance to prove their breakthrough 2024 campaign was sustainable faces the ultimate test against an Alabama program determined to avoid another humiliating loss to the Commodores. The outcomes of these contests will reshape the national landscape and provide clarity on which programs possess the fortitude to navigate the pressure-packed final two months of the season.
Week 6 delivers the type of high-stakes college football that defines championship seasons, with prime television coverage across all major networks ensuring fans won't miss any of the action. From afternoon clashes to primetime spectacles, the weekend promises the kind of memorable moments that college football fans live for, with multiple games carrying both immediate and long-term consequences for the playoff chase.
College Football Betting Lines
Ready to Bet on College Football?
Bet 2025 College Football odds at BookMaker—spreads, totals, player props, and championship futures all season long.
* Trusted by sharp bettors for over 30 years
* Early odds, fast payouts, and Bitcoin betting
* Live betting and mobile-optimized sportsbook
* Don’t just watch the action — bet on it!
* Sign Up Now and lock in your College Football picks today!
2025-2026 College Football Week 6 Schedule
Thursday, October 2, 2025
9 p.m. | Sam Houston at New Mexico State | CBSSN
Friday, October 3, 2025
7 p.m. | Western Kentucky at Delaware | CBSSN
7 p.m. | Charlotte at South Florida | ESPN2
10 p.m. | New Mexico at San Jose State | FS1
10:30 p.m. | West Virginia at BYU | ESPN
10:30 p.m. | Colorado State at San Diego State | CBSSN
Saturday, October 4, 2025
12 p.m. | Kentucky at Georgia | ABC
12 p.m. | Iowa State at Cincinnati | ESPN2
12 p.m. | Wisconsin at Michigan | FOX
12 p.m. | Illinois at Purdue | Big Ten Network
12 p.m. | Boston College at Pitt | ACC Network
12 p.m. | Clemson at North Carolina | ESPN
12 p.m. | Kansas State at Baylor | ESPN+
12 p.m. | Air Force at Navy | CBS/Paramount+
12 p.m. | Army at UAB | ESPNU
12 p.m. | Ohio at Ball State | CBSSN
1 p.m. | Wake Forest at Virginia Tech | The CW Network
1 p.m. | UTSA at Temple | ESPN+
2 p.m. | Campbell at NC State | ESPN+/ACC Extra
2 p.m. | Oklahoma State at Arizona | TNT/truTV/HBO Max
2:30 p.m. | Western Michigan at UMass | ESPN+
3:30 p.m. | Penn State at UCLA | CBS
3:30 p.m. | Texas at Florida
Two of college football's most scrutinized quarterbacks collide in Gainesville as Texas (4-0) visits Florida (3-1) in a critical SEC showdown that could define both programs' championship aspirations with the Longhorns listed as road favorites in NCAA football odds. Arch Manning's Texas debut against Ohio State exposed the growing pains of inheriting unprecedented expectations, as the sophomore completed just 17 of 30 passes for 170 yards in a 14-7 loss before rebounding with a dominant 309-yard, five-touchdown performance against Sam Houston. Manning has shown flashes of the dual-threat ability that makes him the betting favorite for the Heisman Trophy, but his inconsistency on intermediate throws and tendency to hold the ball too long have raised questions about whether he can handle SEC pressure against a Florida defense that has allowed only 38 points through three games. Meanwhile, DJ Lagway's season has been a tale of extremes, from his record-setting 456-yard debut as a true freshman to his crushing five-interception performance against LSU that highlighted fundamental issues with reading coverage and decision-making under pressure.
The matchup presents fascinating contrasts between two highly-recruited signal-callers carrying the weight of massive expectations and NIL deals worth millions of dollars. Lagway enters having completed 83 of 123 passes for 690 yards with five touchdowns and six interceptions, still showing the explosive downfield arm that made him a five-star recruit but struggling with consistency in Billy Napier's system. Steve Sarkisian's Texas offense will test a Florida defense that has been opportunistic but untested against elite competition, while the Longhorns' rebuilt offensive line faces its first true road test in the hostile environment of Ben Hill Griffin Stadium. Both quarterbacks desperately need signature performances to silence critics and validate their programs' championship hopes, as Texas seeks to prove their early season struggles were aberrations while Florida must demonstrate that Lagway's development can carry them through a brutal SEC schedule that offers little margin for error.
