Two of the biggest surprise teams of the 2025 NFL season will clash on Monday Night.
The Carolina Panthers entered the season as one of the least respected teams in pro sports.
But as the drive to the 2025 NFL Playoffs begins, the Panthers are in the thick of the race.
Although Bryce Young has remained inconsistent at quarterback, the Panthers' defense has saved the season.
Meanwhile, the San Francisco 49ers are in the race with backup quarterback Mac Jones rebooting his career in place of the injured Brock Purdy.
Purdy returned last week and flashed a winning performance.
The 49ers are a legacy brand that will draw plenty of betting traffic for a Monday night setting.
Get the latest NFL Week 12 news, check out the current betting lines for the games, and don’t miss Monday Night Football action, all with the best odds at BookMaker!
Carolina Panthers at San Francisco 49ers Odds at Bookmake
Levi’s Stadium in Santa Clara, CA, is the venue for the matchup between the Carolina Panthers and the San Francisco 49ers on Monday, November 24, 2025. Kickoff time is at 8:15 p.m. ET with television coverage on ESPN.
Oddsmakers opened with San Francisco as a 7-point favorite and Carolina as a 7-point dog.
San Francisco is a -335 moneyline favorite against Carolina, a +270 moneyline dog.
San Francisco and Carolina opened with a total of 47.5.
Despite its improved play this year, the Panthers remain a tough sell to gamblers.
Carolina will need to do more to convince gamblers that they can be trusted.
Bargain hunters know that Carolina will pay a higher price because of its branding.
Meanwhile, the casual sector will largely gravitate toward the 49ers' iconic brand at home.
Carolina Panthers
Last game, the Carolina Panthers won 30-27 in overtime against the Atlanta Falcons as 3.5-point road dogs. The game went over the total of 41.5.
Carolina is 6-5 straight up, 7-4 against the spread, and 6-5 over/under the total.
Carolina ranks 23rd for total offense, 28th for passing, 10th for rushing, 28th for scoring, and 27th for fewest turnovers committed.
Carolina ranks 14th in total defense, 14th vs. the pass, 17th vs. the rush, 13th in fewest points allowed, and 14th in takeaways.
Late on, Carolina has covered five out of its most recent seven games. Carolina went under the total in two of its last three matchups.
Carolina is in 2nd place in the NFC South Division.
San Francisco 49ers
Last game, the San Francisco 49ers won 41-22 against the Arizona Cardinals as 3.5-point road favorites. The game went over the total of 48.5.
San Francisco is 7-4 straight up, 6-5 against the spread, and 7-3-1 over/under the total.
San Francisco ranks 11th for total offense, 4th for passing, 27th for rushing, 16th for scoring, and 29th for fewest turnovers committed.
San Francisco ranks 22nd for total defense, 28th vs. the pass, 10th vs. the rush, 15th for fewest points allowed, and 30th for takeaways.
Late on, San Francisco has covered three out of its most recent five games. San Francisco went over the total in three of its last three matchups.
San Francisco is in 3rd place in the NFC West Division.
Panthers at 49ers Betting Trends
Carolina has covered five of its most recent eight road games.
The Panthers went under the total in three of their most recent five home games.
San Francisco got the money in four of its last six home games.
The 49ers went over the total in 13 of their most recent 20 home games.
Carolina has dominated the payout window against San Francisco.
The Panthers covered 14 of their last 18 games against the 49ers.
The 49ers and Panthers went over the total in 15 of their last 20 meetings.
In San Francisco, the Panthers covered the spread in three of their last four visits.
Two of the last three games between the Panthers and 49ers at San Francisco went under the total.
Panthers at 49ers Best Bets
As mentioned earlier, the Panthers have been highly profitable against the 49ers.
Carolina has plenty of defense and enough to stay within the number, at the very least.
San Francisco is overpriced, given its status as one of the most popular casual brands.
Main Pick: Carolina Panthers
Over/Under Pick: Under the Total
Player Prop Picks: Bryce Young Over the Total Yards Total
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