Last week was sobering evidence that the Detroit Lions and Baltimore Ravens are not to be kicked when they are down. Both teams took out their anger from Week 1 losses into powerful payouts.
On Monday Night, ESPN gets a matchup that could be a Super Bowl preview. The Baltimore Ravens will host the Detroit Lions in a game that features two of the best teams, quarterbacks, and coaches on the board.
Jared Goff of Detroit and Lamar Jackson of Baltimore will keep the chains moving. Dan Campbell of Detroit and John Harbaugh of Baltimore are in the elite coaching class.
These two teams nearly clashed on Super Sunday the past two years. Betting action is already high for this one.
Monday Night Football is a traditionally strong draw for betting interest at Bookmaker. When the matchup between top Super Bowl contenders is on the board, that interest is exemplified.
Explore the latest Week 3 NFL betting lines and predictions for Monday Night Football.
NFL Betting Lines
Detroit Lions at Baltimore Ravens Odds at Bookmaker
M&T Bank Stadium is the venue on Monday, September 22, 2025, for the Monday Night Football matchup of the host Baltimore Ravens and the Detroit Lions. Kickoff time is at 8:15 p.m. ET with television coverage on ABC and ESPN.
The Detroit Lions opened as a +6.5-point road underdog against the Baltimore Ravens, who were listed as -6.5-point home favorites.
The Ravens and Lions opened with a total of 51.5.
On the moneyline, the Ravens opened as -258 home favorites with the Lions a +210 road dog.
Please check back regularly here at Bookmaker for the latest pro and college football odds.
Detroit Lions
Last week, the Detroit Lions won 52-21 over the Chicago Bears as 6.5-point home favorites. The game went over the total of 46.5. As a result, the Lions are 1-1 straight up, 1-1 against the spread, and 1-1 over the total.
Detroit ranks 14th for total offense and 4th for points allowed. By contrast, Detroit ranks 9th for total defense and 21st for points allowed.
Jared Goff threw five touchdown passes — three to Amon Ra St. Brown — and the host Detroit Lions rolled past the Chicago Bears on Sunday. In sum, Goff hit 23 of 28 passes and racked up 334 passing yards for a nearly perfect 156.0 quarterback rating.
Baltimore Ravens
Last game, the Baltimore Ravens won 41-17 against the Cleveland Browns as 13.5-point home favorites. The game went over the total of 46.5. Baltimore is 1-1 straight up, 1-1 against the spread, and 2-0 over the total.
Overall, the Ravens rank 18th for total offense and 1st for scoring offense. Baltimore ranks 24th for total defense and 26th for points allowed.
Lamar Jackson passed for 225 yards and four touchdowns to help spoil Joe Flacco’s homecoming. The Baltimore Ravens notched a blowout and payout over the visiting Cleveland Browns in an AFC North battle on Sunday afternoon.
Roquan Smith returned a fumble 63 yards for a touchdown and had 15 tackles, including three for losses, for the Ravens.
Nate Wiggins returned an interception 60 yards to set up a Ravens’ touchdown.
Finally, Jake Hummel blocked a punt to set up a field goal.
Lions at Ravens Betting Trends
Detroit is one of the best values on the board in away games. For example, the Lions covered the spread in 16 of their most recent 20 road tilts. Detroit went over the total in only two of its most recent six games.
Meanwhile, the Ravens lost only two of their most recent eight home games vs. the spread. Five of their last seven home games went over the total.
In the series between the Lions and Ravens, Baltimore has won five of the most recent seven meetings. Additionally, Detroit and Baltimore exceeded their total in six of their last nine games.
Specifically in Baltimore, the Lions failed to bring home the bacon in their last five games against the Ravens. The Ravens and Lions went over the total in four of their last five games at Baltimore.
Lions at Ravens Best Bets
To conclude, the Ravens have demonstrated a home-field advantage against the Lions. Also, Baltimore delivers solid value at home.
Main Pick: Baltimore Ravens
Over/Under Pick: Over the Total
Player Prop Picks: Lamar Jackson Over the Total Yards Total
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