3:30 p.m. | Vanderbilt at Alabama
The Crimson Tide are double-digit home favorites in college football odds against the Commodores. It is the most anticipated revenge game in college football, as Vanderbilt (5-0) travels to Tuscaloosa to face Alabama (3-1) in a rematch of last year's seismic 40-35 upset that sent shockwaves through the sport and derailed the Crimson Tide's championship hopes. Diego Pavia brings the confidence of his greatest triumph into hostile territory, having outdueled Heisman candidate Jalen Milroe last year at Vanderbilt with a masterful 16-of-20 performance for 252 yards and two touchdowns that snapped Alabama's 23-game winning streak against the Commodores dating back to 1984. The charismatic quarterback has continued his stellar play in 2025, leading Clark Lea's program to their first 5-0 start in decades while establishing Vanderbilt as a legitimate SEC contender rather than the conference doormat that Nick Saban once famously dismissed as the only easy road game in the league. Pavia's dual-threat ability and clutch gene will face the ultimate test in Bryant-Denny Stadium, where an Alabama crowd desperate to exorcise last year's demons will create a hostile environment unlike anything the Commodores have experienced this season.
Alabama enters the contest with new leadership under center, as Ty Simpson has taken over the starting quarterback role following Jalen Milroe's departure to the NFL, bringing a different dynamic to Kalen DeBoer's offense that is still searching for its identity in Year 2 of the post-Nick Saban era. The Crimson Tide's 24-21 victory over Georgia demonstrated their resilience and championship potential, but the shadow of last year's Vanderbilt debacle looms large as a reminder of how quickly momentum can shift in college football's unforgiving landscape. DeBoer has installed new offensive coordinator Ryan Grubb's system while retaining explosive playmakers like Ryan Williams, but this Alabama team lacks the veteran leadership and championship swagger that defined previous Crimson Tide squads. The stakes couldn't be higher for both programs, as Vanderbilt seeks to prove their breakthrough 2024 campaign was sustainable while Alabama desperately needs to avoid another humiliating loss that would cast serious doubt on their ability to compete for SEC and national championships under their new coaching regime.
3:30 p.m. | Boise State at Notre Dame | NBC/Peacock
3:30 p.m. | Washington at Maryland | Big Ten Network
3:30 p.m. | UL Monroe at Northwestern | Big Ten Network
3:30 p.m. | Oregon State at Appalachian State | ESPN+
3:30 p.m. | Virginia at Louisville
3:30 p.m. | Syracuse at SMU
3:30 p.m. | Florida International at UConn | CBSSN
3:30 p.m. | James Madison at Georgia State | ESPN+
3:30 p.m. | Central Michigan at Akron | ESPN+
3:30 p.m. | Eastern Michigan at Buffalo | ESPN+
3:30 p.m. | Miami (Ohio) at Northern Illinois | ESPN+
4 p.m. | Kent State at Oklahoma | SEC Network
4 p.m. | Michigan State at Nebraska | FS1
4 p.m. | Texas State at Arkansas State | ESPNU
6 p.m. | Coastal Carolina at Old Dominion | ESPN+
7 p.m. | Texas Tech at Houston | ESPN
7 p.m. | UNLV at Wyoming | CBSSN
7 p.m. | South Alabama at Troy | ESPN+
7 p.m. | Florida Atlantic at Rice | ESPN+
7:30 p.m. | Minnesota at Ohio State | NBC/Peacock
7:30 p.m. | Miami (Fla.) at Florida State | ABC
The most anticipated rivalry clash in the ACC takes center stage as Miami (4-0) travels to Tallahassee to face Florida State (3-1) in a primetime showdown that will reshape the conference championship race and restore luster to one of college football's most storied rivalries. The Hurricanes are listed as small road favorites in NCAA football odds. Carson Beck has transformed Miami's championship aspirations since transferring from Georgia, bringing veteran leadership and elite arm talent to Mario Cristobal's program while establishing himself as a legitimate Heisman Trophy candidate through four dominant performances. The former Bulldog signal-caller has showcased the poise and accuracy that made him one of the nation's premier quarterbacks, leading an explosive Hurricanes offense that has averaged over 35 points per game while navigating the early season schedule with surgical precision. Beck's familiarity with high-pressure moments and big-game environments will be crucial as Miami seeks to maintain their perfect record in the hostile confines of Doak Campbell Stadium, where the Seminoles desperately need a signature victory to validate their resurgence under Mike Norvell.
