The Buffalo Bills and Miami Dolphins are heading in opposite directions. These two AFC East rivals go back. Way back.
On Thursday, Prime Video will kick off NFL Week 3 with an AFC East rivalry matchup that dates back to 1966, when the American Football League was established.
Additionally, this game will provide a stark contrast in team culture. The Miami Dolphins have a poor betting value reputation for being soft.
By contrast, the Buffalo Bills are known as resilient and tough as nails. Buffalo will host Miami on Thursday night in an important game that could determine the future path for the 2025 season.
Following its Week 1 thriller over the Baltimore Ravens, Buffalo routed the New York Jets.
Thursday Night Football is a consistent draw for betting interest at Bookmaker. The Buffalo Bills and Miami Dolphins are brands that will draw further wagering handle.
Explore the latest Week 3 NFL betting lines and predictions for Thursday Night Football.
NFL Betting Lines
Miami Dolphins at Buffalo Bills Odds at Bookmaker
Highmark Stadium in Buffalo, NY, is the venue for the AFC East rivalry showdown between the Buffalo Bills and Miami Dolphins on Thursday, September 18, 2025. Kickoff time is at 8:15 p.m. ET with television coverage on Prime Video.
The Miami Dolphins opened as a +12.5-point road dog while the Buffalo Bills are -12.5-point home favorites.
The Dolphins and Bills opened with a total of 49.5.
On the moneyline, the Dolphins opened as +550 road dogs with the Bills as -800 favorites.
Please check back regularly here at Bookmaker for the latest pro and college football odds.
Miami Dolphins
Last week, the Miami Dolphins lost 33-27 to the New England Patriots as 2.5-point home favorites. The game went over the total of 42.5. Miami is 0-2 straight up, 0-2 against the spread, and 1-1 over the total.
Overall, Miami ranks 5th in total offense but 32nd in scoring and 29th in fewest turnovers committed. The Dolphins rank 31st in total defense, 30th in fewest points allowed, and 27th in takeaways.
Miami quarterback Tua Tagovailoa completed 26 of 32 passes for 315 yards and two touchdowns, with one interception.
Tyreek Hill energized the offense with 109 yards on six catches.
De’Von Achane led the Dolphins with 30 rushing yards and also contributed 92 receiving yards and a touchdown.
Buffalo Bills
Last game, the Buffalo Bills won 30-10 against the New York Jets as 6-point road favorites. The game went under the total of 47.5. Buffalo is 2-0 straight up, 2-0 against the spread, 1-1 over the total.
Buffalo ranks 8th for total offense and 2nd for scoring offense. In comparison, the Bills rank 6th for total defense, 22nd for points allowed, and 29th for takeaways.
James Cook rushed for 132 yards with two touchdowns as Matt Prater booted three field goals, and the Buffalo Bills won over the New York Jets.
Overall, the Bills dominated, holding a 403-154 edge in total yardage and a 25-11 margin in first downs over the Jets.
Dolphins at Bills Betting Trends
Miami has been a weak betting value on the road. To show, the Dolphins have covered the spread in only six of their last 17 games in that role. Miami went under the total in 12 of its most recent 18 road games.
In comparison, Buffalo got the money in eight of its most recent ten home games. The Bills went over the total in 11 of their last 14 home games.
In this series, Buffalo is 5-4-1 against the spread vs. Miami with only one straight-up loss in that span. Four of the most recent six games between the Bills and Dolphins went over the total.
Specifically at Buffalo, the Dolphins are 3-1-1 against the spread in their most recent five visits. Additionally, the Bills and Dolphins exceeded the total in nine of their last 10 games at Buffalo.
Dolphins at Bills Best Bets
In this situation, Miami makes for a contrarian pick. Too much public money is on Buffalo. Too many people are writing off the Dolphins.
Main Pick: Miami Dolphins
Over/Under Pick: Over the Total
Player Prop Picks: Tua Tagovailoa Over the Passing Yardage Total
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