Two of the best and most successful franchises in the NFL will clash on Sunday in the NFC Wild Card Playoffs.
The Philadelphia Eagles have made the playoffs in eight of their last nine seasons, with three Super Bowl appearances and two Lombardi Trophies. Last year, Philadelphia decimated the Kansas City Chiefs in one of the most dominant Super Bowl performances of all time.
Since 2019, the San Francisco 49ers have made the playoffs five times, won two NFC championships, and suffered bitter Super Bowl losses to the Kansas City Chiefs.
Two of the brightest coaches and quarterbacks will also clash. Kyle Shanahan of San Francisco and Nick Sirianni of Philadelphia are two of the best head coaches in the NFL with impeccable resumes. Quarterbacks Brock Purdy of the 49ers and Jalen Hurts of the Eagles continue to confound their critics.
A Sunday afternoon Fox playoff game with two power brands will ignite massive viewership and betting traffic.
Get the latest NFL Wild Card Round news, check out the current betting lines for the games, and don’t miss the football action, all with the best odds at BookMaker!
San Francisco 49ers at Philadelphia Eagles Odds at Bookmaker
Lincoln Financial Field in Philadelphia, PA, will host the San Francisco 49ers vs. Philadelphia Eagles matchup on Sunday, January 11, 2026. Kickoff time is at 4:30 p.m. ET with television coverage on FOX.
Oddsmakers opened with Philadelphia as a 4.5-point favorite and San Francisco as a 4.5-point dog. Philadelphia is a -220 moneyline favorite against San Francisco, which is a +184 moneyline dog. Philadelphia and San Francisco opened with an over/under total of 44.5.
San Francisco will draw plenty of sharps and Wise Guys as the experienced, power playoff team, getting the enhanced price on the road.
The Casual sector will flock to the defending Super Bowl champions with the supposed home field advantage.
San Francisco 49ers
Last game, the San Francisco 49ers lost 13-3 against the Seattle Seahawks as 2.5-point home dogs. The game went under the total of 48. As a result, San Francisco is 12-5 straight up, 11-6 against the spread, and 10-6 over/under the total.
San Francisco ranks 18th for total offense, 9th for passing, 26th for rushing, 10th for scoring, and 17th for fewest turnovers committed.
San Francisco ranks 14th for total defense, 17th vs. the pass, 5th vs. the rush, 13th for fewest points allowed, and 30th for takeaways.
San Francisco has covered six out of its most recent seven games. The 49ers went over the total in three of their last four matchups.
Philadelphia Eagles
Last game, the Philadelphia Eagles lost 24-17 against the Washington Commanders as 3.5-point home favorites. The game went over the total of 39. As a result, Philadelphia is 11-6 straight up, 10-7 against the spread, and 7-10 over/under the total.
Philadelphia ranks 25th for total offense, 23rd for passing, 20th for rushing, 19th for scoring, and 4th for fewest turnovers committed.
Philadelphia ranks 13th for total defense, 8th vs. the pass, 21st vs. the rush, 5th for fewest points allowed, and 15th for takeaways.
Philadelphia has covered three out of its most recent four games. The Eagles went over the total in two of their last three matchups.
49ers at Eagles Betting Trends
The 49ers covered the spread in six of their last seven games. The 49ers went over the total in six of their last nine matchups. The 49ers are 6-1 straight up in their last seven games. The 49ers covered the spread in four of their last five away games.
The Eagles went under the total in seven of their last nine games. The Eagles went under the total in 14 of their last 18 January games.
Philadelphia got the cash in nine of its last 12 games with the 49ers. The Eagles are 8-4 straight up against San Francisco. San Francisco saw the payout window in eight of its last 12 away games against the Eagles. The Niners and Eagles went under the total in five of their last six meetings.
49ers at Eagles Best Bets
The Eagles have not been as sharp as they were last year. The 49ers are in strong form and have performed well in Philadelphia. In an even matchup, the power dog 49ers make the most sense.
Main Pick: San Francisco 49ers
Over/Under Pick: Under the Total
Player Prop Picks: Jalen Hurts Under the Total Yards Total
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