Florida State enters the contest with renewed optimism behind Tommy Castellanos, whose dual-threat ability has provided the spark that Mike Norvell's offense desperately needed after years of quarterback instability. The Seminoles have shown flashes of their championship potential through three games, but inconsistency on both sides of the ball has prevented them from taking the definitive step forward that would cement their status as ACC contenders. Norvell's program faces a defining moment, as a victory over undefeated Miami would not only announce their arrival as legitimate championship threats but also serve as validation for the recruiting momentum and program building that has taken place since their disappointing 2024 campaign. The atmosphere in Tallahassee will be electric as both fan bases understand the magnitude of this clash, with the winner positioning themselves as the clear favorite to represent the ACC in the College Football Playoff while the loser faces an uphill battle to remain relevant in the expanded postseason picture.
7:30 p.m. | Mississippi State at Texas A&M | SEC Network
7:30 p.m. | Colorado at TCU | FOX
7:30 p.m. | Kansas at UCF | ESPN2
8 p.m. | Tulsa at Memphis | ESPNU
10:30 p.m. | Duke at Cal | ESPN
10:30 p.m. | Nevada at Fresno State | CBSSN
2025-2026 College Football Schedule
Did You Know?
At BookMaker, we go beyond just providing top-notch sports betting options! Take advantage of these exclusive features and rewards:
BookMaker ATM Card for seamless transactions: Easily access your funds with the BookMaker ATM card, providing instant access to your winnings and secure transactions wherever you go.
Loyalty Levels & BetPoints Programs for additional rewards: Earn BetPoints as you bet, and unlock exciting perks at higher loyalty levels. The more you play, the more you earn!
Seasonal and Reload Bonuses to maximize your earnings: Stay ahead with seasonal promotions and reload bonuses, boosting your bankroll throughout the year.
Early Cashout Option for added flexibility: Cash out your bet early and lock in profits or limit losses—putting you in control of your wagers.
Free Crypto Payouts for fast and secure withdrawals: Enjoy fast, secure withdrawals with zero fees when you choose crypto payouts.
Open Play Option for unique parlay betting: Get creative with your parlays using the Open Play option, offering more ways to win.
Casino Promotions & Contests for extra fun and wins: Join in on exclusive casino promotions and contests, adding excitement to your betting experience.
8% Cash Back on all your horse racing bets: Place horse racing bets and get 8% cash back on your losses, making it easier to bounce back.
Explore all these benefits and more at BookMaker!
Betting Rules & Policies
Free Play Rules
- Free plays cannot be used on proposition bets.
- Free Plays do not earn any BetPoints™
- Bets made using Free Plays do not count towards completing any rollovers. (Free Plays are always subject to a rollover of their own. You must complete the required rollover prior to making a withdrawal).
- The maximum payout for any Free Play is $5,000.
- Free Plays that are left unused for 180 days will be removed from your account.
ROLLOVER
- Did you know that on all deposits made at BookMaker, there is a rollover requirement: an amount of betting action you must fulfill before you are eligible to make a withdrawal.
- Did you know that rollovers are calculated by multiplying the amount initially credited to your account a certain number of times? Yes! If you deposit without claiming any bonus, the rollover will always be 1x (one-time) your deposit amount. If you do claim a deposit bonus, the rollover will be higher and is based on the deposit plus bonus amount.
Wager disputes (claims)
If you disagree with any aspect of a wager you’ve placed, you are welcome to log an official dispute (commonly known as a “claim”). Claims must be reported no later than 15 (fifteen) calendar days following the settlement of the wager.
If following an initial review of the case there remains any doubt regarding the wager type, line, market, amount, or any other detail, the claim will be escalated to the BookMaker management team. All decisions made by them are final.
Wager Cash Out - How it works
With the Cash Out feature you can choose to eliminate a wager that's already been placed, and receive back either a portion, or your full stake amount.
Cash Out is selectively available on certain events, fixtures, and markets.
In order to see if a wager is eligible to be cashed out, simply navigate to your Bet Slip and check the 'My Open Bets' tab. If eligible, the Cash Out button will be displayed.
It’s also important to note that Cash Out is not contributing to any bonus or promotion including Bet Point accumulation and Rollover for releasing bonus cash.
