Now in his fourth season as head coach of the Oklahoma Sooners, Brent Venables is in danger of continuing a worrisome college football betting odds trend.
Venables has started each campaign off impressively, only to have his team fade down the stretch.
Following a 5-0 start, Oklahoma’s loss to Texas revealed a team that was overrated at #5 in the country. This week brings a dangerous home game for OU.
Head coach Lane Kiffin and his Ole Miss Rebels will come calling on Saturday. Accordingly, Kiffin leads one of the best Rebel teams ever.
Ole Miss and Oklahoma are two of the biggest brands on the 2025 college football board.
In an SEC showdown with playoff implications, there will be intense interest and significant betting activity surrounding this game.
Explore the latest College Football betting lines, odds, and predictions for Week 9.
College Football Betting Lines
Mississippi Rebels at Oklahoma Sooners Odds at Bookmaker
Gaylord Family OK Memorial Stadium is the venue for the matchup between the Ole Miss Rebels and the Oklahoma Sooners on Saturday, October 24, 2025. Kickoff time is at Noon ET with television coverage on ABC.
Oddsmakers opened with Oklahoma as a 3.5-point favorite and Ole Miss as a 3.5-point dog.
Oklahoma is a -182 moneyline favorite with Ole Miss as a +150 moneyline dog.
Ole Miss and Oklahoma opened with a total of 51.5.
Mississippi Rebels
Last game, the Ole Miss Rebels lost 26-14 against the Georgia Bulldogs as 7.5-point road dogs. The game went over the total of 57.
As a result, Ole Miss is 6-1 straight up, 4-3 against the spread, and 4-3 over/under the total.
Ole Miss ranks 10th for total offense, 12th for passing, 42nd for rushing, 17th for scoring, and 80th for fewest turnovers committed.
In comparison, Ole Miss ranks 62nd for total defense, 37th vs. the pass, 98th vs. rush, 54th for fewest points allowed, and 121st for takeaways.
Oklahoma Sooners
Last game, the Oklahoma Sooners won 26-7 against the South Carolina Gamecocks as 4.5-point road favorites. The game went under the total of 43.
Now, Oklahoma is 6-1 straight up, 3-3-1 against the spread, and 0-7 over/under the total.
Overall, Oklahoma ranks 71st for total offense, 41st for passing, 111th for rushing, 67th for scoring, and 94th for fewest turnovers committed.
OU ranks 1st for total defense, 1st vs. the pass, 6th vs. rush, 2nd for fewest points allowed, and 132nd for takeaways.
Mississippi at Oklahoma Betting Trends
On the road, Ole Miss failed to cover only seven of its last 17 road games.
The Rebels went under the total in eight of their most recent 11 away tilts.
Meanwhile, Oklahoma got the money in 12 of its most recent 18 games at home.
The Sooners went under the total in six of their last eight home games.
Specifically, the road team has covered both previous meetings in this series.
The games went 1-1 over the total.
Last year, Ole Miss beat Oklahoma 26-14 as 19-point home favorites.
The game went under the total of 50. It was the first meeting in 25 years between the teams.
Mississippi at Oklahoma Best Bets
Oklahoma is one of the great historic brands in college football. Hence, the Causal sector flocks to the betting window when the Sooners play. But much of the Sooners' public cache is based on a past that no longer exists.
Still, the Sooners will draw plenty of casual support as the Blue Blood hosts.
Previously, Ole Miss lacked the respect that it is now earning.
Lane Kiffin has changed the brand and dynamics of the Rebels.
Ole Miss is drawing more public betting support than in any time in its history.
Ole Miss brings plenty of offense against an Oklahoma team that relies on defense.
In this spot, the Rebels will offer more value as the quality road team against a name brand.
Main Pick: Ole Miss Rebels
Over/Under Pick: Under the Total
Player Prop Picks: John Mateer Under the Total Yards Total
Make your bets now at BookMaker and get fast Bitcoin payouts, the best odds available anywhere, and don’t forget about live betting at BookMaker Sportsbook!
