For gamblers and commentators who warned that the Kansas City Chiefs' dynasty was nearing an end, they are looking prescient after two weeks of play.
Following a playoff season in his first year as head coach, Brian Daboll has had nothing but problems with the Giants. New York was touted as a team on the rise three years ago, but instead has become a pariah.
Meanwhile, there are increasing doubts that the Kansas City Chiefs' dynasty is nearing its end. The Chiefs stumbled out of the gate with a loss to the Chargers. Next came a Super Bowl revenge home game against the Eagles in Kansas City. The Chiefs did not have enough to exact revenge.
The Kansas City Chiefs always generate betting interest at Bookmaker. The New York Giants remain a brand with a large following as well.
Explore the latest Week 3 NFL betting lines and predictions for Sunday Night Football.
NFL Betting Lines
Kansas City Chiefs at New York Giants Odds at Bookmaker
MetLife Stadium is the venue for the marquee brand matchup of the Kansas City Chiefs and the host New York Giants on Sunday, September 21, 2025. Kickoff time is 8:20 p.m. ET with television coverage on NBC.
The Kansas City Chiefs opened as a 5.5-point road favorite against the New York Giants, who were listed as 5.5-point home dogs.
The Chiefs and Giants opened with a total of 44.5.
On the moneyline, the Chiefs opened as a -250 road favorite with the Giants as a +205 home dog.
Please check back regularly here at Bookmaker for the latest pro and college football odds.
Kansas City Chiefs
Last week, the Kansas City Chiefs lost 20-17 against the Philadelphia Eagles as 1-point home dogs. The game went under the total of 47.5. As a result, Kansas City is 0-2 straight up, 0-2 against the spread, and 1-1 over the total.
Overall, Kansas City ranks 24th for total offense and 22nd for scoring offense. By contrast, the Chiefs rank 12th for total defense and 20th for points allowed.
Patrick Mahomes completed 16 of 29 passes for 187 yards, one touchdown, and one interception for the Kansas City Chiefs. Mahomes also rushed for a team-high 66 yards and a touchdown. Although the Chiefs outgained the Eagles 294-216, they fell short.
New York Giants
Last week, the New York Giants lost 40-37 as 5.5 road dogs. The game went over the total of 44.5. Now, New York is 0-2 straight up, 1-1 against the spread, and 1-1 over the total.
Overall, New York ranks 15th for total offense and 18th for scoring offense. New York ranks 25th for total defense and 28th for scoring defense.
Russell Wilson went 30-of-41 passing for 450 yards and three touchdowns for New York.
Additionally, Malik Nabers caught nine passes for 167 yards and two touchdowns, including a go-ahead score after Pickens’ TD grab.
Brandon Aubrey hit the game-winning field goal as time expired in overtime to give the Dallas Cowboys a dramatic win over the New York Giants.
Chiefs at Giants Betting Trends
The Chiefs have experienced recent struggles on the road, with only two wins in their last eight road matchups. Kansas City went under the total in three of its last five away matchups.
In like manner, the Giants have struggled in recent home games with only three payouts in their last nine matchups. The Giants went under the total in 12 of their last 17 home games.
In the series between the Chiefs and Giants, New York covered the spread in nine of the most recent ten meetings. The series went over the total in only three of the last 11 meetings.
Specifically at MetLife Stadium, the Giants won their last five games against the Chiefs. The last three games between the Giants and Chiefs in New York went under the total.
Chiefs at Giants Best Bets
In this situation, the Chiefs will get a more favorable price on the road against a weaker team. The Giants can’t yet be trusted.
Main Pick: Kansas City Chiefs
Over/Under Pick: Under the Total
Player Prop Picks: Patrick Mahomes Over the Passing Yards Total
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